Results 181 to 190 of about 43,079 (212)

Acute promyelocytic leukemia with a PLZF-RARα fusion protein

Seminars in Hematology, 2001
In most cases of acute promyelocytic leukemia (APL), a fusion of the promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha) genes occurs, resulting in the expression of a PML-RARalpha chimeric protein. In approximately 1% of the cases of APL, variant chromosomal aberrations may be found fusing RARa with other genes.
Jansen, J.H., Lowenberg, B.
openaire   +4 more sources

Loss of promyelocytic leukemia protein in human gastric cancers

Cancer Letters, 2007
To clarify the clinical implications of promyelocytic leukemia (PML) expression in gastric carcinomas, the expression of PML was analyzed in large series of gastric carcinoma by immunohistochemistry, western blotting and reverse transcription-PCR. PML protein expression was reduced or abolished in gastric carcinomas (31.7 and 10.6%, respectively) by ...
Hee Eun, Lee, Chang Do, Jee, Min A, Kim, Hye Seung, Lee, You Mie, Lee, Byung Lan, Lee, Woo Ho, Kim   +6 more
openaire   +2 more sources

Role of Promyelocytic Leukemia Protein in Host Antiviral Defense

Journal of Interferon & Cytokine Research, 2011
Several pathways have been implicated in the establishment of antiviral state in response to interferon (IFN), one of which implicates the promyelocytic leukemia (PML) protein. The PML gene has been discovered 20 years ago and has led to new insights into oncogenesis, apoptosis, cell senescence, and antiviral defense.
Marie-Claude, Geoffroy, Mounira K, Chelbi-Alix   +1 more
openaire   +2 more sources

New Powerful Insulin-Like Protein from Human Promyelocytic Leukemia Cells

Endocrinology, 1984
Potent insulin-like activity was found in the conditioned medium of human promyelocytic leukemia (HL-60) cells. The conditioned medium of HL-60 cells at high density stimulated [3H]glucose incorporation into lipids in rat adipocytes in a time- and dose-dependent manner.
T, Yamanouchi, Y, Akanuma, T, Tsushima, K, Shizume, H, Mizoguchi, F, Takaku   +5 more
openaire   +2 more sources

Promyelocytic leukemia protein (PML) and stem cells: from cancer to pluripotency

The International Journal of Developmental Biology, 2022
The promyelocytic leukemia protein (PML) is the core organizer of cognate nuclear bodies (PML-NBs). Through physical interaction or modification of diverse protein clients, PML-NBs regulate a multitude of - often antithetical- biological processes such as antiviral and stress response, inhibition of cell proliferation and autophagy, and promotion of ...
Amalia P, Vogiatzoglou, Fabien, Moretto, Maria, Makkou, Joseph, Papamatheakis, Androniki, Kretsovali   +4 more
openaire   +2 more sources

Functions and dys-functions of promyelocytic leukemia protein PML

Rendiconti Lincei. Scienze Fisiche e Naturali, 2018
The promyelocytic leukemia protein PML has been previously recognized as a critical and essential regulator of a broad number of cellular functions. At nuclear level PML forms the PML-nuclear bodies, where it can sequester and influence the post-translational modification of a wide number of proteins, ultimately affecting their regulative role in DNA ...
Previati, Maurizio, Missiroli, Sonia, Perrone, Mariasole, Caroccia, Natascia, Paliotto, Federico, Milani, Daniela, Giorgi, Carlotta   +6 more
openaire   +2 more sources

Promyelocytic Leukemia Protein, a Protein at the Crossroad of Oxidative Stress and Metabolism

Antioxidants & Redox Signaling, 2017
Cellular metabolic activity impacts the production of reactive oxygen species (ROS), both positively through mitochondrial oxidative processes and negatively by promoting the production of reducing agents (including NADPH and reduced glutathione). A defined metabolic state in cancer cells is critical for cell growth and long-term self-renewal, and such
Tessier, Sarah, Martin-Martin, Natalia, de Thé, Hugues, Carracedo, Arkaitz, Lallemand-Breitenbach, Valérie   +4 more
openaire   +3 more sources

Acute promyelocytic leukemia fusion proteins: up to new tricks

Blood, 2003
In this issue, Kawasaki and colleagues (page [3668][1]) demonstrate that the nuclear-matrix–associated protein, promyelocytic leukemia protein (PML), binds to and inhibits Stat3 transcriptional activity. The region of Stat3 bound by PML includes its DNA binding domain.
openaire   +1 more source

Promyelocytic leukemia protein specifically augments the activation of NFAT (136.11)

The Journal of Immunology, 2009
Abstract Promyelocytic leukemia (PML) protein is a tumor suppressor with complicated action mechanisms not yet fully understood. Nuclear factor of activated T cells (NFAT) is an important factor for T cell functions. In this study, we found that PML specifically enhanced the transcription activation of NFAT.
Yu-Hsun Lo, Chia-Chen Wu, Hsiu-Ming Shih, Ming-Zong Lai   +3 more
openaire   +1 more source

Expression of granule protein mRNAs in acute promyelocytic leukemia.

Hematologic pathology, 1994
The granule proteins are among the most abundant and characteristic proteins of myeloid cells. They are essential for the antimicrobial activity of these cells and they provide important markers for the differentiation stage of the myeloid series and for the diagnosis of myeloid leukemias.
R K, Hirata, S T, Chen, S C, Weil
openaire   +1 more source