Results 31 to 40 of about 36,450 (302)

Metabolic profiles by 1H-magnetic resonance spectroscopy in natalizumab-associated post-PML lesions of multiple sclerosis patients who survived progressive multifocal leukoencephalopathy (PML). [PDF]

PLoS ONE, 2017
PURPOSE:Early diagnosis and treatment of multiple sclerosis-related progressive multifocal leukoencephalopathy (PML) significantly improve clinical outcomes. However, there is a lack of information regarding the restart of immunomodulatory therapy in the
Ruth Schneider, Barbara Bellenberg, Robert Hoepner, Eva-Maria Kolb, Gisa Ellrichmann, Aiden Haghikia, Ralf Gold, Carsten Lukas   +7 more
doaj   +1 more source

Effects of arsenic on the topology and solubility of promyelocytic leukemia (PML)-nuclear bodies.

PLoS ONE, 2022
Promyelocytic leukemia (PML) proteins are involved in the pathogenesis of acute promyelocytic leukemia (APL). Trivalent arsenic (As3+) is known to cure APL by binding to cysteine residues of PML and enhance the degradation of PML-retinoic acid receptor α
Seishiro Hirano, Osamu Udagawa
doaj   +1 more source

PML and PML-like exonucleases restrict retrotransposons in jawed vertebrates

Nucleic Acids Research, 2022
ABSTRACT We have uncovered a novel role for the promyelocytic leukemia ( PML ) gene and novel PML-like DEDDh exonucleases in the maintenance of genome stability through the restriction of LINE-1 (L1) retrotransposition in jawed vertebrates. Although the PML tumour suppressor protein
Sabateeshan Mathavarajah, Kathleen L. Vergunst, Shelby K. Williams, Raymond He, Maria Maliougina, Elias B. Habib, Mika Park, Jayme Salsman, Stéphane Roy, Ingo Braasch, Andrew J. Roger, David N. Langelaan, Graham Dellaire   +12 more
openaire   +2 more sources

PML Nuclear Bodies [PDF]

Cold Spring Harbor Perspectives in Biology, 2010
PML nuclear bodies are matrix-associated domains that recruit an astonishing variety of seemingly unrelated proteins. Since their discovery in the early 1960s, PML bodies have fascinated cell biologists because of their beauty and their tight association with cellular disorders.
Lallemand-Breitenbach, Valérie, de Thé, H.   +1 more
openaire   +2 more sources

Molecular Cloning of Alternative Splicing Variants of the Porcine PML Gene and Its Expression Patterns During Japanese Encephalitis Virus Infection

Frontiers in Veterinary Science, 2021
Promyelocytic leukemia (PML) protein is a crucial component of PML-nuclear bodies (PML-NBs). PML and PML-NBs are involved in the regulation of various cellular functions, including the antiviral immune response.
Jingjing Zhu, Zhenyu Chen, Zhenglie Dai, Xiaolong Zhou, Han Wang, Xiangchen Li, Ayong Zhao, Songbai Yang   +7 more
doaj   +1 more source

Role of PML and PML-RARα in Mad-Mediated Transcriptional Repression [PDF]

Molecular Cell, 2001
Fusion of the promyelocytic leukemia (PML) protein to the retinoic acid receptor-alpha (RARalpha) generates the transforming protein of acute promyelocytic leukemias. PML appears to be involved in multiple functions, including apoptosis and transcriptional activation by RAR, whereas PML-RARalpha blocks these functions of PML. However, the mechanisms of
Khan, Md Matiullah, Nomura, Teruaki, Kim, Hyungtae, Kaul, Sunil C., Wadhwa, Renu, Shinagawa, Toshie, Ichikawa-Iwata, Emi, Zhong, Sue, Pandolfi, Pier Paolo, Ishii, Shunsuke   +9 more
openaire   +2 more sources

Pemodelan Awal Ground Penetrating Radar dengan Metode Discontinuous Galerkin dan PML Berenger

Jurnal Nasional Teknik Elektro dan Teknologi Informasi, 2016
This paper discusses the development of Discontinuous Galerkin method, which has both linear shape function and weight function, for modeling Ground Penetrating Radar (GPR) in heterogeneous media.
Pranowo
doaj   +1 more source

The Role of Promyelocytic Leukemia Nuclear Bodies During HPV Infection

Frontiers in Cellular and Infection Microbiology, 2020
Promyelocytic leukemia (PML) nuclear bodies (NBs) are highly dynamic subnuclear structures. Their name giving major component, PML protein, is essential for their formation.
Lucile G. Guion, Lucile G. Guion, Martin Sapp, Martin Sapp   +3 more
doaj   +1 more source

A Tale of Usurpation and Subversion: SUMO-Dependent Integrity of Promyelocytic Leukemia Nuclear Bodies at the Crossroad of Infection and Immunity

Frontiers in Cell and Developmental Biology, 2021
Promyelocytic leukemia nuclear bodies (PML NBs) are multi-protein assemblies representing distinct sub-nuclear structures. As phase-separated molecular condensates, PML NBs exhibit liquid droplet-like consistency.
Upayan Patra, Stefan Müller
doaj   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source