Results 51 to 60 of about 46,902 (263)
No evidence of beneficial effects of plasmapheresis in natalizumab-associated PML [PDF]
, 2017 OBJECTIVE: To examine retrospectively the effects of plasmapheresis (PLEX) on the survival and clinical outcomes of patients with multiple sclerosis (MS) and natalizumab (NTZ)-associated progressive multifocal leukoencephalopathy (PML).
Sormani, Maria Pia +39 more
core +3 more sources
The PML for rough surface scattering [PDF]
, 2009 In this paper we investigate the use of the perfectly matched layer (PML) to truncate a time harmonic rough surface scattering problem in the direction away from the scatterer.
Chandler-Wilde, Simon Neil, Monk, Peter
core +1 more source
Role of PML and PML-RARα in Mad-Mediated Transcriptional Repression [PDF]
Molecular Cell, 2001 Fusion of the promyelocytic leukemia (PML) protein to the retinoic acid receptor-alpha (RARalpha) generates the transforming protein of acute promyelocytic leukemias. PML appears to be involved in multiple functions, including apoptosis and transcriptional activation by RAR, whereas PML-RARalpha blocks these functions of PML. However, the mechanisms of
Khan, Md Matiullah +9 more
openaire +2 more sources
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
Pemodelan Awal Ground Penetrating Radar dengan Metode Discontinuous Galerkin dan PML Berenger
Jurnal Nasional Teknik Elektro dan Teknologi Informasi, 2016 This paper discusses the development of Discontinuous Galerkin method, which has both linear shape function and weight function, for modeling Ground Penetrating Radar (GPR) in heterogeneous media.
Pranowo
doaj +1 more source
The Role of Promyelocytic Leukemia Nuclear Bodies During HPV Infection
Frontiers in Cellular and Infection Microbiology, 2020 Promyelocytic leukemia (PML) nuclear bodies (NBs) are highly dynamic subnuclear structures. Their name giving major component, PML protein, is essential for their formation.
Lucile G. Guion +3 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Promyelocytic leukemia nuclear bodies (PML NBs) are multi-protein assemblies representing distinct sub-nuclear structures. As phase-separated molecular condensates, PML NBs exhibit liquid droplet-like consistency.
Upayan Patra, Stefan Müller
doaj +1 more source
Differential Roles of PML Isoforms [PDF]
Frontiers in Oncology, 2013 The tumor suppressor promyelocytic leukemia (PML) protein is fused to the retinoic acid receptor alpha in patients suffering from acute promyelocytic leukemia (APL). Treatment of APL patients with arsenic trioxide (As2O3) reverses the disease phenotype by a process involving the degradation of the fusion protein via its PML moiety. Several PML isoforms
Sébastien eNisole +7 more
openaire +3 more sources
PML-nuclear body formation is impaired in deletion mutant PML-RARA-expressing cells.
, 2018 (A) PML/RARA degradation upon RA treatment in Wt-PML-RARA- and mutant-PML-RARA-transduced cells was analyzed by Western blot using anti-FLAG antibody. The cells were treated with 1 μM of ATRA or tamibarotene for 12 hours.
Yohei Yamaguchi (716799) +13 more
core +1 more source
Relationship between FLT3 mutation status, biologic characteristics, and response to targeted therapy in acute promyelocytic leukemia [PDF]
, 2005 The prognostic significance of FLT3 mutations in acute promyelocytic leukemia (APL) is not firmly established and is of particular interest given the opportunities for targeted therapies using FLT3 inhibitors.
Gilkes, Amanda F. +61 more
core +1 more source