Results 101 to 110 of about 19,899 (215)

CRISPR‐based therapeutic and modelling approaches in Huntington's disease: Progress, challenges and future directions

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Clustered regularly interspaced short palindromic repeat (CRISPR) is transforming Huntington's disease research through allele‐selective huntingtin (HTT) targeting, transcriptional and RNA suppression, and advanced disease modelling. Progress towards precision therapy depends on safe central nervous system (CNS) delivery, reduced off‐target and immune ...
Kairat Zhakipbekov, Surayyo Eshkabilova, Zokir Raximov, Sharof Eshonov, Abdusaid Khasanov, Ziyodulla Tokhtamurod, Axmadjan Ashurmetov, Avazbek Abduraxmanov, Niyozbek Abdurakhmonov, Elmurod Eshqobilov, Seyed Mohsen Mirhosseini, Amir Arsalan Ghahari   +11 more
wiley   +1 more source

Endonuclease activity of PMS2.

, 2023
The endonuclease activity of PMS was measured in vitro using nuclear extracts from p53ko/ko;Cdk2ko/ko, p53ko/ko, Pms2ko/ko, and wild type (WT) MEFs.
Kajal Biswas (14833686), Nathan Palmer (264897), Philipp Kaldis (3122793), S. Zakiah A. Talib (9536989), Christine M. F. Goh (9536992), Shyam K. Sharan (3142788)   +5 more
core   +1 more source

Estradiol Promotes Tumor Progression in ERα‐Low Endometrial Cancer via the GPER/SphK1 Pathway

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
Estradiol (E2) promotes tumor progression in ERα‐low endometrial cancer through the GPER/SphK1/ERK1/2 signaling axis. E2 binding to GPER activates SphK1 and downstream ERK1/2, upregulating Cyclin D1, Cyclin E1, and MMP‐9 to drive cell proliferation, migration, and invasion.
Xiuwen Wang, Haofei Sun, Xin Wen, Weiwei Xin, Zhandong Hu, Zhongwei Zhao, Lizhi Zhang   +6 more
wiley   +1 more source

Absence of Pms2 increases somatic expansion load of the (GAA·TTC)_n sequence in cerebrum.

, 2013
Analysis of instability in cerebrum of Pms2+/+ and Pms2−/− mice. Representative autoradiographs from (A) Pms2+/+ and (B) Pms2−/− cerebrum are shown. Progenitor allele lengths of 229, 194, 135, and 94 repeats for Pms2+/+ and 229, 185, 130, and 86 repeats ...
Ricardo Mouro Pinto (207712), Chiranjeevi Sandi (283956), Mark A. Pook (126056), Sanjay I. Bidichandani (22466), Rebecka L. Bourn (303235), Irene De Biase (22465), Sahar Al-Mahdawi (126054)   +6 more
core   +1 more source

PMS2 mutation spectra in Norway and risk of cancer for carriers of pathogenic variants

Hereditary Cancer in Clinical Practice
Background In Norway, we have offered testing of PMS2 since 2006, and have a large national cohort of carriers. The aim of this study was to describe all PMS2 variants identified, and to describe frequency, spectrum and penetrance of cancers in carriers ...
Wenche Sjursen, Hanne K. Hyldebrandt, Liss Anne S. Lavik, Bjørn Ivar Haukanes, Sarah Ariansen, Siri Briskemyr, Anna E. Sylvander, Marianne T. Haavind, Maren F. Olsen, Elin S. Røyset, Hildegunn Vetti, Astrid Stormorken, Eli Marie Grindedal   +12 more
doaj   +1 more source

Automatic Conversion of NICE Guidelines to an Executable Computational Model Using Large Language Models

Learning Health Systems, Volume 10, Issue 4, October 2026.
ABSTRACT Introduction The UK National Institute for Health and Care Excellence (NICE) produce guidelines that provide evidence‐based recommendations to support clinical care across England and Wales, but remain available in unstructured natural language form.
Ashvin Gupta, Denys Prociuk, Alessandra Russo, Brendan C. Delaney   +3 more
wiley   +1 more source

Cooccurrence of Homologous Recombination Deficiency and Mismatch Repair Deficiency in Colorectal Cancer

MedComm, Volume 7, Issue 10, October 2026.
Cooccurrence of dMMR and HRD in colorectal cancer. On the left blue shaded area, the dMMR (deficient mismatch repair) pathway is shown as a result of the loss of key DNA repair genes MLH1, MSH2, MSH6, and PMS2, which cause single strand breaks.
Xu Zhang, Hao Xu, Kailai Wang, Wangxiong Hu   +3 more
wiley   +1 more source

MSH6 and PMS2 expression in colorectal carcinoma

Bioinformation
Microsatellite instability (MSI) is a key feature in colorectal carcinomas (CRCs), but its role in diagnosis and prognosis, particularly through immunohistochemical markers like MSH6 and PMS2, remains underexplored. Conducted at Sree Balaji Medical College and Hospital, 50 histologically confirmed CRC samples were analyzed.
M, Safin, S, Marylilly, MS, Janhavi
openaire   +2 more sources

Immunohistochemical Expression of MutS Homolog 6 (MSH6) and Postmeiotic Segregation 2 (PMS2) and Their Association with Clinicopathological Features in Colorectal Carcinoma: A Cross-sectional Study [PDF]

National Journal of Laboratory Medicine
Introduction: Colorectal Carcinoma (CRC) is a gastrointestinal malignancy arising from colon or rectum. Adenocarcinoma is the most common type of CRC. It is one of the most commonly diagnosed cancer worldwide, ranking third only to lung cancer and female
Jasmine Kaur, Manas Madan, Manisha Sharma, Karamjit Gill, Shahaan Sharma   +4 more
doaj   +1 more source

The ‘Prostate Cancer Screening for People at Genetic Risk of Aggressive Disease’ (PATROL) study

BJU International, Volume 138, Issue 4, Page 600-606, October 2026.
Background Inherited (germline) pathogenic and likely pathogenic variants (gPVs) in key genes associated with increased risk of prostate cancer (PCa) now warrant more attentive PCa screening per National Comprehensive Cancer Network (NCCN) guidelines—e.g., BRCA2, HOXB13, ATM, BRCA1, MSH2, MSH6, CHEK2 and TP53.
Heather H. Cheng, Kara N. Maxwell, Keyan Salari, Matthew R. Cooperberg, Kristin Follmer, Joanne M. Jeter, Grace Jun, Daniel J. Lee, Hiten D. Patel, Edward M. Schaeffer, Alexandra O. Sokolova, Erika M. Wolff, Daniel W. Lin   +12 more
wiley   +1 more source