Results 71 to 80 of about 15,930 (228)

Multiscale Architecture and Mechanics of the Cell Nucleus: Implications for Disease, Bioengineering and Nanomedicine

Advanced Science, EarlyView.
Nuclear mechanical properties are inherently scale‐dependent, arising from a hierarchical architecture that spans DNA, chromatin, the nuclear envelope, and condensates. Experimental techniques and theoretical models are integrated into a cohesive multiscale framework linking nanoscale structural features to organelle‐level mechanical behavior.
Xinran Liu, Xin Chen, Qingyang Zhao, Weikang Tan, Lingrui Zhu, Kin Liao, Vincent Chan, Nicolae Goga, Winfred O. Larkotey, Yang Li, Yinghui Shi, Wenya Shu, Lin Wang, Weiqing Wang, Tian Jian Lu, Yulong Han   +15 more
wiley   +1 more source

PHRF1 promotes migration and invasion by modulating ZEB1 expression.

PLoS ONE, 2020
PHRF1 (PHD and RING finger domain-containing protein 1) suppresses acute promyelocytic leukemia (APL) by promoting TGIF (TG-interacting factor) ubiquitination, while the PML-RARα protein interferes with PHRF1-mediated TGIF breakdown to facilitate APL ...
Jin-Yu Lee, Chih-Chen Fan, Nai-Lin Chou, Hung-Wei Lin, Mau-Sun Chang   +4 more
doaj   +1 more source

Critical soil moisture detection and water–energy limit shift attribution using satellite-based water and carbon fluxes over China [PDF]

Hydrology and Earth System Sciences
Critical soil moisture (CSM), a tipping point of soil moisture (SM) at which surface fluxes shift from the energy-limited regime to the water-limited regime, is essential for the vegetation state and the corresponding land–atmosphere coupling.
Y. Liu, J. Xiao, X. Li, Y. Li
doaj   +1 more source

Safety and Feasibility of On-the-Table Pharmacomechanical Lysis for Acute Intermediate-Risk Pulmonary Embolism

JACC: Advances
Background: Acute pulmonary embolism (PE) is a leading cause of morbidity and mortality. Pharmacomechanical lysis (PML) with the Bashir endovascular catheter has been shown to reduce the right ventricular/left ventricular (RV/LV) ratio in patients with ...
Vladimir Lakhter, DO, Christian Bichard, MD, Kenneth Ouriel, MD, Brian Firth, MD, Parth Rali, MD, Riyaz Bashir, MD   +5 more
doaj   +1 more source

The coelurosaur theropods of the Romualdo formation, early Cretaceous (Aptian) of Brazil: Santanaraptor placidus meets Mirischia asymmetrica

The Anatomical Record, EarlyView.
Abstract The upper carbonate concretion levels of the Romualdo Formation (Aptian, Brazil) have yielded several theropod dinosaur remains, including spinosaurids and the coelurosaurs Santanaraptor placidus and Mirischia asymmetrica, the phylogenetic affinities of which are controversial.
Rafael Delcourt, Orlando Nelson Grillo, Christophe Hendrickx, Maximilian Kellermann, Max Cardoso Langer   +4 more
wiley   +1 more source

RNA/MBNL1-containing foci in myoblast nuclei from patients affected by myotonic dystrophy type 2: an immunocytochemical study

European Journal of Histochemistry, 2009
Myotonic dystrophy type 2 (DM2) is a dominantly inherited autosomal disease with multi-systemic clinical features and it is caused by expansion of a CCTG tetranucleotide repeat in the first intron of the zinc finger protein 9 (ZNF9) gene in 3q21.The ...
F. Perdoni, M. Malatesta, R. Cardani, M. Giagnacovo, E. Mancinelli, G. Meola, C. Pellicciari   +6 more
doaj   +3 more sources

Die Rolle der PML-Kernkörperchen bei der Regulation der MHC Klasse II-Expression [PDF]

, 2011
Die Regulation der Lokalisation von Genen im Zellkern ist ein wichtiges Transkriptions-Kontrollelement in Eukaryoten. Für Wirbeltierzellen konnte gezeigt werden, dass bestimmte Gene mit Kernkörperchen assoziieren, wodurch möglicherweise deren ...
Ulbricht, Tobias
core  

The internal crest anatomy of Lambeosaurini (Hadrosauridae: Lambeosaurinae)

The Anatomical Record, EarlyView.
Abstract The supracranial crests of lambeosaurine hadrosaurids have long been a focus of study due primarily to their extreme morphology. The external anatomy of lambeosaurine crests is understood to be highly variable between species, but variation in their internal anatomy is less well understood.
Thomas W. Dudgeon, Courtney Brown, David C. Evans   +2 more
wiley   +1 more source

The Grizzly, September 13, 1994 [PDF]

, 1994
Budget Concerns Discussed • The Search Continues • Convocation Opens Academic Year • Military Action Likely • U.S. Relations with Cuba • Sculptures, Sculptures Everywhere • All Lines Busy • Capital Improvements • Excellence Should not be Overlooked ...
Blocksidge, Jayson, Davenport, Amy K., Ellman, Marc, Gaft, David, Geiger, Brad, Kindt, Jason, Le, Richard, Leiser, Mark, Mastrangelo, Tom, Piraino, Stephanie, Plitt, Doug, Qasim, Tarik, Rinehimer, Hope, Tucker, Colin, Weingroff, Charlie   +14 more
core   +1 more source

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source