Results 61 to 70 of about 7,584 (199)

Pneumolysin activates phospholipase A in pulmonary artery endothelial cells [PDF]

Infection and Immunity, 1994
Pneumolysin has been identified as a virulence factor in Streptococcus pneumoniae disease. In addition to producing tissue injury through its cytolytic effect, pneumolysin might injure tissues indirectly by eliciting an inflammatory response. We demonstrate for the first time that pneumolysin is a rapid and potent activator of cellular phospholipase A ...
J B, Rubins, T J, Mitchell, P W, Andrew, D E, Niewoehner   +3 more
openaire   +2 more sources

Electrical cell‐substrate impedance sensing (ECIS) in lung biology and disease

Applied Research, Volume 3, Issue 6, December 2024.
This mini‐review summarizes recent progress in electrical cell‐substrate impedance sensing of primary lung endothelial and epithelial cells as well as fibroblasts to quantify cell barrier functions in lung biology and disease. Abstract The lungs are exposed to a hostile environment from both sites: the airways and the vasculature. However, an efficient
Lena Schaller, Katharina Hofmann, Fabienne Geiger, Alexander Dietrich   +3 more
wiley   +1 more source

Characterization of Streptococcus pneumoniae isolates from Austrian companion animals and horses [PDF]

, 2017
Background: The aim of the present study was to investigate the genetic relatedness and the antimicrobial resistance profiles of a collection of Austrian Streptococcus pneumoniae isolates from companion animals and horses.
Eichhorn, Inga, Fessler, Andrea T., Ginders, Maximilian, Kampner, Doris, Künzel, Frank, Leschnik, Michael, Loncaric, Igor, Mikula, Claudia, Schwarz, Stefan, Spergser, Joachim, Steindl, Georg   +10 more
core   +1 more source

Exploring Bioactive Phytomedicines for Advancing Pulmonary Infection Management: Insights and Future Prospects

Phytotherapy Research, Volume 38, Issue 12, Page 5840-5872, December 2024.
ABSTRACT Pulmonary infections have a profound influence on global mortality rates. Medicinal plants offer a promising approach to address this challenge, providing nontoxic alternatives with higher levels of public acceptance and compliance, particularly in regions where access to conventional medications or diagnostic resources may be limited ...
Joyce Siaw Syuen Ho, Teh Li Ping, Keshav Raj Paudel, Tammam El Sherkawi, Gabriele De Rubis, Stewart Yeung, Philip M. Hansbro, Brian Gregory George Oliver, Dinesh Kumar Chellappan, Keng Pei Sin, Kamal Dua   +10 more
wiley   +1 more source

Pneumoccal Hemolysin [PDF]

, 1971
The purposes of this report are to describe a method of preparing a potent crude pneumococcal hemolysin, to define some of it characteristics, and to describe the effects of its administration to ...
Shumway, Clare N.
core   +1 more source

Impaired CD4 T Cell Memory Response to Streptococcus pneumoniae Precedes CD4 T Cell Depletion in HIV-Infected Malawian Adults [PDF]

, 2011
Objective: Invasive pneumococcal disease (IPD) is a leading cause of morbidity and mortality in HIV-infected African Adults. CD4 T cell depletion may partially explain this high disease burden but those with relatively preserved T cell numbers are still ...
Glennie, Sarah, Gordon, Stephen, Harawa, Visopo, Heyderman, Robert, Jambo, Kondwani, Miles, David J.C., Mzinza, David, Sepako, Enoch, Williams, Neil A   +8 more
core   +4 more sources

Hyaluronidase augments pneumolysin-mediated injury to human ciliated epithelium [PDF]

International Journal of Infectious Diseases, 2007
The main objective of this study was to investigate the effects of pneumococcal hyaluronidase (0.1-10microg/ml), alone and in combination with pneumolysin (50 and 100ng/ml), on human ciliated epithelium.Ciliary beat frequency (CBF) and structural integrity of human ciliated respiratory epithelium in vitro were studied using a phototransistor technique ...
Feldman, C., Cockeran, R., Jedrzejas, M.J., Mitchell, T.J., Anderson, R.   +4 more
openaire   +2 more sources

Pushing the Limits of Lateral Flow Immunoassay by Digital SERS for the Ultralow Detection of SARS‐CoV‐2 Virus

Small Science, Volume 4, Issue 11, November 2024.
A digital surface‐enhanced Raman spectroscopy (SERS)‐based LFIA for the accurate and ultrasensitive quantitative detection of SARS‐CoV‐2 nucleocapsid (N) protein is implemented. The method shows limits of detection down to 1.9 aM (0.9 fg mL−1), improving conventional‐SERS‐based LFIAs by several orders of magnitude.
Lara González‐Cabaleiro, Carlos Fernández‐Lodeiro, Lorena Vázquez‐Iglesias, Pablo Soriano‐Maldonado, Mark J. van Raaij, Gustavo Bodelón, Jorge Pérez‐Juste, Isabel Pastoriza‐Santos   +7 more
wiley   +1 more source

IL-17 can be protective or deleterious in murine pneumococcal pneumonia [PDF]

, 2018
Streptococcus pneumoniae is the major bacterial cause of community-acquired pneumonia, and the leading agent of childhood pneumonia deaths worldwide. Nasal colonization is an essential step prior to infection.
Bayes, Hannah K., Evans, Tom J., Mitchell, Tim J., Ritchie, Neil D., Ritchie, Ryan   +4 more
core   +3 more sources

Characterising the allergic fungal rhinosinusitis microenvironment using full‐length 16S rRNA gene amplicon sequencing and fungal ITS sequencing

Allergy, Volume 79, Issue 11, Page 3082-3094, November 2024.
Sinonasal swabs from 61 patients underwent DNA extraction and multimodal gene amplicon sequencing to define the microbiome and mycobiome of AFRS. The AFRS microbiome exhibited low bacterial diversity and was dominated by Staphylococcus aureus, Streptococcus pneumoniae and Haemophilus influenzae.
J. T. Connell, G. Bouras, K. Yeo, K. Fenix, C. Cooksley, A. Bassiouni, S. Vreugde, P. J. Wormald, A. J. Psaltis   +8 more
wiley   +1 more source