Results 51 to 60 of about 7,584 (199)

Citrus Flavonoids as Antimicrobials

Chemistry &Biodiversity, Volume 22, Issue 6, June 2025.
Citrus flavonoids are powerful and versatile antimicrobials whose mechanism of action often involves disruption of the bacterial membrane, thereby minimizing antimicrobial resistance. This study provides a unified perspective. ABSTRACT Citrus flavonoids are highly bioactive compounds exerting numerous health benefits including anticancer, antioxidant ...
Rosaria Ciriminna, Giovanna Li Petri, Giuseppe Angellotti, Rafael Luque, Anne‐Sylvie Fabiano Tixier, Francesco Meneguzzo, Mario Pagliaro   +6 more
wiley   +1 more source

The membrane attack complex, perforin and cholesterol-dependent cytolysin superfamily of pore-forming proteins [PDF]

, 2016
The membrane attack complex and perforin proteins (MACPFs) and bacterial cholesterol-dependent cytolysins (CDCs) are two branches of a large and diverse superfamily of pore-forming proteins that function in immunity and pathogenesis.
Blackman, Bubeck, Bubeck, Cascales, Collier, Czajkowsky, Degiacomi, Dudkina, Dunstone, Estévez-Calvar, Ghatak, Giddings, Gilbert, Gilbert, Gilbert, Gilbert, Giousoh, Hadders, Hadders, Heuck, Hirst, Hotze, Hotze, Hotze, Housden, Jiang, Johnson, Johnson, Kawano, Kondos, LaChapelle, Law, Leka, Leung, Lovelace, Lukoyanova, Marchioretto, McCormack, Menestrina, Merle, Metkar, Morgan, Morgan, Mulvihill, Ounjai, Pardo-López, Peraro, Podack, Podobnik, Popoff, Praper, Ramachandran, Ramachandran, Ramm, Reboul, Reboul, Rosado, Rosado, Rossjohn, Sato, Serna, Seveau, Shatursky, Shepard, Shewell, Sonnen, Sugawara, Taylor, Tilley, Tomita, Tschopp, Tweten, Voskoboinik, Wade, Wade, Walker   +75 more
core   +2 more sources

Serum antibodies to pneumolysin in patients with pneumonia [PDF]

Journal of Clinical Microbiology, 1988
Serum antibodies to purified pneumolysin were determined by enzyme-linked immunosorbent assay (ELISA) in paired samples from 406 adult patients with community-acquired pneumonia and in samples from 184 healthy controls. A high sensitivity (83%) was obtained in patients with blood culture-confirmed pneumococcal pneumonia.
K, Kanclerski, S, Blomquist, M, Granström, R, Möllby   +3 more
openaire   +2 more sources

Neuroimmune interactions: The bridge between inflammatory bowel disease and the gut microbiota

Clinical and Translational Medicine, Volume 15, Issue 5, May 2025.
The gut microbiota regulates the gut–brain–immune axis, modulating neuroimmune interactions in inflammatory bowel disease (IBD). Microbiota‐derived metabolites influence immune cells, driving cytokine release that activates dorsal root ganglion (DRG) neurons.
Jinxia Zhai, Yingjie Li, Jiameng Liu, Cong Dai   +3 more
wiley   +1 more source

Weakened Airway Epithelial Junctions and Enhanced Neutrophil Elastase Release Contribute to Age‐Dependent Bacteremia Risk Following Pneumococcal Pneumonia

Aging Cell, Volume 24, Issue 5, May 2025.
During spread of Streptococcus pneumoniae from the lung to the bloodstream, the pneumococcal pore‐forming toxin pneumolysin (PLY) disrupts apical junction complexes (AJCs) and triggers the transmigration of polymorphonuclear leukocytes (PMNs), which secrete tissue‐destructive neutrophil elastase.
Shuying Xu, Tianmou Zhu, Hongmei Mou, Shumin Tan, John M. Leong   +4 more
wiley   +1 more source

Subunit organisation and symmetry of pore‐forming, oligomeric pneumolysin [PDF]

FEBS Letters, 1995
We present a detailed analysis of the oligomeric subunit organisation of pneumolysin by the use of negative stain electron microscopy and image processing to produce a projection density map. Analysis of the rotational symmetry has revealed a large and variable subunit number, between 40–50.
Morgan, PJ, Hyman, SC, Rowe, AJ, Mitchell, TJ, Andrew, PW, Saibil, HR   +5 more
openaire   +3 more sources

The putative proteinase maturation protein A of Streptococcus pneumoniae is a conserved surface protein with potential to elicit protective immune responses [PDF]

, 2000
Surface-exposed proteins often play an important role in the interaction between pathogenic bacteria and their host. We isolated a pool of hydrophobic, surface-associated proteins of Streptococcus pneumoniae.
Groot, R. (Ronald) de, Hermans, P.W.M. (Peter), Jackson, M.H., Jong, A.P. de, Kerr, A., Mitchell, T.J., Overweg, K. (Karin), Sluijter, M. (Marcel)   +7 more
core   +2 more sources

Acacetin: A Panorama of Biological Sources, Multitarget Pharmacological Actions, Pharmacokinetics, and Toxicology

Journal of Chemistry, Volume 2025, Issue 1, 2025.
Acacetin, a naturally occurring flavonoid abundant in various medicinal and edible plants, has garnered increasing attention as a potential therapeutic agent due to its broad pharmacological properties and low cytotoxicity. Although most current research on acacetin remains limited to cellular and animal studies, its diverse bioactivities ...
Jianxiu Zhang, Hui Li, Fengxia Yuan, Qinglong Cui, Di Wu, Hongxuan Li, Xi Zhang, Mulangma Zhu, Guangchun Piao, Haidan Yuan, Sohini Basu Roy   +10 more
wiley   +1 more source

Allicin from garlic neutralizes the hemolytic activity of intra- and extra-cellular pneumolysin O in vitro [PDF]

Pneumolysin (PLY) is a key virulence factor contributes to the pathogenesis of Streptococcus pneumoniae. In this study we investigated the effect of allicin and aqueous garlic extracts on hemolytic activity of PLY both in prelysed and intact cells ...
ارزنلو, محسن, بهلولی, شهاب, جنتی, الهام, میرزانژاد اصل, حافظ   +3 more
core   +1 more source

Neurotoxizität von Pneumolysin

, 2008
S. pneumoniae is one of the major keys in bacterial meningitis. Neurological sequelae are frequent and severe. The reason for it is apoptosis. Here we showed that Pneumolysin, a membrane binding and pore forming toxin of pneumococci plays an important role in triggering neuronal cell death of primary rat neurons in vitro.
openaire   +1 more source