Results 41 to 50 of about 7,584 (199)

Comparative Genomic Analysis and In Vivo Modeling of Streptococcus pneumoniae ST3081 and ST618 Isolates Reveal Key Genetic and Phenotypic Differences Contributing to Clonal Replacement of Serotype 1 in The Gambia [PDF]

, 2017
Streptococcus pneumoniae serotype 1 is one of the leading causes of invasive pneumococcal disease (IPD) in West Africa, with ST618 being the dominant cause of IPD in The Gambia.
Abdullahi, Adegbola, Alexander, Antonio, Antonio, Aras Kadioglu, Bentley, Berry, Boetzer, Brenda Kwambana-Adams, Brendan W Wren, Brueggemann, Brueggemann, Burghout, Calix, Calix, Chinelo Ebruke, Chiou, Chrispin Chaguza, Cock, Cornick, Croucher, de Steenhuijsen Piters, Dean Everett, Duarte, Ebruke, Gessner, Grant Mackenzie, Hausdorff, Henriques-Normark, Hill, Holliman, Isaacman, Jennifer Cornick, Jin, Jourdain, Kadioglu, Kadioglu, Kirkham, Kwambana-Adams, Laura Bricio-Moreno, Leimkugel, Marie Yang, Martin Antonio, McNeela, Miles, Neill, Nunes, Oliver, Park, Park, Richards, Rubins, Spratt, Spratt, Stamatakis, Staples, Tamura, Yaro, Zerbino   +59 more
core   +2 more sources

Structural and functional analogy between pneumolysin and proaerolysin [PDF]

Protein Engineering Design and Selection, 1997
Pneumolysin and proaerolysin are bacterial toxins that form pores in host cells by oligomerization. We propose that they may have similar structures despite a poor sequence identity. The crystal structure of proaerolysin reveals a protein composed of four domains, arranged in the shape of an elongated comma.
Sowdhamini, R, Mitchell, TJ, Andrew, PW, Morgan, PJ   +3 more
openaire   +3 more sources

Two Sides of the Same Coin—Mechanistic Insight, Diagnostic Application and Therapeutic Translation of Bacterial and Host‐Derived Extracellular Vesicles

Journal of Extracellular Biology, Volume 4, Issue 11, November 2025.
ABSTRACT Extracellular vesicles (EVs) have gained increasing attention in recent years due to their pivotal role in both health and disease. Emerging from both eukaryotic and prokaryotic cells, EVs serve as essential mediators of intercellular communication, exceeding the simplistic interactions observed with individual molecules. In this comprehensive
Philipp Arnold, Fanni Annamária Boros, Jochen Mattner, Gerald Seidel, Chaofan Liu, Inga Viktoria Hensel, Jan Van Deun, Raphael Schwendner, Janina Müller‐Deile, Nina Sopel, Andreas Ramming, Mario R. Angeli, Simon Rauber, Cláudia Vilhena, Andreas Baur, Stefan Wirtz, Klaus Überla, Heiko Reutter, Linda‐Marie Mulzer, Alina C. Hilger, Friederike Zunke, Wei Xiang, Gregor Fuhrmann, Claudia Günther   +23 more
wiley   +1 more source

Streptococcus Pneumoniae Secretes Hydrogen Peroxide Leading to DNA Damage and Apoptosis in Lung Cells [PDF]

, 2014
Streptococcus pneumoniae is a leading cause of pneumonia and one of the most common causes of death globally. The impact of S. pneumoniae on host molecular processes that lead to detrimental pulmonary consequences is not fully understood.
Ackerman, Shelley, Chow, Vincent T., Engelward, Bevin P., He, Fang, Kwang, Jimmy, Li, Na, Parrish, Marcus Curtis, Rai, Prashant, Tay, Ian Jun Jie, Tay, Jun Jie Ian   +9 more
core   +1 more source

Crystal structure and biophysical characterisation of the enterococcal foldase PpiC, a cross‐opsonic antigen against gram‐positive nosocomial pathogens

