Results 151 to 160 of about 120,872 (251)

Identification and functional characterization of the novel MAR-binding protein, SATB2 [PDF]

, 2004
The regulation of gene expression is governed in large part by transcription factors that bind to enhancers and promoters. The functions of transcription factors involve both the modulation of chromatin accessibility via the recruitment of histone ...
Dobreva, Gergana
core  

Resistance to Arsenic Therapy in Acute Promyelocytic Leukemia

, 2014
Although resistance to arsenic trioxide in patients with acute promyelocytic leukemia is very rare, mutations in PML at the site of arsenic binding appears to be the main mechanism of resistance.To the Editor: Acute promyelocytic leukemia (APL) is a ...
Zhu, Hong-Hu, Huang, Xiao-Jun, Qin, Ya-Zhen   +2 more
core   +1 more source

Promyelocytic Leukemia Protein Potently Restricts Human Cytomegalovirus Infection in Endothelial Cells. [PDF]

Int J Mol Sci, 2022
Seitz S, Heusel AT, Stamminger T, Scherer M.   +3 more
europepmc   +1 more source

Multiplexed Transcriptomics for Screening Drug Combinations and Defining the Mechanism of Action of HCC Therapeutics at Single‐Cell Resolution

Cell Proliferation, Volume 59, Issue 6, June 2026.
We designed a framework for screening clinical drug combinations with anti‐hepatocellular carcinoma (HCC) activity, comprising four parts: primary screening, single‐cell screening, functional validation, and mechanism research. High‐throughput single‐cell screening identifies HY (HHT and YM155) as a potent anti‐HCC drug combination, validated by in ...
Mengmeng Jiang, Haide Chen, Guoxia Wen, Yuqing Mei, Wenzhao Zhou, Bin Xu, Tingyue Zhang, Guangyan Li, Junqing Wu, Xiaoping Han, Xudong Fu, Guoji Guo, Jingjing Wang   +12 more
wiley   +1 more source

Retinoic Acid and Arsenic Trioxide sensitize Acute Promyelocytic Leukemia cells to ER stress

, 2017
Promyelocytic leukemia (APL) is characterized by the chromosomal translocation t(15:17) that results in the expression of the chimeric protein PML-RARα. The fusion of PML, a tumor suppressor that is the major component of the PML-nuclear bodies, with the
FAZI, Francesco, Divona, Mariadomenica, MASCIARELLI, SILVIA, Ottone, Tiziana, Lo Coco Francesco,, Noguera, Nelida, CAPUANO, ERNESTINA, DE PANFILIS, SIMONE   +7 more
core  

Metaphase and Interphase Cytogenetics with Alu-PCR-amplified Yeast Artificial Chromosome Clones Containing the BCR Gene and the Protooncogenes c-raf-1, c-fms, and c-erbB-21 [PDF]

, 1992
A human yeast artificial chromosome (YAC) library was screened by polymerase chain reaction with oligonucleotide primers defined for DNA sequences of the BCR gene and the protooncogenes c-raf-1, c-fms, and c-erB-2.
Olson, Maynard V., Riethman, Harold C., Green, Eric D., Becher, Reinhard, Taniwaki, Masafumi, Michael R. Speicher, Speicher, Michael R., Cremer, Thomas, Christoph Lengauer, Eric D. Green, Konecki, David, Maynard V. Olson, David Konecki, Reinhard Becher, Harold C. Riethman, Lengauer, Christoph, Masafumi Taniwaki, Thomas Cremer   +17 more
core  

Common Hematologic Emergencies—Acute Promyelocytic Leukemia and Microangiopathic Hemolytic Anemias—A Pivotal Role of Clinical Laboratory

International Journal of Laboratory Hematology, Volume 48, Issue 3, Page 521-530, June 2026.
ABSTRACT Hematologic emergencies are urgent health conditions which result in significant mortality and morbidity unless timely therapeutic measures are taken. Therapeutic success depends on their timely and accurate recognition by hematology laboratory services.
Ganna Shestakova, Nicolas Ulrich Edgar, Anton V. Rets   +2 more
wiley   +1 more source

Post-translational modifications of PML: consequence and implications

Frontiers in Oncology, 2013
The tumor suppressor promyelocytic leukemia protein (PML) predominantly resides in a structurally distinct sub-nuclear domain called PML nuclear bodies (NBs).
Xiwen eCheng, Hung-Ying eKao
doaj   +1 more source

Proto-oncogene c-jun expression is induced by AML1-ETO in a JNK dependent manner:possible role in the pathogenesis of acute myeloid leukemia [PDF]

, 2003
Overexpression of proto-oncogene c-jun and constitutive activation of the Jun NH2-terminal kinase (JNK) signaling pathway have been implicated in the leukemic transformation process.
Elsaesser, Annika
core  

3C protease of enterovirus 71 cleaves promyelocytic leukemia protein and impairs PML-NBs production. [PDF]

Virol J, 2021
Li Z, Wu Y, Li H, Li W, Tan J, Qiao W.
europepmc   +1 more source