Results 91 to 100 of about 15,930 (228)

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

The Grist 1929 [PDF]

, 1929
This is a digitized, downloadable version of the University of Rhode Island yearbook.https://digitalcommons.uri.edu/yearbooks/1023/thumbnail ...
University of Rhode Island
core   +1 more source

Validation of a Multiparametric, Automated, Macroarray‐Based Assay for the Detection of Autoantibodies in Autoimmune Liver Disease

Journal of Clinical Laboratory Analysis, EarlyView.
The assay exploited a multiparametric and fully automated device applied to CHORUS EVO to validate that the CHORUS Macroarray Liver Diseases kit is a novel procedure for detecting autoantibodies of AIH and PBC. The assay resulted as linear, accurate, sensitive, specific, and able to distinguish between PBC and AIH.
Luigi Raganelli, Tommaso Bandini, Matilde Ilacqua, Helena Cerutti, Alessandra Cartocci, Giulia Tesi, Andrea Ianniello, Thomas Massari, Mirko Berretti, Roberto Centini, Michele Norelli, Alessandra Brogi, Giampaola Pesce, Danilo Villalta, Brunetta Porcelli   +14 more
wiley   +1 more source

Mental health measures among adolescents in 12 low‐ and middle‐income countries: Measurement invariance and cross‐sectional analyses of Disrupting Harm survey data

JCPP Advances, EarlyView.
Abstract Background Nationally representative mental health data in adolescents from low‐ and middle‐income countries (LMICs) are scarce. This study aimed to examine mental health and wellbeing indicators amongst adolescents in 12 LMICs across Eastern and Southern Africa and Southeast Asia. Methods We conducted a secondary analysis of data involving 12,
Ariadna Albajara Sáenz, Sebastian Kurten, Jennifer Saxton, Daniel Kardefelt‐Winther, Tamsin Ford, Amy Orben, Simon R. White   +6 more
wiley   +1 more source

Generation of JC Polyoma Pseudovirus for High-Throughput Measurement of Neutralizing Antibodies

Diagnostics
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system (CNS) caused by reactivation of dormant JC polyomavirus (JCPyV).
Mami Matsuda, Tian-Cheng Li, Akira Nakanishi, Kazuo Nakamichi, Makoto Saito, Tadaki Suzuki, Tomokazu Matsuura, Masamichi Muramatsu, Tetsuro Suzuki, Yoshiharu Miura, Ryosuke Suzuki   +10 more
doaj   +1 more source

INVESTIGATING THE MECHANISM OF THE COMPARTMENTALIZED CBP (CREB-BINDING PROTEIN) UBIQUITIN LIGASE ACTIVITIES [PDF]

, 2016
CBP (CREB Binding Protein) is global transcriptional co-activator and histone acetyltransferase. CBP is involved in the modulation of the transcription of many genes via histone acetylation at the promoter regions of the target genes.
Akande, Oluwatoyin E
core   +1 more source

Efficient First‐Principles Inverse Design of Nanolasers

Laser &Photonics Reviews, EarlyView.
This article introduces a first‐principles inverse‐design framework for nanolasers that directly incorporates nonlinear lasing physics. By unifying steady‐state ab‐initio laser theory (SALT) with topology optimization, it reveals how spatial hole burning, gain saturation, and cavity‐emitter coupling shape laser performance, enabling efficient discovery
Beñat Martinez de Aguirre Jokisch, Alexander Cerjan, Rasmus Ellebæk Christiansen, Jesper Mørk, Ole Sigmund, Steven G. Johnson   +5 more
wiley   +1 more source

Influence of the host cell factors CK2, hTERT, and PML, on the antiviral response to herpes simplex virus type I infection [PDF]

, 2013
Herpes simplex virus type I (HSV-1) is a significant human pathogen that infects a large portion of the human population. As an obligate intracellular parasite, HSV-1 requires certain cellular factors for its replication; on the other hand, the cell ...
Smith, Miles Christian
core  

Dipole‐Quadrupole Model and Multipole Analysis of Resonant Membrane Metasurfaces

Laser &Photonics Reviews, EarlyView.
Membrane metasurfaces, arrays of holes in a dielectric membrane, are appealing because they require no substrate and allow access to resonant near‐fields. However, developing a comprehensive theoretical description for them remains challenging. We introduce a semi‐analytical dipole‐quadrupole approach to analyze their resonant spectra at arbitrary ...
Izzatjon Allayarov, Andrey B. Evlyukhin, Antonio Calà Lesina   +2 more
wiley   +1 more source

Optical Skyrmions with Tunable or Reconfigurable Topology Using Spin‐Decoupled Metaoptics

Laser &Photonics Reviews, EarlyView.
The work introduces advanced optical elements capable of generating and dynamically reconfiguring complex light patterns known as optical skyrmions. By precisely shaping light polarization at the nanoscale, a single engineered metasurface can generate and manipulate robust and tunable polarization textures in an efficient and scalable way.
Andrea Vogliardi, Daniele Bonaldo, Simone Dal Zilio, Vittorio Apolloni, Filippo Romanato, Gianluca Ruffato   +5 more
wiley   +1 more source