Results 41 to 50 of about 46,902 (263)

A Collaborative Approach to Addressing PML: The PML Consortium [PDF]

Journal of Multiple Sclerosis, 2013
Progressive multifocal leukoencephalopathy (PML) is a rare but severe and often fatal disease of the central nervous system most commonly associated with severe immunodeficiency. PML occurs in many clinical conditions as shown in the table below (Table 1) [1-23]. The greatest number of PML cases occurs as a sequel to HIV infection.
William O. Iverson, Dejan Pavlovic, Ilse Peterson   +2 more
openaire   +1 more source

PMLs: A direct approach [PDF]

International Journal for Numerical Methods in Engineering, 2011
SUMMARYThis brief article outlines a new and rather simple method for obtaining the finite element matrices for a perfectly matched layer used for elastic wave propagation in the context of a frequency‐domain formulation. For this purpose, we introduce a fairly mild simplification, which allows applying the stretching functions directly to the mass and
Kausel, Eduardo A., Oliveira Barbosa, Joao Manuel de   +1 more
openaire   +4 more sources

Intrinsically Disordered SRC-3/AIB1 Protein Undergoes Homeostatic Nuclear Extrusion by Nuclear Budding While Ectopic Expression Induces Nucleophagy

Cells, 2019
SRC-3/AIB1 (Amplified in Breast Cancer-1) is a nuclear receptor coactivator for the estrogen receptor in breast cancer cells. It is also an intrinsically disordered protein when not engaged with transcriptional binding partners and degraded upon ...
Miguel A. Cabrita, L. Isabel Renart, Rosanna Lau, M. A. Christine Pratt   +3 more
doaj   +1 more source

Inhibition of Sp1 functions by its sequestration into PML nuclear bodies. [PDF]

PLoS ONE, 2014
Promyelocytic leukemia nuclear bodies (PML NBs) are comprised of PML and a striking variety of its associated proteins. Various cellular functions have been attributed to PML NBs, including the regulation of gene expression.
June Li, Wen-Xin Zou, Kun-Sang Chang
doaj   +1 more source

Kinetic Control of Condensate Function: How the Formation Dynamics of APBs Influence ALT Cancer Telomere Length Heterogeneity. [PDF]

Bioessays
The dynamics of PML body formation at telomeres in cancer cells using the alternative lengthening of telomeres (ALT) pathway for telomere elongation correlate with different degrees of ALT activity and might contribute to telomere length heterogeneity in ALT cancer cells.
Zhang H.
europepmc   +2 more sources

PML Nuclear Bodies [PDF]

Cold Spring Harbor Perspectives in Biology, 2010
PML nuclear bodies are matrix-associated domains that recruit an astonishing variety of seemingly unrelated proteins. Since their discovery in the early 1960s, PML bodies have fascinated cell biologists because of their beauty and their tight association with cellular disorders.
Lallemand-Breitenbach, Valérie, de Thé, H.   +1 more
openaire   +2 more sources

PML and PML-like exonucleases restrict retrotransposons in jawed vertebrates

Nucleic Acids Research, 2022
ABSTRACT We have uncovered a novel role for the promyelocytic leukemia ( PML ) gene and novel PML-like DEDDh exonucleases in the maintenance of genome stability through the restriction of LINE-1 (L1) retrotransposition in jawed vertebrates. Although the PML tumour suppressor protein
Sabateeshan Mathavarajah, Kathleen L. Vergunst, Shelby K. Williams, Raymond He, Maria Maliougina, Elias B. Habib, Mika Park, Jayme Salsman, Stéphane Roy, Ingo Braasch, Andrew J. Roger, David N. Langelaan, Graham Dellaire   +12 more
openaire   +2 more sources

Effects of arsenic on the topology and solubility of promyelocytic leukemia (PML)-nuclear bodies.

PLoS ONE, 2022
Promyelocytic leukemia (PML) proteins are involved in the pathogenesis of acute promyelocytic leukemia (APL). Trivalent arsenic (As3+) is known to cure APL by binding to cysteine residues of PML and enhance the degradation of PML-retinoic acid receptor α
Seishiro Hirano, Osamu Udagawa
doaj   +1 more source

Molecular Cloning of Alternative Splicing Variants of the Porcine PML Gene and Its Expression Patterns During Japanese Encephalitis Virus Infection

Frontiers in Veterinary Science, 2021
Promyelocytic leukemia (PML) protein is a crucial component of PML-nuclear bodies (PML-NBs). PML and PML-NBs are involved in the regulation of various cellular functions, including the antiviral immune response.
Jingjing Zhu, Zhenyu Chen, Zhenglie Dai, Xiaolong Zhou, Han Wang, Xiangchen Li, Ayong Zhao, Songbai Yang   +7 more
doaj   +1 more source

A viral ubiquitin ligase has substrate preferential SUMO targeted ubiquitin ligase activity that counteracts intrinsic antiviral defence [PDF]

, 2011
Intrinsic antiviral resistance represents the first line of intracellular defence against virus infection. During herpes simplex virus type-1 (HSV-1) infection this response can lead to the repression of viral gene expression but is counteracted by the ...
Delphine Cuchet-Lourenço, Roger D Everett, Roger D. Everett, Boutell Chris, McFarlane Steven, Cuchet, D., Mandy Glass, Steven McFarlane, Cuchet-Lourenço Delphine, Chris Boutell, Glass, M., Vanni, E., Orr Anne, Everett Roger D., McFarlane, S., Everett, R.D., Glass Mandy, Vanni Emilia, Boutell, C., Emilia Vanni, Anne Orr, Orr, A.   +21 more
core   +1 more source