Results 31 to 40 of about 46,902 (263)
Application of the Reflectionless Discrete Perfectly Matched Layer for Acoustic Wave Simulation
Frontiers in Earth Science, 2022 The perfectly matched layer (PML) is one of the most popular absorbing boundary conditions for simulating seismic waves. In theory, the PML can absorb incident waves at any incident angle and any frequency in a medium. However, numerical reflections will
Yingjie Gao +3 more
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The PML domain of PML–RARα blocks senescence to promote leukemia [PDF]
Proceedings of the National Academy of Sciences, 2014 Significance Acute promyelocytic leukemia (APL) is a model for oncoprotein-targeted therapy because induced degradation of the promyelocytic leukemia protein–retinoic acid receptor (PML–RAR) fusion protein by retinoic acid and arsenic trioxide essentially eradicates the disease.
Katharina, Korf +13 more
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Promyelocytic leukemia nuclear body-like structures can assemble in mouse oocytes
Biology Open, 2022 Promyelocytic leukemia (PML) nuclear bodies (PML-NBs), a class of membrane-less cellular organelles, participate in various biological activities. PML-NBs are known as the core-shell-type nuclear body, harboring ‘client’ proteins in their core.
Osamu Udagawa +2 more
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Perspectives in PML: a unifying framework for PML function
Frontiers in Bioscience, 2009 The promyeloctyic leukemia protein (PML) has established activities as a potent repressor of proliferation, and oncogenic transformation, a promoter of apoptosis, an inducer of senescence, and may act as an inhibitor of angiogenesis in mammalian systems. Loss of PML or its nuclear bodies is associated with many human disease states.
Katherine L B, Borden +1 more
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PML degradation fosters an immunosuppressive and pro-metastatic tumor microenvironment
Molecular & Cellular Oncology, 2017 The tumor suppressive functions of promyelocytic leukemia (PML) have been attributed mainly to its inhibition of various malignant properties of tumor cells.
Ya-Ting Wang, Ruey-Hwa Chen
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Журнал инфектологии, 2019 Progressive multifocal leukoencephalopathy (PML) is one of the most severe opportunistic diseases of the central nervous system, which leads to multiple demyelination of brain structures, neurological symptoms and frequent death or disability of the ...
E. A. Samotolkina +3 more
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SUMO pathway dependent recruitment of cellular repressors to herpes simplex virus type 1 genomes [PDF]
, 2011 Components of promyelocytic leukaemia (PML) nuclear bodies (ND10) are recruited to sites associated with herpes simplex virus type 1 (HSV-1) genomes soon after they enter the nucleus. This cellular response is linked to intrinsic antiviral resistance and
Delphine Cuchet-Lourenço +24 more
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Cells, 2019 Promyelocytic leukemia (PML) bodies are dynamic intracellular structures that recruit and release a variety of different proteins in response to stress, virus infection, DNA damage and cell cycle progression. While PML bodies primarily are regarded as nuclear compartments, they are forced to travel to the cytoplasm each time a cell divides, due to ...
Anna Lång, Emma Lång, Stig Ove Bøe
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Solution of a P and S wave propagation model using high performance computation
CT&F Ciencia, Tecnología & Futuro, 2019 The propagation of seismic waves is affected by the type of transmission media. Therefore, it is necessary to solve a differential equation system in partial derivatives allowing for identification of waves propagating into an elastic media.
Jonathan Amado +3 more
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Patient monitoring during treatment with natalizumab (ORP-24) [PDF]
Neurology Letters, 2023 Natalizumab (Tysabri), a recombinant humanized monoclonal antibody selective for α4- integrin, is indicated for CIS, RRMS, and active SPMS in adults.
Zohreh Abna
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