Results 91 to 100 of about 5,147 (230)

8‐Aminoguanine Induces Diuresis, Natriuresis, and Glucosuria by Inhibiting Purine Nucleoside Phosphorylase and Reduces Potassium Excretion by Inhibiting Rac1

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background 8‐Aminoguanosine and 8‐aminoguanine are K+‐sparing natriuretics that increase glucose excretion. Most effects of 8‐aminoguanosine are due to its metabolism to 8‐aminoguanine.
Edwin K. Jackson, Zaichuan Mi, Thomas R. Kleyman, Dongmei Cheng   +3 more
doaj   +1 more source

Estimating the size of the solution space of metabolic networks [PDF]

, 2007
In this work we propose a novel algorithmic strategy that allows for an efficient characterization of the whole set of stable fluxes compatible with the metabolic constraints.
Braunstein, Alfredo, Mulet, Roberto, Pagnani, Andrea   +2 more
core   +4 more sources

The ribonuclease E regulator RebA is essential for diazotrophic growth in the cyanobacterium Anabaena PCC 7120

mLife, Volume 4, Issue 5, Page 516-526, October 2025.
Abstract Ribonuclease E (RNase E) is central to bacterial RNA metabolism. In cyanobacteria, its activity is inhibited by RebA, a key mechanism for controlling cell morphology. Here, we demonstrate that rebA is essential for diazotrophic growth of Anabaena PCC 7120, a filamentous cyanobacterium capable of forming heterocysts—specialized nitrogen‐fixing ...
Sujuan Liu, Zhenyu Wang, Guiming Lin, Wenkai Li, Xiaoli Zeng, Ju‐Yuan Zhang, Cheng‐Cai Zhang   +6 more
wiley   +1 more source

Elucidating the molecular physiology of lantibiotic NAI-107 production in Microbispora ATCC-PTA-5024 [PDF]

, 2016
BACKGROUND: The filamentous actinomycete Microbispora ATCC-PTA-5024 produces the lantibiotic NAI-107, which is an antibiotic peptide effective against multidrug-resistant Gram-positive bacteria. In actinomycetes, antibiotic production is often associated
Alduina, Rosa, Arena, Simona, Faddetta, Teresa, Gallo, Giuseppe, Giardina, Anna, Monciardini, Paolo, Palazzotto, Emilia, Puglia, Anna Maria, Renzone, Giovanni, Russo, Alessandro, Sangiorgi, Fabio, Scaloni, Andrea, Sosio, Margherita, Spinelli, Giovanni, Weber, Tilmann   +14 more
core   +4 more sources

Skeletal Muscle Mitochondria Contain Nuclear‐Encoded RNA Species Prior to and Following Adaptation to Exercise Training in Rats

The FASEB Journal, Volume 39, Issue 13, 15 July 2025.
Here, we report that mitochondria from rat skeletal muscle contain a select population of nuclear‐encoded protein‐coding and noncoding RNAs, including 3 microRNAs whose expression tended to be altered by exercise training. These findings suggest that mitochondria‐localized nuclear‐encoded RNAs may play a role in mediating the beneficial adaptive ...
Jessica L. Silver, Séverine Lamon, Stella Loke, Gisella Mazzarino, Larry Croft, Mark Ziemann, Megan Soria, Glenn D. Wadley, Adam J. Trewin   +8 more
wiley   +1 more source

Using in silico models to simulate dual perturbation experiments: procedure development and interpretation of outcomes. [PDF]

, 2009
BackgroundA growing number of realistic in silico models of metabolic functions are being formulated and can serve as 'dry lab' platforms to prototype and simulate experiments before they are performed.
Jamshidi, Neema, Palsson, Bernhard O
core   +3 more sources

Phase Separation Regulates Metabolism, Mitochondria, and Diseases

MedComm, Volume 6, Issue 7, July 2025.
Mitochondrion‐related liquid–liquid phase separation. (1) Phase separation mediates the self‐assembly of mitochondrial nucleoids (mt‐nucleoids). (2) Phase segregation mediates the formation of mitochondrial RNA granules (MRGs). (3) Phase separation mediates the formation of mitochondrial degradosomes.
Chuan Gao, Peng Ding, Changqing Zhang, Junjie Gao   +3 more
wiley   +1 more source

Defective Processing of Cytoplasmic and Chloroplast Ribosomal RNA in the Absence of Arabidopsis DXO1

Plant, Cell &Environment, Volume 48, Issue 6, Page 4227-4244, June 2025.
ABSTRACT Decapping 5′‐3′ exoribonucleases from the DXO/Rai1 family are highly conserved among eukaryotes and exhibit diverse enzymatic activities depending on the organism. The biochemical and structural properties of the plant DXO1 differ from the yeast and animal counterparts, which is reflected in the in vivo functions of this enzyme.
Monika Zakrzewska‐Placzek, Anna Golisz‐Mocydlarz, Aleksandra Kwasnik, Michal Krzyszton, Katarzyna Niedzwiecka, Joanna Kufel   +5 more
wiley   +1 more source

An RNA-seq based comparative approach reveals the transcriptome-wide interplay between 3′-to-5′ exoRNases and RNase Y

Nature Communications, 2020
Bacterial RNA degradation is typically initiated by endoribonucleases and followed by exoribonucleases. Here the authors report the targetome of endoRNase Y in Streptococcus pyogenes, revealing the interplay between RNase Y and 3′-to-5′ exoribonuclease ...
Laura Broglia, Anne-Laure Lécrivain, Thibaud T. Renault, Karin Hahnke, Rina Ahmed-Begrich, Anaïs Le Rhun, Emmanuelle Charpentier   +6 more
doaj   +1 more source

Crystal structure of the S. solfataricus archaeal exosome reveals conformational flexibility in the RNA-binding ring. [PDF]

PLoS ONE, 2010
The exosome complex is an essential RNA 3'-end processing and degradation machinery. In archaeal organisms, the exosome consists of a catalytic ring and an RNA-binding ring, both of which were previously reported to assume three-fold symmetry.Here we ...
Changrui Lu, Fang Ding, Ailong Ke
doaj   +1 more source