Results 11 to 20 of about 7,584 (199)

Membrane Perforation by the Pore-Forming Toxin Pneumolysin [PDF]

Biophysical Journal, 2020
Significance Pneumolysin, a pore-forming toxin of Streptococcus pneumoniae , assembles into rings on cholesterol-containing membranes of host cells. β -hairpins form a barrel-shaped transmembrane
Martin Vögele, Ramachandra M. Bhaskara, Estefania Mulvihill, Katharina van Pee, Özkan Yıldız, Werner Kühlbrandt, Daniel J. Müller, Gerhard Hummer   +7 more
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Physical Behavior of Pneumolysin [PDF]

Journal of Bacteriology, 1969
Pneumolysin behaved as an acidic protein having an isoelectricpH of 4.9, a molecular weight of approximately 63,000, and a sedimentation coefficient of approximately 4.3.
Arnold S. Kreger, Alan W. Bernheimer
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Anticytotoxin Effects of Amentoflavone to Pneumolysin

Biological & Pharmaceutical Bulletin, 2016
Pneumolysin (PLY) is a devastating bacterial protein toxin of Streptococcus pneumoniae that punctures the cytomembrane, leading to pathological reactions, such as cell disruption and inflammation. Drugs capable of closely impacting the toxin are considered advantageous in the treatment of bacterial infections.
Xiaoran Zhao, Bowen Liu, Shui Liu, Lin Wang, Jianfeng Wang   +4 more
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Pneumolysin: Pathogenesis and Therapeutic Target [PDF]

Frontiers in Microbiology, 2020
Streptococcus pneumoniae is an opportunistic pathogen responsible for widespread illness and is a major global health issue for children, the elderly, and the immunocompromised population. Pneumolysin (PLY) is a cholesterol-dependent cytolysin (CDC) and key pneumococcal virulence factor involved in all phases of pneumococcal disease, including ...
Andrew T. Nishimoto, Jason W. Rosch, Elaine I. Tuomanen   +2 more
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Purification of Pneumolysin [PDF]

Infection and Immunity, 1971
A procedure for the purification of pneumolysin has been developed. Its use results in a 96-fold increase in specific activity from the original crude pneumococcal extract to the final purified product. The purified material is heat-labile and is inactivated by trypsin and cholesterol; inactivation by p ...
C N, Shumway, S J, Klebanoff
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Viability and Virulence of Pneumolysin, Pneumococcal Surface Protein A, and Pneumolysin/Pneumococcal Surface Protein A Mutants in the Ear [PDF]

JAMA Otolaryngology–Head & Neck Surgery, 2013
Understanding how pneumococcal proteins affect the pathology of the middle ear and inner ear is important for the development of new approaches to prevent otitis media and its complications.To determine the viability and virulence of Streptococcus pneumoniae mutants deficient in pneumolysin (Ply-) and pneumococcal surface protein A (PspA-) in the ...
Patricia A. Schachern, Vladimir Tsuprun, Sarah Goetz, Sebahattin Cüreoǧlu, Steven K. Juhn, David E. Briles, Michael M. Paparella, Patricia Ferrieri   +7 more
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Pneumolysin Causes Neuronal Cell Death through Mitochondrial Damage [PDF]

Infection and Immunity, 2007
ABSTRACT Bacterial toxins such as pneumolysin are key mediators of cytotoxicity in infections. Pneumolysin is a pore-forming toxin released by Streptococcus pneumoniae , the major cause of bacterial meningitis.
Johann Braun, Olaf Hoffmann, Miriam Schickhaus, Dorette Freyer, Emilie Dagand, Daniela Bermpohl, Timothy J. Mitchell, Ingo Bechmann, Joerg R. Weber   +8 more
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Infectious Triggers and Immune Dynamics in Guillain-Barré Syndrome: Revisiting Campylobacter jejuni and the Silent Role of Haemophilus influenzae. [PDF]

Microbiologyopen
Schematic representation of the gut‐brain axis and microbial triggers in Guillain–Barré Syndrome. Post‐infectious immune responses, particularly through molecular mimicry by pathogens, such as Campylobacter jejuni and Haemophilus influenzae, lead to demyelination and subsequent neuromuscular paralysis.
Ramesh A, Subbarayan R, Srinivasan D, Balakrishnan R, Shrestha R, Chauhan A.   +5 more
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Inhibition of Pneumolysin Cytotoxicity by Hydrolyzable Tannins [PDF]

Antibiotics, 2020
Streptococcus pneumoniae causes invasive infections such as otitis media, pneumonia and meningitis. It produces pneumolysin (Ply) toxin, which forms a pore to host cell membrane and has multiple functions in S. pneumoniae pathogenesis. The Ply C-terminal domain 4 mediates binding to membrane cholesterol and induces the formation of pores composed of up
Santeri Maatsola, Sami T. Kurkinen, Marica T. Engström, Thomas K.M. Nyholm, Olli T. Pentikäinen, Juha‐Pekka Salminen, Sauli Haataja   +6 more
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Adenosine Triphosphate Neutralizes Pneumolysin-Induced Neutrophil Activation [PDF]

The Journal of Infectious Diseases, 2020
Abstract Background In tissue infections, adenosine triphosphate (ATP) is released into extracellular space and contributes to purinergic chemotaxis. Neutrophils are important players in bacterial clearance and are recruited to the site of tissue infections.
Cuypers, Fabian, Klabunde, Björn, Gesell Salazar, Manuela, Surabhi, Surabhi, Skorka, Sebastian B, Burchhardt, Gerhard, Michalik, Stephan, Thiele, Thomas, Rohde, Manfred, Völker, Uwe, Hammerschmidt, Sven, Siemens, Nikolai   +11 more
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