Results 111 to 120 of about 15,930 (228)
Role PML v ribosomálním stresu [PDF]
, 2019 PML je zapojen do řady buněčných procesů. Je organizátorem subjaderných struktur zvaných jaderná tělíska PML a asociuje s jadérkem při odpovědi na ribozomální stres tvorbou jadérkových struktur PML (PNAs).
Kremserová, Petra
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Allergy, EarlyView.ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter +20 more
wiley +1 more source
The role of PML-II in type I interferon response and gene transcription regulation [PDF]
The promyelocytic leukaemia (PML) gene encodes seven principle protein isoforms due to mRNA alternative splicing; different isoforms have different functions. This study examines the role of PML isoform II (PML-II), in interferon (IFN) and innate immune responses. It was found that siRNA knockdown of PML-II not only inhibited the expression of IFNβ and
openaire
Hidden Symmetry Protection and Topology in Surface Maxwell Waves
, 2022 Since the latter half of the 20th century, the use of metal in optics has become a promising plasmonics field for controlling light at a deep subwavelength scale. Surface plasmon polaritons localized on metal surfaces are crucial in plasmonics.
Miyamaru, Fumiaki +4 more
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Allergy, EarlyView.Imaging mass cytometry shows lupus panniculitis lesions are dominated by cytotoxic and skin‐homing T cells with abundant macrophages and B‐cell aggregates. Spatial neighborhood analysis reveals organized leukocyte architecture, including B‐cell proximity to naïve T cells and M1 macrophages to cytotoxic T cells.
Milad Ameri +11 more
wiley +1 more source
Acta Paediatrica, EarlyView.ABSTRACT Aim Immunocompromised children (IC) were presumed to be at higher risk of SARS‐COV‐2 infection and severe COVID‐19, but population‐based evidence is limited. We assessed infection risk, COVID‐19 hospitalisation, and severe outcomes in IC compared with children with and without other high‐risk conditions.
Costanza Di Chiara +13 more
wiley +1 more source
Conservation Biology, EarlyView.Abstract Knowledge of species distributions is essential for informing policies on nature conservation and restoration. However, updating them on a regular basis and doing so in a harmonized manner at the international level is difficult. The European Bird Census Council integrated national monitoring data covering 5 years to update farmland bird ...
Sergi Herrando +54 more
wiley +1 more source
European Journal of Haematology, EarlyView.SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley +1 more source
The FEBS Journal, EarlyView.Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna +5 more
wiley +1 more source
Journal of Fish Biology, EarlyView.Abstract Electroanaesthesia using electric fish handling gloves induced rapid and reversible sedation of Atlantic mackerel (Scomber scombrus) during surgical tagging without observable adverse effects on behaviour or tag retention. In the laboratory, survival analyses revealed that longer handling times and smaller body sizes significantly reduced ...
Caliyena R. Brown +4 more
wiley +1 more source