Results 11 to 20 of about 3,564,161 (186)

Targeting the acute promyelocytic leukemia-associated fusion proteins PML/RARα and PLZF/RARα with interfering peptides. [PDF]

PLoS ONE, 2012
In acute promyelocytic leukemia (APL), hematopoietic differentiation is blocked and immature blasts accumulate in the bone marrow and blood. APL is associated with chromosomal aberrations, including t(15;17) and t(11;17).
Sabine Beez, Philipp Demmer, Elena Puccetti   +2 more
doaj   +2 more sources

PML nuclear body biogenesis and oligomerization-driven leukemogenesis

Blood Science, 2020
. PML nuclear bodies (NBs), which are increasingly recognized as the central hub of many cellular signaling events, are superassembled spherical complexes with diameters of 0.1–2 μm.
Yuwen Li, Xiaodan Ma, Guoyu Meng
doaj   +1 more source

Relationship between FLT3 mutation status, biologic characteristics, and response to targeted therapy in acute promyelocytic leukemia [PDF]

, 2005
The prognostic significance of FLT3 mutations in acute promyelocytic leukemia (APL) is not firmly established and is of particular interest given the opportunities for targeted therapies using FLT3 inhibitors.
Gilkes, Amanda F., Ellen Solomon, Linch, D C, Gale, Rosmary E., Burnett, Alan Kenneth, Gale, RE, David C. Linch, Pizzey, AR, Elizabeth Nugent, Keith Wheatley, Grimwade, D., Grimwade, D, Solomon, E, Pizzey, A R, Solomon, Ellen, Kenneth I. Mills, Swirsky, D, Pizzey, A.R., Burnett, A K, Alan K. Burnett, Hills, Robert Kerrin, Swirsky, David, Kottaridis, Panagiotis D., Grimwade, David, Linch, David C., ?, ?, Hills, R., David Swirsky, Gale, R E, Gilkes, A F, Kottaridis, PD, Solomon, E., Robert Hills, Linch, D.C., Arnold R. Pizzey, Nugent, E., Rosemary E. Gale, Mills, KI, Nugent, Elizabeth, Gale, R.E., Swirsky, D., Hills, Robert, Hills, R, NCRI Adult Leukaemia Working Party, David Grimwade, Kottaridis, P D, Linch, DC, Wheatley, K., Amanda F. Gilkes, Wheatley, Keith, Gilkes, AF, Nugent, E, Panagiotis D. Kottaridis, Mills, K I, Mills, Ken; id_orcid, Kottaridis, P.D., Burnett, AK, Burnett, A.K., Mills, Kenneth I., Gilkes, A.F., Wheatley, K, Pizzey, Arnold R.   +61 more
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Cellulitis with Leukocytopenia as an Initial Sign of Acute Promyelocytic Leukemia

Case Reports in Dermatology, 2012
Patients with hematologic malignancies are immunosuppressive and may develop cutaneous or invasive infections as a primary sign of immune suppression.
Sachiko Sakamoto, Naoki Oiso, Masakatsu Emoto, Shusuke Uchida, Ayaka Hirao, Yoichi Tatsumi, Itaru Matsumura, Akira Kawada   +7 more
doaj   +1 more source

PML isoforms in response to arsenic: high-resolution analysis of PML body structure and degradation [PDF]

, 2014
Arsenic is a clinically effective treatment for acute promyelocytic leukaemia (APL) in which the promyelocytic leukaemia (PML) protein is fused to retinoic receptor alpha (RARα).
Hands, K.J., Hay, Ronald T., Everett, R.D., Hay, R.T., Hands, Katherine J., Cuchet-Lourenco, Delphine, Everett, Roger D., Cuchet-Lourenco, D.   +7 more
core   +1 more source

2-Bromopalmitate targets retinoic acid receptor alpha and overcomes all-trans retinoic acid resistance of acute promyelocytic leukemia

Haematologica, 2019
Fatty acid oxidation dependency of leukemia cells has been documented in recent studies. Pharmacologic inhibition of fatty acid oxidation, thereby, displays significant effects in suppressing leukemia.
Ying Lu, Jin-Song Yan, Li Xia, Kang Qin, Qian-Qian Yin, Hong-Tao Xu, Meng-Qing Gao, Xiao-Ning Qu, Yu-Ting Sun, Guo-Qiang Chen   +9 more
doaj   +1 more source

Entrapment of viral capsids in nuclear PML cages is an intrinsic antiviral host defense against varicella-zoster virus. [PDF]

, 2011
The herpesviruses, like most other DNA viruses, replicate in the host cell nucleus. Subnuclear domains known as promyelocytic leukemia protein nuclear bodies (PML-NBs), or ND10 bodies, have been implicated in restricting early herpesviral gene expression.
Baiker Armin, Sommer, Marvin, Nour Adel M., Sen Nandini, Wang, Li, Leigh Zerboni, Nandini Sen, Reichelt, Mike, Adel M. Nour, Mike Reichelt, Zerboni, Leigh, Marvin Sommer, Perrino, John, Reichelt Mike, Arvin Ann M., Arvin, Ann M., Ann M Arvin, Nour, Adel M., Baiker, Armin, John Perrino, Zerboni Leigh, Ann M. Arvin, Sommer Marvin, Adel M Nour, Perrino John, Li Wang, Armin Baiker, Sen, Nandini, Wang Li   +28 more
core   +2 more sources

Co-operative leukemogenesis in acute myeloid leukemia and acute promyelocytic leukemia reveals C/EBPα as a common target of TRIB1 and PML/RARA

Haematologica, 2016
The PML/RARA fusion protein occurs as a result of the t(15;17) translocation in the acute promyelocytic leukemia subtype of human acute myeloid leukemia.
Karen Keeshan, Pauline Vieugué, Shahzya Chaudhury, Loveena Rishi, Coline Gaillard, Lu Liang, Elaine Garcia, Takuro Nakamura, Nader Omidvar, Scott C. Kogan   +9 more
doaj   +1 more source

A role for cytoplasmic PML in cellular resistance to viral infection. [PDF]

PLoS ONE, 2008
PML gene was discovered as a fusion partner with retinoic acid receptor (RAR) alpha in the t(15:17) chromosomal translocation associated with acute promyelocytic leukemia (APL).
Beth A McNally, Joanne Trgovcich, Gerd G Maul, Yang Liu, Pan Zheng   +4 more
doaj   +1 more source

B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis

Nature Communications, 2019
Promyelocytic leukemia protein (PML) is the scaffolding protein that organizes PML nuclear bodies. Here the authors determine the crystal structure of a PML B1-box multimer and characterise the oligomerisation behaviour of the PML RBCC construct and show
Yuwen Li, Xiaodan Ma, Zhiming Chen, Haiyan Wu, Pengran Wang, Wenyu Wu, Nuo Cheng, Longhui Zeng, Hao Zhang, Xun Cai, Sai-Juan Chen, Zhu Chen, Guoyu Meng   +12 more
doaj   +1 more source