Results 31 to 40 of about 7,584 (199)

Proinflammatory Interactions of Pneumolysin with Human Neutrophils [PDF]

The Journal of Infectious Diseases, 2001
The effects of pneumolysin on the proinflammatory activity of human neutrophils, as well as on cation fluxes in these cells, have been investigated. Superoxide production, release of elastase, CR3 expression, phospholipase A2 activity, and alterations in membrane potential were measured by use of lucigenin-enhanced chemiluminescence and colorimetric ...
R, Cockeran, A J, Theron, H C, Steel, N M, Matlola, T J, Mitchell, C, Feldman, R, Anderson   +6 more
openaire   +2 more sources

Human Genetic GLUT1 Deficiency Results in Impaired T Cellular IFN-γ Production. [PDF]

Eur J Immunol
GLUT1 deficiency prevents glucose uptake in T cells resulting in lower intracellular ATP generation and IFNy production.
Jong R, Rajendiran A, Hriczko JT, Subramanyam SH, Rein A, Häusler M, Orlikowsky T, Wagner N, Erny D, Ohl K, Tenbrock K.   +10 more
europepmc   +2 more sources

Export Requirements of Pneumolysin in Streptococcus pneumoniae [PDF]

Journal of Bacteriology, 2012
ABSTRACT Streptococcus pneumoniae is a major causative agent of otitis media, pneumonia, bacteremia, and meningitis. Pneumolysin (Ply), a member of the cholesterol-dependent cytolysins (CDCs), is produced by virtually all clinical isolates of S.
Katherine E, Price, Neil G, Greene, Andrew, Camilli   +2 more
openaire   +2 more sources

Clinical Streptococcus pneumoniae isolates induce differing CXCL8 responses from human nasopharyngeal epithelial cells which are reduced by liposomes [PDF]

, 2016
BACKGROUND: Streptococcus pneumoniae causes several human diseases, including pneumonia and meningitis, in which pathology is associated with an excessive inflammatory response.
Annette Draeger, Denis Grandgirard, Denja Baumgartner, Eduard Babiychuk, Lucy J. Hathaway, Stephen L. Leib, Suzanne Aebi   +6 more
core   +1 more source

Measuring kinetic drivers of pneumolysin pore structure [PDF]

European Biophysics Journal, 2016
Most membrane attack complex-perforin/cholesterol-dependent cytolysin (MACPF/CDC) proteins are thought to form pores in target membranes by assembling into pre-pore oligomers before undergoing a pre-pore to pore transition. Assembly during pore formation is into both full rings of subunits and incomplete rings (arcs).
Gilbert, RJC, Sonnen, AFP
openaire   +3 more sources

Macrocyclic Peptide Probes for Immunomodulatory Protein CD59: Potent Modulators of Bacterial Toxin Activity and Antibody‐Dependent Cytotoxicity

Angewandte Chemie, Volume 137, Issue 27, July 1, 2025.
This study presents novel macrocyclic peptides with low nanomolar affinity for CD59, an immunomodulatory cell surface receptor associated with human disease. Crystallographic and structure‐activity relationship (SAR) studies reveal peptide CP‐06 mimics the binding of biologically relevant CD59 interaction partners. Dimeric and lipidated CP‐06 analogues
Jasmine K. Bickel, Ammar. I. S. Ahmed, Aidan B. Pidd, Rhodri M. Morgan, Tom E. McAllister, Sam Horrell, Emma C. Couves, Hemavathi Nagaraj, Edward J. Bartlett, Kamel El Omari, Akane Kawamura, Doryen Bubeck, Edward W. Tate   +12 more
wiley   +2 more sources

Polyvalent Immunoglobulin Preparations Inhibit Pneumolysin-Induced Platelet Destruction

Thrombosis and Haemostasis, 2021
Platelets play an important role in the development and progression of respiratory distress. Functional platelets are known to seal inflammatory endothelial gaps and loss of platelet function has been shown to result in loss of integrity of pulmonary vessels.
Friederike Wiebe, Stefan Handtke, Jan Wesche, Annabel Schnarre, Raghavendra Palankar, Martina Wolff, Kristin Jahn, Franziska Voß, Sabrina Weißmüller, Jörg Schüttrumpf, Andreas Greinacher, Sven Hammerschmidt   +11 more
openaire   +2 more sources

Pneumolysin-Induced Complement Depletion during Experimental Pneumococcal Bacteremia [PDF]

Infection and Immunity, 2001
ABSTRACT To quantify complement depletion by pneumolysin during Streptococcus pneumoniae bacteremia, cirrhotic and control rats were infected intravenously with one of three isogenic mutant strains of S. pneumoniae expressing different forms of pneumolysin. Outcome measures included
R B, Alcantara, L C, Preheim, M J, Gentry-Nielsen   +2 more
openaire   +2 more sources

Pneumolysin Activates Macrophage Lysosomal Membrane Permeabilization and Executes Apoptosis by Distinct Mechanisms without Membrane Pore Formation [PDF]

, 2014
Intracellular killing of Streptococcus pneumoniae is complemented by induction of macrophage apoptosis. Here, we show that the toxin pneumolysin (PLY) contributes both to lysosomal/phagolysosomal membrane permeabilization (LMP), an upstream event ...
Albiger, Ali, Alouf, Baba, Berry, Beurg, Bewley, Bewley, Bidère, Bouvier, Braun, Braun, Brown, Brueggemann, Canvin, Clark, Cockeran, Craven, Daigneault, Dela Cruz, Dockrell, Dockrell, Fang, Gilbert, Gillespie, Gordon, Harder, Hornung, Houldsworth, Ip, Jefferies, Johansson, Kadioglu, Kadioglu, Kagan, Kemp, Kirkham, Knapp, Knapp, Koga, Kurz, Littmann, Madden, Malley, Marriott, Marriott, Marriott, McComb, McNeela, Meixenberger, Mitchell, Mitchell, Montgomery, Muñoz-Planillo, Opitz, Ortqvist, Qi, Rajput, Ratner, Rossjohn, Rubins, Sabroe, Schmeck, Schmeck, Srivastava, Talstad, Thiele, Tilley, Turk, Uchimoto, Witsell, Witzenrath, Yuste   +72 more
core   +2 more sources

Repeat Intraocular Sampling and Microbiological Testing in Infectious Endophthalmitis: A 27‐Year Prospective Observational Study at an Australian Statewide Tertiary Referral Centre

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background Endophthalmitis requiring multiple ocular tissue sampling for microbiological testing is uncommon and has not been previously studied. This study aims to analyse cases with at least two ocular tissue samplings and testing of different ocular samples against culture yields. Methods A 27‐year prospective observational study using data
Pravena Kumaran, Maedbh Rhatigan, Zelia Chiu, Jasmine Lichtenstein, Penelope J. Allen, Rosie C. H. Dawkins   +5 more
wiley   +1 more source