Results 111 to 120 of about 43,079 (212)

The Tribble with APL: a new road to therapy [PDF]

, 2017
The t(15;17) translocation generates a PML-RARα fusion protein causative for acute promyelocytic leukemia (APL). Li et al. now identify the pseudokinase stress protein TRIB3 as an important factor in APL disease progression and therapy resistance ...
Carmody, Ruaidhri, Keeshan, Karen
core   +1 more source

Phosphate Transporters Mediate the Uptake of Monothioarsenate

Plant, Cell &Environment, Volume 49, Issue 5, Page 2628-2638, May 2026.
ABSTRACT Arsenic (As) is one of the most problematic environmental toxins. Exposure to As, predominantly via drinking water and the intake of food, represents a major human health threat. Various species of As exist in the environment, among them organic and inorganic thioarsenates.
Sebastian Haider, Sylvia Hafner, Britta Planer‐Friedrich, Stephan Clemens   +3 more
wiley   +1 more source

PML Nuclear bodies: the cancer connection and beyond

Nucleus
Promyelocytic leukemia (PML) nuclear bodies, membrane-less organelles in the nucleus, play a crucial role in cellular homeostasis. These dynamic structures result from the assembly of scaffolding PML proteins and various partners.
Majdouline Abou-Ghali, Valérie Lallemand-Breitenbach   +1 more
doaj   +1 more source

Preventing hereditary cancers caused by opportunistic carcinogens [PDF]

, 2011
Objectives Previous studies reported inherited BRCA1/2 deficits appear to cause cancer by impairing normal protective responses to some carcinogens.
Bernard Friedenson
core   +2 more sources

PU.1 controls the expression of long noncoding RNA HOTAIRM1 during granulocytic differentiation [PDF]

, 2016
Background Long noncoding RNA HOX antisense intergenic RNA myeloid 1 (HOTAIRM1) has been characterized as a critical factor in all-trans retinoic acid (ATRA)-induced differentiation of acute promyelocytic leukemia (APL) cells.
Kankan Wang, Ming Zhao, Shuyong Wei, Xiaoling Wang, Yizhen Li   +4 more
core   +2 more sources

New strategies to direct therapeutic targeting of PML to treat cancers

Frontiers in Oncology, 2013
The tumor suppressor function of the promyelocytic leukemia (PML) protein was first identified as a result of its dysregulation in acute promyelocytic leukemia (APL), however, its importance is now emerging far beyond hematological neoplasms, to an ...
Kamil eWolyniec, Kamil eWolyniec, Dennis Anthony Carney, Dennis Anthony Carney, Dennis Anthony Carney, Sue eHaupt, Sue eHaupt, Ygal eHaupt, Ygal eHaupt, Ygal eHaupt, Ygal eHaupt   +10 more
doaj   +1 more source

ATO (Arsenic Trioxide) Effects on Promyelocytic Leukemia Nuclear Bodies Reveals Antiviral Intervention Capacity

Advanced Science, 2020
Human adenoviruses (HAdV) are associated with clinical symptoms such as gastroenteritis, keratoconjunctivitis, pneumonia, hepatitis, and encephalitis.
Samuel Hofmann, Julia Mai, Sawinee Masser, Peter Groitl, Alexander Herrmann, Thomas Sternsdorf, Ruth Brack‐Werner, Sabrina Schreiner   +7 more
doaj   +1 more source

Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia [PDF]

, 2010
Gain of chromosome 8 is the most common chromosomal gain in human acute myeloid leukemia (AML). It has been hypothesized that gain of the MYC protooncogene is of central importance in trisomy 8, but the experimental data to support this are limited and ...
Jones, L., Wei, G., Sevcikova, S., Phan, V., Jain, S., Shieh, A., Wong, J. C., Li, M., Dubansky, J., Maunakea, M. L., Ochoa, R., Zhu, G., Tennant, T. R., Shannon, K. M., Lowe, S. W., Le Beau, M. M., Kogan, S. C.   +16 more
core   +1 more source

USP22 regulates APL differentiation via PML-RARα stabilization and IFN repression

Cell Death Discovery
Ubiquitin-specific peptidase 22 (USP22) is a deubiquitinating enzyme (DUB) that underlies tumorigenicity, proliferation, cell death and differentiation through deubiquitination of histone and non-histone targets.
Lisa Kowald, Jens Roedig, Rebekka Karlowitz, Kristina Wagner, Sonja Smith, Thomas Juretschke, Petra Beli, Stefan Müller, Sjoerd J. L. van Wijk   +8 more
doaj   +1 more source

Porcine promyelocytic leukemia protein isoforms suppress Japanese encephalitis virus replication in PK15 cells. [PDF]

Virol J, 2023
Chen Z, Liu H, Zhu J, Duan X, Wang H, Li X, Zhou X, Zhao A, Yang S.   +8 more
europepmc   +1 more source