Results 11 to 20 of about 120,872 (251)

ImageStream promyelocytic leukemia protein immunolocalization: In search of promyelocytic leukemia cells

Cytometry Part A: the Journal of the International Society for Analytical Cytology, 2012
AbstractAcute promyelocytic leukemia (APL) is a hematological emergency in which a rapid diagnosis is essential for early administration of appropriate therapy, including all‐trans retinoic acid before the onset of fatal coagulopathy. Currently, the following methodologies are widely used for rapid initial diagnosis of APL: 1) identification of ...
Peppino Mirabelli, Giulia Scalia, Thaddeus C George   +2 more
exaly   +5 more sources

Targeting the acute promyelocytic leukemia-associated fusion proteins PML/RARα and PLZF/RARα with interfering peptides.

PLoS ONE, 2012
In acute promyelocytic leukemia (APL), hematopoietic differentiation is blocked and immature blasts accumulate in the bone marrow and blood. APL is associated with chromosomal aberrations, including t(15;17) and t(11;17).
Sabine Beez, Philipp Demmer, Elena Puccetti   +2 more
doaj   +2 more sources

Cellulitis with Leukocytopenia as an Initial Sign of Acute Promyelocytic Leukemia

Case Reports in Dermatology, 2012
Patients with hematologic malignancies are immunosuppressive and may develop cutaneous or invasive infections as a primary sign of immune suppression.
Sachiko Sakamoto, Naoki Oiso, Masakatsu Emoto, Shusuke Uchida, Ayaka Hirao, Yoichi Tatsumi, Itaru Matsumura, Akira Kawada   +7 more
doaj   +2 more sources

Promyelocytic Leukemia Protein (PML) and Stem Cells: from cancer to pluripotency.

The International Journal of Developmental Biology, 2021
The promyelocytic leukemia protein (PML) is the core organizer of the cognate nuclear bodies (PML-NBs). Through physical interaction or modification of diverse protein clients, PML-NBs regulate a multitude of - often antithetical- biological processes ...
A. Vogiatzoglou, Fabien Moretto, Maria Makkou, J. Papamatheakis, A. Kretsovali   +4 more
semanticscholar   +3 more sources

Epstein - Barr virus latent membrane protein 1 suppresses reporter activity through modulation of promyelocytic leukemia protein-nuclear bodies [PDF]

Virology Journal, 2011
The Epstein-Barr virus (EBV) encoded Latent Membrane Protein 1 (LMP1) has been shown to increase the expression of promyelocytic leukemia protein (PML) and the immunofluorescent intensity of promyelocytic leukemia nuclear bodies (PML NBs).
Flemington Erik K, Shan Bin, Chadwick Reid W, Block Gregory J, Sides Mark D, Lasky Joseph A   +5 more
doaj   +2 more sources

Promyelocytic Leukemia Protein Interacts with the Apoptosis-associated Speck-like Protein to Limit Inflammasome Activation*

Journal of Biological Chemistry, 2014
Background: ASC is the common adaptor of caspase-1 activation in several inflammasomes. Results: A novel interaction between PML and ASC is identified. PML-deficient macrophages display enhanced levels of IL-1β secretion and higher levels of ASC in the ...
J. Dowling, Christine E. Becker, Nollaig M. Bourke, S. Corr, D. Connolly, Susan R. Quinn, P. Pandolfi, A. Mansell, L. O’Neill   +8 more
semanticscholar   +3 more sources

Three-Way Translocation t(12;15;17) (p13;q24;q21) Found in Acute Promyelocytic Leukemia with Basophilic Differentiation

Hematology Reports
Acute promyelocytic leukemia is a rare form of acute myeloid leukemia in which immature promyelocytes abnormally proliferate in the bone marrow. In most cases, the disease is characterised by the translocation t(15;17) (q24;q21), which causes the ...
Sara Frazzetto, Lara Gullo, Gabriele Sapuppo, Manlio Fazio, Cristina Lo Faro, Giuliana Giunta, Ignazio Caravotta, Elisa Mauro, Marina Silvia Parisi, Anna Maria Triolo, Nunziatina Laura Parrinello, Maria Letizia Consoli, Loredana També, Daniela Cambria, Sara Marino, Grazia Scuderi, Francesco Di Raimondo   +16 more
doaj   +2 more sources

An antiviral disulfide compound blocks interaction between arenavirus Z protein and cellular promyelocytic leukemia protein

Biochemical and Biophysical Research Communications, 2010
The promyelocytic leukemia protein (PML) forms nuclear bodies (NB) that can be redistributed by virus infection. In particular, lymphocytic choriomeningitis virus (LCMV) influences disruption of PML NB through the interaction of PML with the arenaviral Z
Ivan Topisirovic, Mahmoud Djavani, Katherine L B Borden   +2 more
exaly   +2 more sources

Promyelocytic Leukemia Protein Controls Cell Migration in Response to Hydrogen Peroxide and Insulin-like Growth Factor-1

Journal of Biological Chemistry, 2010
Promyelocytic leukemia protein (PML) was originally identified as part of a chromosomal translocation that contributes to the development of acute promyelocytic leukemia (APL).
Hung-Ying Kao
exaly   +2 more sources

Promyelocytic leukemia protein is required for gain of function by mutant p53.

Cancer Research, 2009
Mutations in the p53 tumor suppressor are the most common genetic events in human cancer. These mutations not only result in a loss of wild-type p53 activity, but can also lead to a gain of new oncogenic properties.
S. Haupt, Silvia Di Agostino, I. Mizrahi, Osnat Alsheich-Bartok, M. Voorhoeve, A. Damalas, G. Blandino, Y. Haupt   +7 more
semanticscholar   +3 more sources