Results 21 to 30 of about 42,451 (299)
Is PML a Tumor Suppressor? [PDF]
Frontiers in Oncology, 2013 The role of the promyelocytic leukemia (PML) protein has been widely tested in many different contexts, as attested by the hundreds of papers present in the literature. In most of these studies, PML is regarded as a tumor suppressor, a notion on the whole accepted by the scientific community.
M. Mazza, P.G. Pelicci
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Promyelocytic leukemia nuclear body-like structures can assemble in mouse oocytes
Biology Open, 2022 Promyelocytic leukemia (PML) nuclear bodies (PML-NBs), a class of membrane-less cellular organelles, participate in various biological activities. PML-NBs are known as the core-shell-type nuclear body, harboring ‘client’ proteins in their core.
Osamu Udagawa +2 more
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Cells, 2019 Promyelocytic leukemia (PML) bodies are dynamic intracellular structures that recruit and release a variety of different proteins in response to stress, virus infection, DNA damage and cell cycle progression. While PML bodies primarily are regarded as nuclear compartments, they are forced to travel to the cytoplasm each time a cell divides, due to ...
Anna Lång, Emma Lång, Stig Ove Bøe
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Viscoelastic modeling and factor Q for reflection data
Geofísica Internacional, 2012 Los modelos numéricos viscoelásticos, basados en el concepto de mecanismos de dispersión, toman en cuenta las variables de memoria y algunos parámetros de dispersión, a saber los tiempos de relajación de tensión. En la práctica de la geofísica, el factor
Vladimir Sabinin
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Perspectives in PML: a unifying framework for PML function
Frontiers in Bioscience, 2009 The promyeloctyic leukemia protein (PML) has established activities as a potent repressor of proliferation, and oncogenic transformation, a promoter of apoptosis, an inducer of senescence, and may act as an inhibitor of angiogenesis in mammalian systems. Loss of PML or its nuclear bodies is associated with many human disease states.
Katherine L B, Borden +1 more
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Patient monitoring during treatment with natalizumab (ORP-24) [PDF]
Neurology Letters, 2023 Natalizumab (Tysabri), a recombinant humanized monoclonal antibody selective for α4- integrin, is indicated for CIS, RRMS, and active SPMS in adults.
Zohreh Abna
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SUMO pathway dependent recruitment of cellular repressors to herpes simplex virus type 1 genomes [PDF]
, 2011 Components of promyelocytic leukaemia (PML) nuclear bodies (ND10) are recruited to sites associated with herpes simplex virus type 1 (HSV-1) genomes soon after they enter the nucleus. This cellular response is linked to intrinsic antiviral resistance and
Delphine Cuchet-Lourenço +24 more
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Cells, 2019 SRC-3/AIB1 (Amplified in Breast Cancer-1) is a nuclear receptor coactivator for the estrogen receptor in breast cancer cells. It is also an intrinsically disordered protein when not engaged with transcriptional binding partners and degraded upon ...
Miguel A. Cabrita +3 more
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A Collaborative Approach to Addressing PML: The PML Consortium [PDF]
Journal of Multiple Sclerosis, 2013 Progressive multifocal leukoencephalopathy (PML) is a rare but severe and often fatal disease of the central nervous system most commonly associated with severe immunodeficiency. PML occurs in many clinical conditions as shown in the table below (Table 1) [1-23]. The greatest number of PML cases occurs as a sequel to HIV infection.
William O. Iverson +2 more
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Inhibition of Sp1 functions by its sequestration into PML nuclear bodies. [PDF]
PLoS ONE, 2014 Promyelocytic leukemia nuclear bodies (PML NBs) are comprised of PML and a striking variety of its associated proteins. Various cellular functions have been attributed to PML NBs, including the regulation of gene expression.
June Li, Wen-Xin Zou, Kun-Sang Chang
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