Results 11 to 20 of about 46,902 (263)
PML degradation: multiple ways to eliminate PML. [PDF]
Frontiers in Oncology, 2013 The promyelocytic leukemia gene (PML) critically regulates several cellular functions that oppose tumorigenesis such as oncogene-induced senescence, apoptosis, the response to DNA damage and to viral infections.
Andrea eRabellino, Pier Paolo eScaglioni
doaj +5 more sources
PML-II regulates ERK and AKT signal activation and IFNα-induced cell death
Cell Communication and Signaling, 2021 Background The requirement of promyelocytic leukaemia protein (PML) in interferon (IFN)-induced cell apoptosis is well-established. However, the exact mechanisms by which the multiple isoforms of PML protein participate in this process remain not well ...
Xueqiong Meng +3 more
doaj +7 more sources
Regulation of apoptosis by PML and the PML-NBs [PDF]
Oncogene, 2008 The promyelocytic leukemia protein (PML) is a tumor suppressor identified in acute PML and implicated in the pathogenesis of a variety of tumors. PML is essential for the proper assembly of a nuclear macromolecular structure called the PML nuclear body (PML-NB).
Antonella Papa +2 more
exaly +4 more sources
Regulation of NF-κB by PML and PML-RARα [PDF]
Scientific Reports, 2017 AbstractPromyelocytic Leukemia (PML) is a nuclear protein that forms sub-nuclear structures termed nuclear bodies associated with transcriptionally active genomic regions. PML is a tumour suppressor and regulator of cell differentiation. We demonstrate that PML promotes TNFα-induced transcriptional responses by promoting NF-κB activity.
Ahmed, Abrar +8 more
openaire +5 more sources
Metabolic profiles by 1H-magnetic resonance spectroscopy in natalizumab-associated post-PML lesions of multiple sclerosis patients who survived progressive multifocal leukoencephalopathy (PML). [PDF]
PLoS ONE, 2017 PURPOSE:Early diagnosis and treatment of multiple sclerosis-related progressive multifocal leukoencephalopathy (PML) significantly improve clinical outcomes. However, there is a lack of information regarding the restart of immunomodulatory therapy in the
Ruth Schneider +7 more
doaj +4 more sources
PML, SUMOylation, and Senescence [PDF]
Frontiers in Oncology, 2013 Since its discovery, 25 years ago, promyelocytic leukemia (PML) has been an enigma. Implicated in the oncogenic PML/RARA fusion, forming elusive intranuclear domains, triggering cell death or senescence, controlled by and perhaps controlling SUMOylation… there are multiple PML-related issues.
Hugues eDe Thé +10 more
openaire +5 more sources
Gene Expression of Promyelocytic Leukemia Proteins and IFN-γ Is Reduced in Rotavirus-Infected Children [PDF]
Iranian Biomedical Journal, 2020 Background: Rotavirus infection is one of the most common gastroenteritis in the world, and a million cases are registered to enter hospital every year.
Ahmed Jasim Mohammed +2 more
doaj +2 more sources
Environmental Evidence, 2021 Background Numerous man-made structures (MMS) have been installed in various parts of the ocean (e.g. oil and gas structures, offshore wind installations). Many are now at, or nearing, the end of their intended life.
Anaëlle J. Lemasson +9 more
doaj +1 more source
Metals, 2022 Metal matrix composites are a class of materials with high potential for industrial application due to the multifaceted properties that they possess. In the present research, mechanical alloying via ball milling was used to produce AA2024 powder that was
Fani Stergioudi +4 more
doaj +1 more source
Environmental Evidence, 2022 Background Many marine man-made structures (MMS), such as oil and gas platforms or offshore wind turbines, are nearing their ‘end-of-life’ and require decommissioning.
Anaëlle J. Lemasson +9 more
doaj +1 more source