Results 101 to 110 of about 4,071 (219)

A Mutation in PNPT1, Encoding Mitochondrial-RNA-Import Protein PNPase, Causes Hereditary Hearing Loss [PDF]

The American Journal of Human Genetics, 2012
A subset of nuclear-encoded RNAs has to be imported into mitochondria for the proper replication and transcription of the mitochondrial genome and, hence, for proper mitochondrial function. Polynucleotide phosphorylase (PNPase or PNPT1) is one of the very few components known to be involved in this poorly characterized process in mammals.
Simon von Ameln, Geng Wang, Redouane Boulouiz, Mark A. Rutherford, Geoffrey Smith, Yun Li, Hans‐Martin Pogoda, Gudrun Nürnberg, Barbara Stiller, Alexander E. Volk, Guntram Borck, Jason Hong, Richard J. Goodyear, Omar Abidi, Peter Nürnberg, Kay Hofmann, Guy P. Richardson, Matthias Hammerschmidt, Tobias Moser, Bernd Wollnik, Carla M. Koehler, Michael A. Teitell, Abdelhamid Barakat, Christian Kubisch   +23 more
openalex   +5 more sources

The RNA processing enzyme polynucleotide phosphorylase negatively controls biofilm formation by repressing poly-N-acetylglucosamine (PNAG) production in Escherichia coli C

BMC Microbiology, 2012
Background Transition from planktonic cells to biofilm is mediated by production of adhesion factors, such as extracellular polysaccharides (EPS), and modulated by complex regulatory networks that, in addition to controlling production of adhesion ...
Carzaniga Thomas, Antoniani Davide, Dehò Gianni, Briani Federica, Landini Paolo   +4 more
doaj   +1 more source

Single‐Molecule Electrical Profiling of Peptides and Proteins

Advanced Science, Volume 11, Issue 28, July 24, 2024.
This work presents a timely overview of the prominent research progress in peptide and protein‐related studies through single‐molecule electrical techniques, including single‐molecule junction, single‐molecule field‐effect transistor (FET), and nanopore.
Hongyu Ju, Li Cheng, Mengmeng Li, Kunrong Mei, Suhang He, Chuancheng Jia, Xuefeng Guo   +6 more
wiley   +1 more source

Biomolecular Condensates: From Bacterial Compartments to Incubator Spaces of Emergent Chemical Systems in Matter‐to‐Life Transitions

ChemSystemsChem, Volume 6, Issue 4, July 2024.
This review examines discoveries of biomolecular condensates as compartments in bacteria. Insights from bacterial cell biology and systems chemistry reveal intricate connections between chemical reactions and the control of condensate phase separation.
Wade E. Schnorr, W. Seth Childers
wiley   +1 more source

Mitochondrial sequencing identifies long noncoding RNA features that promote binding to PNPase.

Am J Physiol Cell Physiol
Long noncoding RNAs (lncRNAs) are relatively novel RNAs with increasingly prominent roles in regulating genetic expression, mainly in the nucleus but more recently in regions such as the mitochondrion. This study explores how lncRNAs interact with polynucleotide phosphorylase (PNPase), a protein that regulates RNA import into the mitochondrion ...
Taylor AD, Hathaway QA, Kunovac A, Pinti MV, Newman MS, Cook CC, Cramer ER, Starcovic SA, Winters MT, Westemeier-Rice ES, Fink GK, Durr AJ, Rizwan S, Shepherd DL, Robart AR, Martinez I, Hollander JM.   +16 more
europepmc   +3 more sources

Analysis on relationship between extreme pathways and correlated reaction sets [PDF]

, 2009
Background: Constraint-based modeling of reconstructed genome-scale metabolic networks has been successfully applied on several microorganisms. In constraint-based modeling, in order to characterize all allowable phenotypes, network-based pathways, such ...
Cao, Ming, Chen, Yi-Ping Phoebe, Wang, Fei, Wang, Weirong, Xi, Yanping   +4 more
core   +3 more sources

A type III-A CRISPR-Cas system employs degradosome nucleases to ensure robust immunity

eLife, 2019
CRISPR-Cas systems provide sequence-specific immunity against phages and mobile genetic elements using CRISPR-associated nucleases guided by short CRISPR RNAs (crRNAs).
Lucy Chou-Zheng, Asma Hatoum-Aslan
doaj   +1 more source

Antibiotic influx and efflux in Pseudomonas aeruginosa: Regulation and therapeutic implications

Microbial Biotechnology, Volume 17, Issue 5, May 2024.
This work comprehensively summarized the regulatory networks of the major porin proteins and efflux pumps that play critical roles in antibiotic influx and efflux in Pseudomonas aeruginosa. It also discussed promising therapeutic approaches to combat multidrug‐resistant P.
Weiyan Wu, Jiahui Huang, Zeling Xu
wiley   +1 more source

Nuclear Surveillance and Degradation of Hypomodified Initiator tRNA\u3csup\u3eMet\u3c/sup\u3e in \u3cem\u3eS. cerevisiae\u3c/em\u3e [PDF]

, 2004
The tRNA m1A58 methyltransferase is composed of two subunits encoded by the essential genes TRM6 and TRM61 (formerly GCD10 and GCD14). The trm6-504 mutation results in a defective m1A methyltransferase (Mtase) and a temperature-sensitive growth phenotype
Anderson, James T., Hinnebusch, Alan G., Kadaba, Sujatha, Krecic, Annette M., Krueger, Anna, Trice, Tamyra   +5 more
core   +1 more source

Polynucleotide phosphorylase exonuclease and polymerase activities on single-stranded DNA ends are modulated by RecN, SsbA and RecA proteins [PDF]

, 2011
Bacillus subtilis pnpA gene product, polynucleotide phosphorylase (PNPase), is involved in double-strand break (DSB) repair via homologous recombination (HR) or non-homologous end-joining (NHEJ).
Aguilera, Alonso, Arenghi, Ayora, Beljanski, Bermudez-Cruz, Campos-Guillen, Cardenas, Carrasco, Carrasco, Cejka, Chou, Condon, Cox, Daly, Daly, Deikus, Del Favero, Deutscher, Egelman, Esther Garcia-Tirado, Federica Briani, Galletto, Gianni Dehò, Gillam, Gravel, Grunberg-Manago, Heitman, Henner, Heuser, Hopkins, Huertas, Jarrige, Juan C. Alonso, Kidane, Kosa, Kushner, Lehnik-Habrink, Lengsfeld, Lisby, Lisby, Littauer, Lovett, Mimitou, Mimitou, Mohanty, Moreno-Herrero, Nimonkar, Niu, Niu, Ochoa, Paula P. Cardenas, Paull, Picksley, Pâques, Register, Regonesi, San Filippo, Sanchez, Sanchez, Sanchez, Sandro Zangrossi, Sarkar, Sartori, Shuman, Sinha, Sperandeo, Stracker, Taghbalout, Thomas Carzaniga, Tomita, Trujillo, Wasko, Wu, Yeeles, Zhu   +75 more
core   +2 more sources