Results 11 to 20 of about 43,079 (212)
Pharmacological Inhibition of BMK1 Suppresses Tumor Growth through Promyelocytic Leukemia Protein [PDF]
Cancer Cell, 2010 BMK1 is activated by mitogens and oncogenic signals and, thus, is strongly implicated in tumorigenesis. We found that BMK1 interacted with promyelocytic leukemia protein (PML), and inhibited its tumor-suppressor function through phosphorylation. Furthermore, activated BMK1 notably inhibited PML-dependent activation of p21.
Yang, Qingkai +8 more
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Promyelocytic leukemia protein targets MK2 to promote cytotoxicity. [PDF]
EMBO Rep, 2021 Promyelocytic leukemia protein (PML) is a tumor suppressor possessing multiple modes of action, including induction of apoptosis. We unexpectedly find that PML promotes necroptosis in addition to apoptosis, with Pml-/- macrophages being more resistant to TNF-mediated necroptosis than wild-type counterparts and PML-deficient mice displaying resistance ...
Chen IT +7 more
europepmc +3 more sources
The promyelocytic leukemia zinc finger protein (PLZF): two decades of molecular oncology [PDF]
Frontiers in Oncology, 2012 The promyelocytic leukemia zinc finger protein (PLZF), also known as Zbtb16 or Zfp145, was first identified in a patient with acute promyelocytic leukemia, where a reciprocal chromosomal translocation t(11;17)(q23;q21) resulted in a fusion with the RARA ...
Bandar Ali Suliman +3 more
doaj +3 more sources
Promyelocytic Leukemia Protein Potently Restricts Human Cytomegalovirus Infection in Endothelial Cells. [PDF]
Int J Mol Sci, 2022 PML nuclear bodies (PML-NBs) are dynamic macromolecular complexes that mediate intrinsic immunity against viruses of different families, including human cytomegalovirus (HCMV). Upon HCMV infection, PML-NBs target viral genomes entering the nucleus and restrict viral immediate–early gene expression by epigenetic silencing.
Seitz S +3 more
europepmc +3 more sources
Promyelocytic Leukemia Proteins Regulate Fanconi Anemia Gene Expression [PDF]
International Journal of Molecular Sciences, 2021 Promyelocytic leukemia (PML) protein is the core component of subnuclear structures called PML nuclear bodies that are known to play important roles in cell survival, DNA damage responses, and DNA repair. Fanconi anemia (FA) proteins are required for repairing interstrand DNA crosslinks (ICLs).
Anudari Munkhjargal +6 more
openaire +3 more sources
Promyelocytic leukemia protein in mesenchymal stem cells is essential for leukemia progression. [PDF]
Ann Hematol, 2018 The dynamic interactions between leukemic cells and cells resident within the bone marrow microenvironment are vital for leukemia progression. The lack of detailed knowledge about the cellular and molecular mechanisms involved in this cross-talk restricts the design of effective treatments. Guarnerio et al.
de Alvarenga EC +5 more
europepmc +4 more sources
Transcriptional Repression by the Promyelocytic Leukemia Protein, PML [PDF]
Experimental Cell Research, 1997 Acute promyelocytic leukemia is characterized by the presence of a t(15; 17) chromosomal translocation which results in the expression of a chimeric gene product, PMLRAR alpha, consisting of an N-terminal-truncated retinoic acid receptor-alpha fused to a C-terminal-truncated PML.
S, Vallian +6 more
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The Promyelocytic Leukemia Protein Represses A20-mediated Transcription [PDF]
Journal of Biological Chemistry, 2002 The promyelocytic leukemia (PML) protein is a tumor suppressor that is disrupted by the chromosomal translocation t(15;17), a consistent cytogenetic feature of acute promyelocytic leukemia. A role of PML in multiple pathways of apoptosis was conclusively demonstrated using PML(-/-) animal and cell culture models.
Wen-Shu, Wu +2 more
openaire +2 more sources
Selective activation of NFAT by promyelocytic leukemia protein [PDF]
Oncogene, 2008 Promyelocytic leukemia (PML) protein is a tumor suppressor with complicated action mechanisms not yet fully understood. In this study, we found that the nuclear factor of activated T cell (NFAT) is an unexpected partner of PML: PML specifically enhanced the transcription activation of NFAT.
Y-H, Lo, C-C, Wu, H-M, Shih, M-Z, Lai
openaire +2 more sources
Promyelocytic Leukemia Protein (PML) Requirement for Interferon-induced Global Cellular SUMOylation. [PDF]
Mol Cell Proteomics, 2018 We report that interferon (IFN) α treatment at short and long periods increases the global cellular SUMOylation and requires the presence of the SUMO E3 ligase promyelocytic leukemia protein (PML), the organizer of PML nuclear bodies (NBs). Several PML isoforms (PMLI-PMLVII) derived from a single PML gene by alternative splicing, share the same N ...
Maroui MA +5 more
europepmc +3 more sources