Metabolic profiles by 1H-magnetic resonance spectroscopy in natalizumab-associated post-PML lesions of multiple sclerosis patients who survived progressive multifocal leukoencephalopathy (PML). [PDF]
PLoS ONE, 2017 PURPOSE:Early diagnosis and treatment of multiple sclerosis-related progressive multifocal leukoencephalopathy (PML) significantly improve clinical outcomes. However, there is a lack of information regarding the restart of immunomodulatory therapy in the
Ruth Schneider +7 more
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PML, SUMOylation, and Senescence [PDF]
Frontiers in Oncology, 2013 Since its discovery, 25 years ago, promyelocytic leukemia (PML) has been an enigma. Implicated in the oncogenic PML/RARA fusion, forming elusive intranuclear domains, triggering cell death or senescence, controlled by and perhaps controlling SUMOylation… there are multiple PML-related issues.
Hugues eDe Thé +10 more
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PML-II regulates ERK and AKT signal activation and IFNα-induced cell death
Cell Communication and Signaling, 2021 Background The requirement of promyelocytic leukaemia protein (PML) in interferon (IFN)-induced cell apoptosis is well-established. However, the exact mechanisms by which the multiple isoforms of PML protein participate in this process remain not well ...
Xueqiong Meng +3 more
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Metals, 2022 Metal matrix composites are a class of materials with high potential for industrial application due to the multifaceted properties that they possess. In the present research, mechanical alloying via ball milling was used to produce AA2024 powder that was
Fani Stergioudi +4 more
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PML isoforms in response to arsenic: high-resolution analysis of PML body structure and degradation [PDF]
, 2014 Arsenic is a clinically effective treatment for acute promyelocytic leukaemia (APL) in which the promyelocytic leukaemia (PML) protein is fused to retinoic receptor alpha (RARα).
Hands, K.J. +7 more
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ALIGNMENT OF HYPERSPECTRAL IMAGERY AND FULL-WAVEFORM LIDAR DATA FOR VISUALISATION AND CLASSIFICATION PURPOSES [PDF]
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2015 The overarching aim of this paper is to enhance the visualisations and classifications of airborne remote sensing data for remote forest surveys. A new open source tool is presented for aligning hyperspectral and full-waveform LiDAR data.
M. Miltiadou +3 more
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The PML domain of PML–RARα blocks senescence to promote leukemia [PDF]
Proceedings of the National Academy of Sciences, 2014 Significance Acute promyelocytic leukemia (APL) is a model for oncoprotein-targeted therapy because induced degradation of the promyelocytic leukemia protein–retinoic acid receptor (PML–RAR) fusion protein by retinoic acid and arsenic trioxide essentially eradicates the disease.
Katharina, Korf +13 more
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Entrapment of viral capsids in nuclear PML cages is an intrinsic antiviral host defense against varicella-zoster virus. [PDF]
, 2011 The herpesviruses, like most other DNA viruses, replicate in the host cell nucleus. Subnuclear domains known as promyelocytic leukemia protein nuclear bodies (PML-NBs), or ND10 bodies, have been implicated in restricting early herpesviral gene expression.
Baiker Armin +28 more
core +1 more source
Журнал инфектологии, 2019 Progressive multifocal leukoencephalopathy (PML) is one of the most severe opportunistic diseases of the central nervous system, which leads to multiple demyelination of brain structures, neurological symptoms and frequent death or disability of the ...
E. A. Samotolkina +3 more
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Application of the Reflectionless Discrete Perfectly Matched Layer for Acoustic Wave Simulation
Frontiers in Earth Science, 2022 The perfectly matched layer (PML) is one of the most popular absorbing boundary conditions for simulating seismic waves. In theory, the PML can absorb incident waves at any incident angle and any frequency in a medium. However, numerical reflections will
Yingjie Gao +3 more
doaj +1 more source