The FEBS Journal, Volume 292, Issue 20, Page 5475-5490, October 2025.
PpiC is an enterococcal lipoprotein endowed with both Peptidyl‐prolyl cis‐trans isomerase (PPIase) and foldase activities. It is a potential target for novel antimicrobials and a promising vaccine antigen. We determined the crystal structure of the enzyme, showing that PpiC adopts a dimeric organisation embedding two catalytic parvulin‐type PPIase ...
Valeria Napolitano, Eliza Kramarska, Ornella Ghilardi, Felipe Romero‐Saavedra, Pompea Del Vecchio, Flavia Squeglia, Johannes Huebner, Rita Berisio   +7 more
wiley   +1 more source

Systematic Review on the Role of Microfluidic Platforms in Advancing Scalable and Precise Microbial Bioprocessing

Engineering in Life Sciences, Volume 25, Issue 9, September 2025.
ABSTRACT Microbial bioprocessing is a key technology for the production of a wide range of biomolecules, including proteins, enzymes, antibiotics, and other bioactive compounds. In recent years, there has been an increasing interest in using microfluidic platforms for bioprocessing, due to the ability to precisely control and manipulate fluids at the ...
Alperen Alpural, Ilgin Kimiz‐Gebologlu, Mayur Parekh, Esra Imamoglu, Zulfiqur Ali, Ozlem Yesil‐Celiktas   +5 more
wiley   +1 more source

Stepwise visualization of membrane pore formation by suilysin, a bacterial cholesterol-dependent cytolysin [PDF]

, 2014
Membrane attack complex/perforin/cholesterol-dependent cytolysin (MACPF/CDC) proteins constitute a major superfamily of pore-forming proteins that act as bacterial virulence factors and effectors in immune defence.
Baker, Bourdeau, Connell, Czajkowsky, Dang, Frank, Goddard, Hope, Hotze, Hotze, Hotze, Johnson, Krivov, Köster, Laemmli, Leung, Lindahl, Liu, Ludtke, Lukoyanova, Malhotra, Marchioretto, Mikhaylov, Mindell, Murzin, Nakamura, Owen, Pettersen, Ramachandran, Ramachandran, Reboul, Reboul, Rosado, Rossjohn, Sali, Sato, Shatursky, Shen, Shepard, Sonnen, Tilley, van Heel, Xu   +42 more
core   +3 more sources

Polyhydroxyalkanoate beads as a particulate vaccine against Streptococcus pneumoniae and Neisseria meningitidis : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Microbiology at Massey University, Manawatu, New Zealand [PDF]

, 2017
Listed in 2018 Dean's List of Exceptional ThesesStreptococcus pneumoniae and Neisseria meningitidis are the major causes of pneumonia and meningitis, respectively, worldwide.
González Miró, Majela
core  

Pneumococcal Pneumolysin Induces DNA Damage and Cell Cycle Arrest [PDF]

, 2015
Streptococcus pneumoniae produces pneumolysin toxin as a key virulence factor against host cells. Pneumolysin is a cholesterol-dependent cytolysin (CDC) toxin that forms lytic pores in host membranes and mediates pneumococcal disease pathogenesis by ...
Chow, Vincent H., Engelward, Bevin P, He, Fang, 1956-, Kwang, Jimmy, Rai, Prashant   +4 more
core   +1 more source

Antibody responses to nasopharyngeal carriage of Streptococcus pneumoniae in adults: A longitudinal household study [PDF]

, 2005
Background. Natural immunity to Streptococcus pneumoniae is thought to be induced by exposure to S. pneumoniae or cross-reactive antigens. No longitudinal studies of carriage of and immune responses to S.
Andrews, N, Ashton, L, Edmunds, J, Gay, N, George, R, Goldblatt, D, Hussain, M, Kayhty, H, Melegaro, A, Miller, E, Pebody, R, Soininen, A, Virta, C   +12 more
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