Results 251 to 260 of about 42,451 (299)
ZEB1 Promotes Alternate Lengthening of Telomeres at Multiple Levels. [PDF]
Genetta TL +5 more
europepmc +1 more source
Plenary Abstracts Session & Oral Presentations
HemaSphere, Volume 10, Issue S1, June 2026.
wiley +1 more source
PML and PML nuclear bodies: Implications in antiviral defence
The establishment of an intracellular antiviral state is the defining activity of interferons (IFNs) as well as the property that permitted their discovery. Several pathways have been implicated in resistance to viral infection in IFN-treated cells, one of which implicates the ProMyelocytic Leukaemia (PML) protein and PML nuclear bodies (NBs, also ...
Everett, Roger, Chelbi-Alix, Mounira
openaire +4 more sources
Role of cytoplasmic forms of PML and PML-RARα in the response to therapy
The PML tumour suppressor of acute promyelocytic leukaemia (APL) regulates major apoptotic and growth suppressive pathways. In APL, one PML allele is involved in a chromosomal translocation generating the PML-RARα fusion protein. Two missense mutations in the remaining PML allele have been identified, which give rise to a truncated cytoplasmic PML ...
Bellodi C +7 more
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Controlling senescence by PML and PML nuclear bodies
Cellular senescence is a stress response wherein proliferating competent cells undergo a stable cell cycle arrest in response to a variety of intrinsic and extrinsic stimuli, including telomere shortening, oxidative stress, DNA damage or the constitutive activation of oncogenes among others. All these stimuli have in common the potential to initiate or
Acevedo Aquino, Mariana de la Cruz
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PML isoforms: a molecular basis for PML pleiotropic functions
Trends in Biochemical Sciences, 2022PML is a stress-responsive protein that coordinates assembly of phase-separated nuclear aggregates, known as PML nuclear bodies (PML-NBs), where a large number of protein interactors and chromatin processes are finely regulated. Tampering with the PML gene produces a variety of phenotypic consequences that include promoting or interfering with tumor ...
Martina Uggè +3 more
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Regulation of NF-κB by PML and PML-RARα
The transcription factor NF-κB is the master regulator of the immune response but also acts broadly to regulate gene expression that influences cell survival, proliferation and differentiation. Post-translational modification of NF-κB, phosphorylation in particular, is essential for the transactivation activity of NF-κB. Promyelocytic Leukemia (PML) is
Ahmed, Abrar
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