Results 131 to 140 of about 120,872 (251)

Role of SUMO in RNF4-mediated Promyelocytic Leukemia Protein (PML) Degradation

Journal of Biological Chemistry, 2009
Promyelocytic leukemia protein (PML) is a tumor suppressor acting as the organizer of subnuclear structures called PML nuclear bodies (NBs). Both covalent modification of PML by the small ubiquitin-like modifier (SUMO) and non-covalent binding of SUMO to
Y. Percherancier, D. Germain-Desprez, F. Galisson, X. Mascle, L. Dianoux, Patricia Estephan, M. Chelbi-alix, M. Aubry   +7 more
semanticscholar   +1 more source

Estudo da associação de genes e proteínas de resistência a múltiplos fármacos (abcb1/ABCB1, abcc1/ABCC1 e lrp/LRP) com marcadores moleculares em pacientes portadores de leucemias agudas [PDF]

, 2013
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2013.Menos de 45% dos portadores de leucemias agudas (LAs) sobrevivem cinco anos após o diagnóstico. O insucesso
Moraes, Ana Carolina Rabello de
core  

USP22 regulates APL differentiation via PML-RARα stabilization and IFN repression

Cell Death Discovery
Ubiquitin-specific peptidase 22 (USP22) is a deubiquitinating enzyme (DUB) that underlies tumorigenicity, proliferation, cell death and differentiation through deubiquitination of histone and non-histone targets.
Lisa Kowald, Jens Roedig, Rebekka Karlowitz, Kristina Wagner, Sonja Smith, Thomas Juretschke, Petra Beli, Stefan Müller, Sjoerd J. L. van Wijk   +8 more
doaj   +1 more source

New strategies to direct therapeutic targeting of PML to treat cancers

Frontiers in Oncology, 2013
The tumor suppressor function of the promyelocytic leukemia (PML) protein was first identified as a result of its dysregulation in acute promyelocytic leukemia (APL), however, its importance is now emerging far beyond hematological neoplasms, to an ...
Kamil eWolyniec, Kamil eWolyniec, Dennis Anthony Carney, Dennis Anthony Carney, Dennis Anthony Carney, Sue eHaupt, Sue eHaupt, Ygal eHaupt, Ygal eHaupt, Ygal eHaupt, Ygal eHaupt   +10 more
doaj   +1 more source

ATO (Arsenic Trioxide) Effects on Promyelocytic Leukemia Nuclear Bodies Reveals Antiviral Intervention Capacity

Advanced Science, 2020
Human adenoviruses (HAdV) are associated with clinical symptoms such as gastroenteritis, keratoconjunctivitis, pneumonia, hepatitis, and encephalitis.
Samuel Hofmann, Julia Mai, Sawinee Masser, Peter Groitl, Alexander Herrmann, Thomas Sternsdorf, Ruth Brack‐Werner, Sabrina Schreiner   +7 more
doaj   +1 more source

Human Papillomavirus: Update in Bridging Basic Science to Clinical and Public Health Innovations

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Human papillomavirus (HPV), a non‐enveloped, double‐strand DNA viral pathogen, is intricately linked with the onset of various cancers, including cervical cancer and head and neck cancers. The present paper delves into HPV's ancient recognition and significant milestones such as the discovery of its role in oncogenesis and the development of ...
Fatemeh Beygnejad, Narges Eslami, Kaveh Gharaei Nejad, Atefeh Zamani Kermanshahi, Hossein Bannazadeh Baghi   +4 more
wiley   +1 more source

Porcine promyelocytic leukemia protein isoforms suppress Japanese encephalitis virus replication in PK15 cells. [PDF]

Virol J, 2023
Chen Z, Liu H, Zhu J, Duan X, Wang H, Li X, Zhou X, Zhao A, Yang S.   +8 more
europepmc   +1 more source

Post‐Translational Modifications of Key Proteins in Hematologic Malignancies: Carcinogenic Mechanisms, Biomarker Potential, and New Therapeutic Strategies

iLABMED, Volume 4, Issue 2, Page 91-107, June 2026.
This article reviews the pivotal role of post‐translational modifications of proteins in the development and progression of hematologic malignancies, and explores their clinical translation potential as novel biomarkers and therapeutic targets. ABSTRACT Post‐translational modifications (PTMs) of proteins have emerged as critical regulators in the ...
Yuxuan Han, Chaowei Zhang, Weiyi Yao, Qing Hong, Xinyu Tang, Yanan Zhu, Na Chen   +6 more
wiley   +1 more source

The acute promyelocytic leukemia-specific PML-RAR alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells

, 1993
Acute promyelocytic leukemia is a clonal expansion of hematopoietic precursors blocked at the promyelocytic stage. The differentiation block can be reversed by retinoic acid, which induces blast maturation both in vitro and in vivo.
Myriam Alcalay, F. Grignani, U. Testa, Pier Francesco Ferrucci, Cesare Peschle, G. Talamo, Francesco Grignani, Fausto Grignani, P. F. Ferrucci, Pier Giuseppe Pelicci, M. Fagioli, P. G. Pelicci, M. Alcalay, A. Mencarelli, I. Nicoletti, Giampaolo Talamo, Marta Fagioli, Ugo Testa, Ildo Nicoletti, C. Peschle, Amedea Mencarelli   +20 more
core   +1 more source

The role of PML proteins in adenovirus type 5 infection and the type I interferon response [PDF]

Promyelocytic leukaemia (PML) proteins consist of a collection of related isoforms that are the nucleating components of sub-nuclear structures termed PML nuclear bodies (PML NBs). Numerous functions are attributed to PML and PML NBs, including a role
Wright, Jordan
core