Results 171 to 180 of about 43,079 (212)

Activation of a promyelocytic leukemia–tumor protein 53 axis underlies acute promyelocytic leukemia cure

Nature Medicine, 2014
Acute promyelocytic leukemia (APL) is driven by the promyelocytic leukemia (PML)-retinoic acid receptor-α (PML-RARA) fusion protein, which interferes with nuclear receptor signaling and PML nuclear body (NB) assembly. APL is the only malignancy definitively cured by targeted therapies: retinoic acid (RA) and/or arsenic trioxide, which both trigger PML ...
Julien Ablain   +5 more
openaire   +4 more sources

Promyelocytic leukemia protein: an atherosclerosis suppressor protein?

Clinical Science, 2021
Abstract As many as 70% of cells in atherosclerotic plaque are vascular smooth muscle cell (VSMC) in origin, and pathways and proteins which regulate VSMC migration, proliferation, and phenotype modulation represent novel targets for rational drug design to reduce atherosclerotic vascular disease.
Cali B, Corbett   +2 more
openaire   +2 more sources

ImageStream promyelocytic leukemia protein immunolocalization: In search of promyelocytic leukemia cells

Cytometry Part A, 2012
AbstractAcute promyelocytic leukemia (APL) is a hematological emergency in which a rapid diagnosis is essential for early administration of appropriate therapy, including all‐trans retinoic acid before the onset of fatal coagulopathy. Currently, the following methodologies are widely used for rapid initial diagnosis of APL: 1) identification of ...
Mirabelli P.   +10 more
openaire   +3 more sources

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