Results 121 to 130 of about 19,899 (215)
Hereditary Cancer in Clinical PracticeBackground While numerous studies have demonstrated variations in colorectal cancer (CRC) incidence among Lynch Syndrome (LS)-associated germline pathogenic variant (gPV) carriers, limited data are available regarding tailoring surveillance and treatment
Romy N Kuipers +5 more
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PMS2 and its role in mismatch repair deficiency syndrome
, 2011 The PMS2 protein IS a component of the post-replicative DNA mismatch repair (MMR) system, which acts to correct mispaired nucleotides and small insertion-deletion loops in new DNA duplexes.
Ingham, Danielle
core
Optimizing of protocols regarding immunohistochemic detection of mismatch repair-proteins
Bioingeniøren, 2019 Background: Immunohistochemical staining can be used to detect mismatch repair proteins such as MLH1, PMS2, MSH2 and MSH6. These proteins are normally expressed in the cell nucleus.
Eirin Amundlien +2 more
doaj
Lynch syndrome with MLH1 germline variant in an extended family: a case report
Open Life SciencesLynch syndrome (LS) is an inherited cancer predisposition syndrome associated with an increased risk of several malignancies, particularly colorectal cancer (CRC). The diagnosis of LS is typically based on family history and confirmed by genetic testing,
Duan Zhipei +4 more
doaj +1 more source