Results 161 to 170 of about 120,872 (251)

Reciprocal t(9;22) ABL/BCR fusion proteins: leukemogenic potential and effects on B cell commitment

, 2009
Background: t(9;22) is a balanced translocation, and the chromosome 22 breakpoints (Philadelphia chromosome – Ph+) determine formation of different fusion genes that are associated with either Ph+ acute lymphatic leukemia (Ph+ ALL) or chronic myeloid ...
Xiaomin Zheng, Malcolm A S Moore, Martin Ruthardt, Ruthardt, Martin, Oancea, Claudia, Claudia Oancea, Malcolm A. S. Moore, Reinhard Henschler, Henschler, Reinhard, Moore, Malcolm A. S., Zheng, Xiaomin   +10 more
core   +1 more source

Manipulation of Promyelocytic Leukemia Protein Nuclear Bodies by Marek's Disease Virus Encoded US3 Protein Kinase. [PDF]

Microorganisms, 2021
Liao Y, Lupiani B, Reddy SM.
europepmc   +1 more source

Emerging role for microRNAs in acute promyelocytic leukemia

, 2007
Hematopoiesis is highly controlled by lineage-specific transcription factors that, by interacting with specific DNA sequences, directly activate or repress specific gene expression.
FAZI, Francesco, NERVI, Clara, BOZZONI, Irene, ROSA, ALESSANDRO, FATICA, Alessandro   +4 more
core   +1 more source

Fast pH‐Driven Solubilization Method of Realgar (As4S4) to Reduce the Toxicity of Arsenic [As(III)] for Medicinal Purposes

Advanced Science
Acute promyelocytic leukemia (APL) accounts for 5–15% of acute myeloid leukemia cases. It is typically characterized by the (15;17) chromosomal translocation, producing the pathogenic retinoic acid receptor (RAR) alpha/promyelocytic leukemia (PML) fusion
Bojana Lucic, Douglas Santana Franciscato, Helton Pereira Nogueira, Lara Gallucci, Alceu Totti Silveira Junior, Asmaa Mohamed Ismail, Millie Robinson, Teresa Dallinger, Claudia Gutfleisch, Jochen Kurz, Maytê Toledo, Jessica Dias da Silva Ferraz, Mohammad Tarek, Danilo Dias, Ricardo Sobhie Diaz, Mahmoud ElHefnawi, Mattia Forcato, Hugo P Monteiro, Marina Lusic, Iart Luca Shytaj, Andrea Savarino   +20 more
doaj   +1 more source

Dual Functions of Histone-Lysine N-Methyltransferase Setdb1 Protein at Promyelocytic Leukemia-Nuclear Body (PML-NB)

, 2011
Setdb1/Eset is a histone H3 lysine 9 (H3K9)-specific methyltransferase that associates with various transcription factors to regulate gene expression via chromatin remodeling.
Jung Sun Park, Sun Hwa Cho, Sunwha Cho, Yong-Kook Kang   +3 more
core   +1 more source

Forkhead O Transcription Factor 4 Restricts HBV Covalently Closed Circular DNA Transcription and HBV Replication through Genetic Downregulation of Hepatocyte Nuclear Factor 4 Alpha and Epigenetic Suppression of Covalently Closed Circular DNA via Interacting with Promyelocytic Leukemia Protein. [PDF]

J Virol, 2022
Li Y, He M, Gong R, Wang Z, Lu L, Peng S, Duan Z, Feng Y, Liu Y, Gao B.   +9 more
europepmc   +1 more source

The promyelocytic leukemia protein PML has a pro-apoptotic activity mediated through its RING domain

, 1997
The promyelocytic leukemia protein PML is known to form nuclear multiprotein complexes which are compromised in several pathogenic conditions including acute promyelocytic leukemia.
Maria S Salvato, Salvato, Maria S, CampbellDwyer, Elizabeth J, Borden, Katherine L.B, Katherine L.B Borden, Elizabeth J CampbellDwyer   +5 more
core   +1 more source

Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice

, 1997
Acute promyelocytic leukemia (APL) is associated with reciprocal chromosomal translocations involving the retinoic acid receptor alpha (RARalpha) locus on chromosome 17.
P. G. Pelicci, G. Cattoretti, V. Soares, D. Peruzzi, L. Z. He, C. Tribioli, R. Rivi, P. P. Pandolfi   +7 more
core   +1 more source

C-terminal motifs in promyelocytic leukemia protein isoforms critically regulate PML nuclear body formation

Journal of Cell Science, 2017
Chuang Li, Q. Peng, X. Wan, Haili Sun, Jun Tang   +4 more
semanticscholar   +1 more source

Disease-specific epigenetic deregulation of enhancers, transposons, and polycomb targets in acute promyelocytic leukemia

Genome Medicine
Background Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML), characterized by a fusion between the PML and RARA genes and by a block in the myeloid maturation at the promyelocytic stage.
Xiangfu Zhong, Lina Cordeddu, Angelica Gamboa-Cedeno, Sofia Bengtzén, Karl Ekwall, Andreas Lennartsson, Sören Lehmann   +6 more
doaj   +1 more source