Results 71 to 80 of about 7,584 (199)

Presence of Nonhemolytic Pneumolysin in Serotypes of Streptococcus pneumoniae Associated with Disease Outbreaks [PDF]

, 2017
Pneumolysin is an important virulence factor of the human pathogen Streptococcus pneumoniae. Sequence analysis of the ply gene from 121 clinical isolates of S. pneumoniae uncovered a number of alleles. Twenty-two strains were chosen for further analysis,
Brueggemann, Angela B., Clarke, Stuart C., Cowan, Graeme J. M., George, Robert C., Jefferies, Johanna M. C., Johnston, Calum H. G., Kirkham, Lea-Ann S., Mitchell, Tim J., Pflüger, Valentin, Pichon, Bruno, Pluschke, Gerd, Ross, Kirsty S., Smith, Andrew   +12 more
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Pneumococcal Gene Complex Involved in Resistance to Extracellular Oxidative Stress [PDF]

, 2012
Streptococcus pneumoniae is a Gram-positive bacterium which is a member of the normal human nasopharyngeal flora but can also cause serious disease such as pneumonia, bacteremia, and meningitis. Throughout its life cycle, S.
Anne de Jong, Barbuti, Battig, Bijlsma, Bogaert, Bortoni, Braun, Brot, Bus, Carlos J. Orihuela, Cecilia A. Hinojosa, Chae, Chen, de Ruyter, Dopazo, Duane, Even, Falord, Haasum, Hendriksen, Hiller, Hirst, Holmgren, Holmgren, Hoshi, Hoskins, Ibrahim, Imlay, Imlay, J. N. Weiser, Jetta J. E. Bijlsma, Kadioglu, Kim, Kloosterman, Kloosterman, Kuipers, Lau, Liu, Liu, Liu, Marchler-Bauer, Margolis, Martner, Matthias, McAllister, Miller, Neef, Novak, Obert, Orihuela, Oscar P. Kuipers, Park, Parra-Lopez, Paterson, Pearce, Pericone, Pericone, Pericone, Pesakhov, Petit, Potter, Ramos-Montanez, Regev-Yochay, Robertson, Rosen, Schaper, Skaar, Spellerberg, Sun, Terzaghi, Tettelin, Tseng, Vahid Farshchi Andisi, Yesilkaya, Ziegelhoffer, Zweers   +75 more
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The Complete Assessment of Small Molecule and Peptidomimetic Inhibitors of Sortase A Towards Antivirulence Treatment

Chemistry – A European Journal, Volume 30, Issue 38, July 5, 2024.
This review covers the most recent advances in the development of inhibitors for the bacterial enzyme sortase A (SrtA), where it is considered as a major target for antivirulence therapy. Sortases are key enzymes regulating bacterial adherence to host cells and are considered major virulence factors.
Jordi C. J. Hintzen, Helal Abujubara, Daniel Tietze, Alesia A. Tietze   +3 more
wiley   +1 more source

Linking innate and adaptive immunity to streptococcus pneumoniae [PDF]

, 2012
Streptococcus pneumoniae (the pneumococcus) most commonly colonizes the human nasopharyngeal mucosa without causing any symptoms. However, this organism has the potential to spread to normally sterile sites and cause pneumonia, meningitis or sepsis ...
Olliver, Marie
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In Silico Identification and Characterization of Drug Targets in Streptococcus pneumoniae ATCC 700669 (Serotype 23F) by Subtractive Genomics

BioMed Research International, Volume 2024, Issue 1, 2024.
Streptococcus pneumoniae (S. pneumoniae) is an important pathogen worldwide that causes pneumococcal infections which are related to high rates of morbidity and mortality especially in young children, older adults, and immune‐compromised persons. Antibiotic resistance in S.
Tolossa Duguma, Hunduma Dinka, Shibiao Wan   +2 more
wiley   +1 more source

Contributions of the pore-forming toxin Listeriolysin O to Listeria monocytogenes pathogenesis [PDF]

, 2019
Listeriolysin O (LLO) is an essential determinant of Listeria monocytogenes pathogenesis that mediates the escape of L. monocytogenes from host cell vacuoles, thereby allowing replication in the cytosol without causing appreciable cell death. As a member
Nguyen, Brittney Nhu-Chau
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Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice [PDF]

, 2014
Gram-positive bacterial pathogens that secrete cytotoxic pore-forming toxins, such as Staphylococcus aureus and Streptococcus pneumoniae, cause a substantial burden of disease.
Babiychuk, Eduard B, Becker, Katrin Anne, Bricio Moreno, Laura, Draeger, Annette, Edwards, Michael J, Gore, Suzanna, Gulbins, Erich, Henry, Brian D, Japtok, Lukasz, Kadioglu, Aras, Kleuser, Burkhard, Luginbühl, Miriam, Mühlemann, Kathrin, Neill, Daniel, Scherag, André, Steinmann, Jörg, Wolfmeier, Heidi, Ziobro, Regan   +17 more
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Phenotypic and Molecular Investigation of Streptococcus pneumoniae pneumolysin

, 2023
Roaa Thamer, Amera Mahmood AL-RAWI
openalex   +1 more source

Investigation of Listeria monocytogenes and Streptococcus pneumoniae mutants in in vivo models of infection [PDF]

, 2015
Dissertação de Mestrado, Engenharia Biológica, Faculdade de Ciências e Tecnologia, Universidade do Algarve, 2016Listeria monocytogenes é o agente etiológico da listeriose, uma doença que afeta predominantemente indivíduos imunocomprometidos, fetos, recém-
Porfírio, Ana Raquel Chaves Mendes de Alves
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Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity [PDF]

, 2020
Stavros Panagiotou, Chrispin Chaguza, Reham Yahya, Teerawit Audshasai, Murielle Baltazar, Lorenzo Ressel, Shadia Khandaker, Mansoor Alsahag, Timothy J. Mitchell, Marc Prudhomme, Aras Kadioglu, Marie Yang   +11 more
openalex   +1 more source