Results 31 to 40 of about 42,451 (299)
International Journal for Numerical Methods in Engineering, 2011 SUMMARYThis brief article outlines a new and rather simple method for obtaining the finite element matrices for a perfectly matched layer used for elastic wave propagation in the context of a frequency‐domain formulation. For this purpose, we introduce a fairly mild simplification, which allows applying the stretching functions directly to the mass and
Kausel, Eduardo A. +1 more
openaire +4 more sources
PML degradation fosters an immunosuppressive and pro-metastatic tumor microenvironment
Molecular & Cellular Oncology, 2017 The tumor suppressive functions of promyelocytic leukemia (PML) have been attributed mainly to its inhibition of various malignant properties of tumor cells.
Ya-Ting Wang, Ruey-Hwa Chen
doaj +1 more source
Effects of arsenic on the topology and solubility of promyelocytic leukemia (PML)-nuclear bodies.
PLoS ONE, 2022 Promyelocytic leukemia (PML) proteins are involved in the pathogenesis of acute promyelocytic leukemia (APL). Trivalent arsenic (As3+) is known to cure APL by binding to cysteine residues of PML and enhance the degradation of PML-retinoic acid receptor α
Seishiro Hirano, Osamu Udagawa
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PML and PML-like exonucleases restrict retrotransposons in jawed vertebrates
Nucleic Acids Research, 2022 ABSTRACT We have uncovered a novel role for the promyelocytic leukemia ( PML ) gene and novel PML-like DEDDh exonucleases in the maintenance of genome stability through the restriction of LINE-1 (L1) retrotransposition in jawed vertebrates. Although the PML tumour suppressor protein
Sabateeshan Mathavarajah +12 more
openaire +2 more sources
No evidence of beneficial effects of plasmapheresis in natalizumab-associated PML [PDF]
, 2017 OBJECTIVE: To examine retrospectively the effects of plasmapheresis (PLEX) on the survival and clinical outcomes of patients with multiple sclerosis (MS) and natalizumab (NTZ)-associated progressive multifocal leukoencephalopathy (PML).
Sormani, Maria Pia +39 more
core +3 more sources
Frontiers in Veterinary Science, 2021 Promyelocytic leukemia (PML) protein is a crucial component of PML-nuclear bodies (PML-NBs). PML and PML-NBs are involved in the regulation of various cellular functions, including the antiviral immune response.
Jingjing Zhu +7 more
doaj +1 more source
Cold Spring Harbor Perspectives in Biology, 2010 PML nuclear bodies are matrix-associated domains that recruit an astonishing variety of seemingly unrelated proteins. Since their discovery in the early 1960s, PML bodies have fascinated cell biologists because of their beauty and their tight association with cellular disorders.
Lallemand-Breitenbach, Valérie +1 more
openaire +2 more sources
A viral ubiquitin ligase has substrate preferential SUMO targeted ubiquitin ligase activity that counteracts intrinsic antiviral defence [PDF]
, 2011 Intrinsic antiviral resistance represents the first line of intracellular defence against virus infection. During herpes simplex virus type-1 (HSV-1) infection this response can lead to the repression of viral gene expression but is counteracted by the ...
Delphine Cuchet-Lourenço +21 more
core +1 more source
, 2012 In acute promyelocytic leukemia (APL), hematopoietic differentiation is blocked and immature blasts accumulate in the bone marrow and blood. APL is associated with chromosomal aberrations, including t(15;17) and t(11;17).
Sabine Beez (123610) +8 more
core +1 more source
The p97/VCP segregase is essential for arsenic induced degradation of PML and PML-RARA [PDF]
, 2023 Acute Promyelocytic Leukemia is caused by expression of the oncogenic Promyelocytic Leukemia (PML)–Retinoic Acid Receptor Alpha (RARA) fusion protein.
Tatham, Michael H. +7 more
core +1 more source