The helicase HAGE prevents interferon-a-induced PML expression in ABCB5+ malignant melanoma-initiating cells by promoting the expression of SOCS1 [PDF]
, 2014 The tumour suppressor PML (promyelocytic leukaemia protein) regulates several cellular pathways involving cell growth, apoptosis, differentiation and senescence.
A Carracedo +33 more
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Metabolic profiles by 1H-magnetic resonance spectroscopy in natalizumab-associated post-PML lesions of multiple sclerosis patients who survived progressive multifocal leukoencephalopathy (PML). [PDF]
PLoS ONE, 2017 PURPOSE:Early diagnosis and treatment of multiple sclerosis-related progressive multifocal leukoencephalopathy (PML) significantly improve clinical outcomes. However, there is a lack of information regarding the restart of immunomodulatory therapy in the
Ruth Schneider +7 more
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Effects of arsenic on the topology and solubility of promyelocytic leukemia (PML)-nuclear bodies.
PLoS ONE, 2022 Promyelocytic leukemia (PML) proteins are involved in the pathogenesis of acute promyelocytic leukemia (APL). Trivalent arsenic (As3+) is known to cure APL by binding to cysteine residues of PML and enhance the degradation of PML-retinoic acid receptor α
Seishiro Hirano, Osamu Udagawa
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Identifying gene locus associations with promyelocytic leukemia nuclear bodies using immuno-TRAP. [PDF]
, 2013 Important insights into nuclear function would arise if gene loci physically interacting with particular subnuclear domains could be readily identified.
Ahmed, Kashif +4 more
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Perspectives in PML: a unifying framework for PML function
Frontiers in Bioscience, 2009 The promyeloctyic leukemia protein (PML) has established activities as a potent repressor of proliferation, and oncogenic transformation, a promoter of apoptosis, an inducer of senescence, and may act as an inhibitor of angiogenesis in mammalian systems. Loss of PML or its nuclear bodies is associated with many human disease states.
Katherine L B, Borden +1 more
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Frontiers in Veterinary Science, 2021 Promyelocytic leukemia (PML) protein is a crucial component of PML-nuclear bodies (PML-NBs). PML and PML-NBs are involved in the regulation of various cellular functions, including the antiviral immune response.
Jingjing Zhu +7 more
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The SUMO Ligase Protein Inhibitor of Activated STAT 1 (PIAS1) is a constituent PML-NB protein that contributes to the intrinsic antiviral immune response to herpes simplex virus 1 (HSV-1) [PDF]
, 2016 Aspects of intrinsic antiviral immunity are mediated by promyelocytic leukaemia (PML)-nuclear body (PML-NB) constituent proteins. During herpesvirus infection, these antiviral proteins are independently recruited to nuclear domains that contain infecting
Boutell, Chris +7 more
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PML inspired transparent metamaterials [PDF]
2016 IEEE International Symposium on Antennas and Propagation (APSURSI), 2016 Perfectly transparent metamaterial structures of arbitrary shapes, constructed from coordinate stretching and contractions, are presented. Coordinate stretching has been used for 2 decades in perfectly matched layers (PMLs) to electromagnetically simulate infinite domains in numerical techniques, but this concept is applied here for the first time to ...
Chamanara, Nima, Caloz, Christophe
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Divergence rates of Markov order estimators and their application to statistical estimation of stationary ergodic processes [PDF]
, 2013 Stationary ergodic processes with finite alphabets are estimated by finite memory processes from a sample, an n-length realization of the process, where the memory depth of the estimator process is also estimated from the sample using penalized maximum ...
Talata, Zsolt
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Cells, 2019 Promyelocytic leukemia (PML) bodies are dynamic intracellular structures that recruit and release a variety of different proteins in response to stress, virus infection, DNA damage and cell cycle progression. While PML bodies primarily are regarded as nuclear compartments, they are forced to travel to the cytoplasm each time a cell divides, due to ...
Anna Lång, Emma Lång, Stig Ove Bøe
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