The ribonuclease PNPase is a key regulator of biofilm formation in Listeria monocytogenes and affects invasion of host cells [PDF]
Npj Biofilms and Microbiomes, 2023 Biofilms provide an environment that protects microorganisms from external stresses such as nutrient deprivation, antibiotic treatments, and immune defences, thereby creating favorable conditions for bacterial survival and pathogenesis. Here we show that
Ana Patrícia Quendera +2 more
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RNase E biomolecular condensates stimulate PNPase activity [PDF]
Scientific Reports, 2023 Bacterial Ribonucleoprotein bodies (BR-bodies) play an essential role in organizing RNA degradation via phase separation in the cytoplasm of bacteria. BR-bodies mediate multi-step mRNA decay through the concerted activity of the endoribonuclease RNase E ...
Michael J. Collins +4 more
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A PNPase Dependent CRISPR System in Listeria [PDF]
PLoS Genetics, 2014 The human bacterial pathogen Listeria monocytogenes is emerging as a model organism to study RNA-mediated regulation in pathogenic bacteria. A class of non-coding RNAs called CRISPRs (clustered regularly interspaced short palindromic repeats) has been ...
Eduardo P C Rocha +2 more
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Lack of PNPase activity in Enterococcus faecalis 14 increases the stability of EntDD14 bacteriocin transcripts [PDF]
Scientific Reports, 2023 A mutant deficient in polynucleotide phosphorylase (PNPase) activity was previously constructed in Enterococcus faecalis 14; a strain producing a leaderless two-peptide enterocin DD14 (EntDD14).
Rabia Ladjouzi +3 more
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Impact of PNPase on the transcriptome of Rhodobacter sphaeroides and its cooperation with RNase III and RNase E [PDF]
BMC Genomics, 2021 Background The polynucleotide phosphorylase (PNPase) is conserved among both Gram-positive and Gram-negative bacteria. As a core part of the Escherichia coli degradosome, PNPase is involved in maintaining proper RNA levels within the bacterial cell.
Daniel-Timon Spanka +2 more
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Microbiology Spectrum, 2022 8-Oxo-7,8-dihydroguanine (8-oxoG) is a major RNA modification caused by oxidative stresses and has been implicated in carcinogenesis, neurodegeneration, and aging.
Runhua Han +3 more
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Regulation and functions of bacterial PNPase [PDF]
Wiley Interdisciplinary Reviews RNA, 2016 Polynucleotide phosphorylase (PNPase) is an exoribonuclease that catalyzes the processive phosphorolytic degradation of RNA from the 3\u2032-end. The enzyme catalyzes also the reverse reaction of polymerization of nucleoside diphosphates that has been ...
Federica Briani +2 more
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Human PNPase causes RNA stabilization and accumulation of R-loops in the Escherichia coli model system [PDF]
Scientific Reports, 2023 Polyribonucleotide phosphorylase (PNPase) is a phosphorolytic RNA exonuclease highly conserved throughout evolution. In Escherichia coli, PNPase controls complex phenotypic traits like biofilm formation and growth at low temperature.
Federica A. Falchi +7 more
doaj +6 more sources
PNPase knockout results in mtDNA loss and an altered metabolic gene expression program
PLoS ONE, 2018 Polynucleotide phosphorylase (PNPase) is an essential mitochondria-localized exoribonuclease implicated in multiple biological processes and human disorders.
Michael A Teitell +2 more
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PNPase is involved in the coordination of mRNA degradation and expression in stationary phase cells of Escherichia coli [PDF]
BMC Genomics, 2018 Background Exoribonucleases are crucial for RNA degradation in Escherichia coli but the roles of RNase R and PNPase and their potential overlap in stationary phase are not well characterized.
Laurence Girbal +2 more
exaly +10 more sources