Results 111 to 120 of about 120,872 (251)

A bayesian network model of proteins' association with promyelocytic leukemia (PML) nuclear bodies

, 2010
The modularity that nuclear organization brings has the potential to explain the function of aggregates of proteins and RNA. Promyelocytic leukemia nuclear bodies are implicated in important regulatory processes.
Boden, Mikael, Bailey, Timothy L., Bailey, Timothy, Burrage, Kevin, Dellaire, Graham   +4 more
core   +1 more source

Human surfactant protein D alters oxidative stress and HMGA1 expression to induce p53 apoptotic pathway in eosinophil leukemic cell line [PDF]

, 2013
This article is made available through the Brunel Open Access Publishing Fund. Copyright: © 2013 Mahajan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use ...
Pandit Hrishikesh, Uday Kishore (504246), Ravi Sirdeshmukh, P. Usha Sarma (504245), Curam S Sundaram, Lakshna Mahajan (504239), Madan, T, Ajit K Yadav, Madan Taruna, Poonam Gautam, Ajit K. Yadav (504242), Curam S. Sundaram (504244), Yadav Ajit K., Ravi Sirdeshmukh (131378), Himangi Warke, P. Usha Sarma, Surolia Avadhesha, Warke Himangi, Lakshna Mahajan, Hrishikesh Pandit, Pandit, H, Sundaram, CS, Himangi Warke (504243), Sarma, PU, Poonam Gautam (131332), Sundaram Curam S., Sirdeshmukh Ravi, Sarma P. Usha, Surolia, A, Curam S. Sundaram, Avadhesha Surolia (78297), Mahajan, L, Kishore Uday, Yadav, AK, Sirdeshmukh, R, Warke, H, Taruna Madan, Kishore, U, Taruna Madan (504241), P Usha Sarma, Gautam, P, Mahajan Lakshna, Gautam Poonam, Hrishikesh Pandit (504240), Ajit K. Yadav, Avadhesha Surolia, Uday Kishore   +46 more
core   +1 more source

Mutation in the Unrearranged PML Allele Confers Resistance to Arsenic Trioxide in Acute Promyelocytic Leukemia

Research
Arsenic trioxide (ATO) is able to selectively target and degrade the disease-causing PML::RARα (P/R) oncoprotein in acute promyelocytic leukemia (APL) for curing the disease.
Pei-Han Yu, Chen-Ying Zhu, Yuan-Yuan Kang, Hua Naranmandura, Chang Yang   +4 more
doaj   +1 more source

Mitogen-activated Protein Kinase Extracellular Signal-regulated Kinase 2 Phosphorylates and Promotes Pin1 Protein-dependent Promyelocytic Leukemia Protein Turnover*

Journal of Biological Chemistry, 2011
Background: The degradation of promyelocytic leukemia (PML) protein is regulated by phosphorylation-dependent manner. Results: The inhibition or knockdown of ERK2 increase PML expression level and decrease the interaction between PML and Pin1. Conclusion:
J. Lim, Yu Liu, Erin Reineke, H. Kao
semanticscholar   +1 more source

The human promyelocytic leukemia protein is a tumor suppressor for murine skin carcinogenesis [PDF]

Molecular Carcinogenesis, 2008
AbstractExpression of the PMLRARα fusion dominant‐negative oncogene in the epidermis of transgenic mice resulted in spontaneous skin tumors attributed to changes in both the PML and RAR pathways [Hansen et al., Cancer Res 2003; 63:5257–5265]. To determine the contribution of PML to skin tumor susceptibility, transgenic mice were generated on an FVB/N ...
Victoria M, Virador, Rafael E, Flores-Obando, Adam, Berry, Rinal, Patel, Julia, Zakhari, Yu-Chien, Lo, Kathryn, Strain, Joanna, Anders, Christophe, Cataisson, Laura A, Hansen, Stuart H, Yuspa   +10 more
openaire   +2 more sources

The role of promyelocytic leukemia protein in genome maintenance [PDF]

, 2022
Promyelocytic leukemia protein (PML) is a key component for a formation of the PML nuclear bodies (PML−NBs) in which PML forms a shell surrounding an inner core of this dynamic multiprotein komplex.
Kindlová, Martina
core  

Qingdainone, a novel bioactive compound in Realgar‒Indigo naturalis, induced apoptosis and differentiation in ATRA‐sensitive and ‐resistant acute promyelocytic leukaemia cells

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
1. Network pharmacology identified Qingdainone as a key bioactive compound in RIF. 2. Molecular docking revealed strong binding affinities of Qingdainone to targets such as CCND1, CDK1, CDK4, CASP3 and CASP7. 3. Qingdainone interfered proliferation and apoptosis, and promoted differentiation, of ATRA‐sensitive and ‐resistant APL cells, such that ...
Pengcheng Xu, Yang Ou, Xin Tan, Lili Ji, Yanxia Zhan, Pu Chen, Hao Chen, Yunfeng Cheng   +7 more
wiley   +1 more source

Promyelocytic leukemia protein in retinoic acid-induced chromatin remodeling of Oct4 gene promoter

Stem Cells, 2011
Promyelocytic leukemia (Pml) protein is required for Oct4 gene expression and the maintenance of its open chromatin conformation in stem cells. In proliferating stem cells, Pml‐nuclear body, along with transcription factors TR2, steroidogenic factor 1 ...
Ya-Shan Chuang, Wei-Hong Huang, Sung Wook Park, Shawna D. Persaud, C. Hung, P. Ho, Li-Na Wei   +6 more
semanticscholar   +1 more source

Resistance to Virus Infection Conferred by the Interferon-Induced Promyelocytic Leukemia Protein [PDF]

Journal of Virology, 1998
ABSTRACTThe interferon (IFN)-induced promyelocytic leukemia (PML) protein is specifically associated with nuclear bodies (NBs) whose functions are yet unknown. Two of the NB-associated proteins, PML and Sp100, are induced by IFN. Here we show that overexpression of PML and not Sp100 induces resistance to infections by vesicular stomatitis virus (VSV ...
M K, Chelbi-Alix, F, Quignon, L, Pelicano, M H, Koken, H, de Thé   +4 more
openaire   +2 more sources

NAT10‐mediated N4‐acetylcytidine modification drives RNA splicing of PML to alleviate adipose‐derived stem cell senescence and promote diabetic wound healing

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
N‐acetyltransferase 10 (NAT10) catalyses N4‐acetylcytidine (ac4C) modification of PML pre‐mRNA, shifting splicing from the senescence‐promoting PML‐FL to the senescence‐inhibiting PML‐S isoform via SRSF1. This rejuvenates adipose‐derived stem cells (ADSCs) by reducing senescence markers and senescence‐associated secretory phenotype (SASP), thereby ...
Wuhan Wei, Chanyuan Jiang, Dong Zhu, Xuefeng Han, Xuan Ma, Xinyu Jia, Jiaqi Ling, Rui Zhang, Facheng Li, Ningbei Yin   +9 more
wiley   +1 more source