Results 21 to 30 of about 100,358 (268)

Promyelocytic leukemia nuclear body-like structures can assemble in mouse oocytes

Biology Open, 2022
Promyelocytic leukemia (PML) nuclear bodies (PML-NBs), a class of membrane-less cellular organelles, participate in various biological activities. PML-NBs are known as the core-shell-type nuclear body, harboring ‘client’ proteins in their core.
Osamu Udagawa, Ayaka Kato-Udagawa, Seishiro Hirano   +2 more
doaj   +1 more source

Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy [PDF]

, 2006
Background: Progressive multifocal leukoencephalopathy (PML) was reported to have developed in three patients treated with natalizumab. We conducted an evaluation to determine whether PML had developed in any other treated patients.
Barkhof, F., Clifford, D.B., Curfman, B., Fahle, G., Fischer, S., Habil, M., Hou, J., Jäger, H.R., Major, E.O., Miszkiel, K., Mueller-Lenke, N., Radue, E.-W., Ryschkewitsch, C., Sanchez, E., Yousry, T.A.   +14 more
core   +1 more source

HSV-1 genome subnuclear positioning and associations with host-cell PML-NBs and centromeres regulate LAT locus transcription during latency in neurons. [PDF]

, 2012
Major human pathologies are caused by nuclear replicative viruses establishing life-long latent infection in their host. During latency the genomes of these viruses are intimately interacting with the cell nucleus environment.
Catez, Frédéric, Gross, Sylvain, Held, Kathrin, Labetoulle, Marc, Lomonte, Patrick, Picard, Christel, Rousseau, Antoine, Sawtell, Nancy, Theil, Diethilde   +8 more
core   +5 more sources

The still under-investigated role of cognitive deficits in PML diagnosis [PDF]

, 2017
Background: Despite cognitive deficits frequently represent the first clinical manifestations of Progressive Multifocal Leukoencephalopathy (PML) in Natalizumab-treated MS patients, the importance of cognitive deficits in PML diagnosis is still under ...
Amato, Maria Pia, Artusi, Carlo Alberto, Bandini, Fabio, Barcella, Valeria, Bertolotto, Antonio, Bresciamorra, Vincenzo, Capobianco, Marco, Capra, Ruggero, Cavaletti, Guido, Cavalla, Paola, Centonze, Diego, Clerico, Marinella, Cordioli, Cinzia, Cosottini, Mirco, D'Aleo, Giangaetano, de Riz, Marilena, De Rossi, Nicola, Deotto, Luciano, Durelli, Luca, Falcini, Mario, Ferrari, Ernesta, Fusco, Maria Luisa, Gasperini, Claudio, Gerevini, Simonetta, Ghezzi, Angelo, Grimaldi, Luigi, Guidotti, Mario, Laroni, Alice, Lugaresi, Alessandra, Mattioli, Flavia, Moiola, Lucia, Naldi, Paola, Pane, Chiara, Perrone, Patrizia, Pizzorno, Matteo, Pozzilli, Carlo, Prosperini, Luca, Rezzonico, Monica, Rovaris, Marco, Salemi, Giuseppe, Salvetti, Marco, Santuccio, Giuseppe, Scarpazza, Cristina, Scarpini, Elio, Sessa, Edoardo, Solaro, Claudio, Tabiadon, Giulia, Tortorella, Carla, Trojano, Maria, Valentino, Paola   +49 more
core   +2 more sources

Patient monitoring during treatment with natalizumab (ORP-24) [PDF]

Neurology Letters, 2023
Natalizumab (Tysabri), a recombinant humanized monoclonal antibody selective for α4- integrin, is indicated for CIS, RRMS, and active SPMS in adults.
Zohreh Abna
doaj  

The PML for rough surface scattering [PDF]

, 2008
In this paper we investigate the use of the perfectly matched layer (PML) to truncate a time harmonic rough surface scattering problem in the direction away from the scatterer.
Abramowitz, Arens, Bao, Chandler-Wilde, Chandler-Wilde, Chandler-Wilde, Chen, Chew, Collino, DeSanto, Diaz, Elschner, Jami, Kress, Lassas, Lassas, Linton, Liu, Ogilvy, Peter Monk, Saillard, Simon N. Chandler-Wilde, Voronovich, Warnick   +23 more
core   +1 more source

Intrinsically Disordered SRC-3/AIB1 Protein Undergoes Homeostatic Nuclear Extrusion by Nuclear Budding While Ectopic Expression Induces Nucleophagy

Cells, 2019
SRC-3/AIB1 (Amplified in Breast Cancer-1) is a nuclear receptor coactivator for the estrogen receptor in breast cancer cells. It is also an intrinsically disordered protein when not engaged with transcriptional binding partners and degraded upon ...
Miguel A. Cabrita, L. Isabel Renart, Rosanna Lau, M. A. Christine Pratt   +3 more
doaj   +1 more source

Inhibition of Sp1 functions by its sequestration into PML nuclear bodies. [PDF]

PLoS ONE, 2014
Promyelocytic leukemia nuclear bodies (PML NBs) are comprised of PML and a striking variety of its associated proteins. Various cellular functions have been attributed to PML NBs, including the regulation of gene expression.
June Li, Wen-Xin Zou, Kun-Sang Chang
doaj   +1 more source

Targeting the acute promyelocytic leukemia-associated fusion proteins PML/RARα and PLZF/RARα with interfering peptides [PDF]

, 2012
In acute promyelocytic leukemia (APL), hematopoietic differentiation is blocked and immature blasts accumulate in the bone marrow and blood. APL is associated with chromosomal aberrations, including t(15;17) and t(11;17).
Beez, Sabine, Demmer, Philipp, Puccetti, Elena   +2 more
core   +3 more sources

PML degradation fosters an immunosuppressive and pro-metastatic tumor microenvironment

Molecular & Cellular Oncology, 2017
The tumor suppressive functions of promyelocytic leukemia (PML) have been attributed mainly to its inhibition of various malignant properties of tumor cells.
Ya-Ting Wang, Ruey-Hwa Chen
doaj   +1 more source