Results 91 to 100 of about 6,468 (198)
Inorganic Metal Nanoparticles in Reproductive Biology: Applications, Toxicities and Future Prospects
ChemPlusChem, Volume 90, Issue 5, May 2025.Metal nanoparticles (MNPs) have shown great promise in the livestock industry such as semen collection, nano‐purification, cryopreservation, sex sorting, bioimaging, drug and gene delivery. However, reproductive toxicity induced by MNP has adverse effects on various sexual functions including poor sperm parameters, testicular damage, ovary injury, and ...
Sangita Kundu +3 more
wiley +1 more source
Exploring of pyrazinamidase recombinant activity from PZA-sensitive and resistant Mycobacterium tuberculosis expressed in Escherichia coli BL21 (DE3) [PDF]
Brazilian Journal of BiologyThe mutations of pncA gene encoding pyrazinamidase/PZase in Mycobacterium tuberculosis are often associated with pyrazinamide/PZA resistance. The H and R1 isolates showed significant phenotypic differences to PZA.
P. Purkan +9 more
doaj +1 more source
BMC Infectious Diseases, 2020 Background Pyrazinamide still may be a useful drug for treatment of rifampin-resistant (RR-TB) or multidrug-resistant tuberculosis (MDR-TB) in China while awaiting scale up of new drugs and regimens including bedaquiline and linezolid.
Hui Xia +6 more
doaj +1 more source
Activation and inhibition of sirtuins: From bench to bedside
Medicinal Research Reviews, Volume 45, Issue 2, Page 484-560, March 2025.Abstract The sirtuin family comprises seven NAD+‐dependent enzymes which catalyze protein lysine deacylation and mono ADP‐ribosylation. Sirtuins act as central regulators of genomic stability and gene expression and control key processes, including energetic metabolism, cell cycle, differentiation, apoptosis, and aging.
Francesco Fiorentino +3 more
wiley +1 more source
Christian v R (No 2) [2006] PNCA 1 (2 March 2006) [PDF]
, 2012 Judgement of the Court of Appeals, as posted on the Pacific Islands Legal Institute (PacLII ...
Court of Appeal of the Pitcairn Islands
core
Resistance related metabolic pathways for drug target identification in Mycobacterium tuberculosis [PDF]
, 2016 Criteria used to filter high priority M.tuberculosis drug targets. The genes highlighted in bold satisfied all the selection criteria. The hyphen (â) indicates exclusion from further analysis.
Alan Christoffels +4 more
core +8 more sources
CNS Neuroscience &Therapeutics, Volume 31, Issue 3, March 2025.The article unraveled that preventive administration of DNLA may delay the impairment of learning and memory in APP/PS1 mice. The molecular mechanism may be related to promoting the mTOR‐TFEB‐v‐ATPase pathway. ABSTRACT Introduction Alzheimer's disease (AD) is a progressive neurodegenerative disorder with cognitive impairment that currently is incurable.
Yajuan Wu +6 more
wiley +1 more source
BMC Infectious Diseases, 2017 Background Pyrazinamide (PZA) plays a unique role in the treatment for multidrug-resistant tuberculosis (MDR-TB) in both first- and second-line regimens.
Yu Pang +6 more
doaj +1 more source
Land use/cover changes in the municipality of Elx (1956-2005) [PDF]
, 1997 23 páginas, 3 figuras, 3 cuadros.[ES] El objetivo principal de este artículo es analizar la dinámica espacial y temporal de los usos y coberturas del suelo entre 1956 y 2005 en Elx (Alicante).
Antonio Valera Lozano +17 more
core +2 more sources
Advanced Science, Volume 12, Issue 5, February 3, 2025.A common insertion variant exhibits cis‐regulation potential for the m6A eraser ALKBH5, which demethylates FBXL5 mRNA, leading to reduction in reactive oxygen species levels, inhibition of PI3K/AKT and NF‐kB pathways, and consequent suppression of NSCLC cells.
Lei Cheng +11 more
wiley +1 more source