Results 21 to 30 of about 5,147 (230)

Role of the PNPase enzyme in the transport of mtRNA in lymphatic cancer: Bibliographic review

Nereis. Interdisciplinary Ibero-American Journal of Methods, Modelling and Simulation., 2021
Lymphoma is the most common type of blood cancer today and, as its name suggests, it begins in the lymphatic system. The origin of this disease is related to mitochondrial defects, generated by mutations in the PNPase enzyme or polynucleotide ...
Myriam Lizanda Piqueras, Ignacio Ventura
semanticscholar   +5 more sources

The small RNA SraG participates in PNPase homeostasis [PDF]

RNA, 2016
The rpsO-pnp operon encodes ribosomal protein S15 and polynucleotide phosphorylase, a major 3′–5′ exoribonuclease involved in mRNA decay in Escherichia coli. The gene for the SraG small RNA is located between the coding regions of the rpsO and pnp genes,
Fanette Fontaine, Elise Gasiorowski, Céline Gracia, Mathieu Ballouche, J. Caillet, Antonin Marchais, Eliane Hajnsdorf   +6 more
semanticscholar   +7 more sources

The PNPase, exosome and RNA helicases as the building components of evolutionarily-conserved RNA degradation machines [PDF]

Journal of Biomedical Science, 2007
The structure and function of polynucleotide phosphorylase (PNPase) and the exosome, as well as their associated RNA-helicases proteins, are described in the light of recent studies. The picture raised is of an evolutionarily conserved RNA-degradation machine which exonucleolytically degrades RNA from 3' to 5'.
Sue Lin-Chao, Gadi Schuster
exaly   +5 more sources

Target recognition by RNase E RNA-binding domain AR2 drives sRNA decay in the absence of PNPase

Proceedings of the National Academy of Sciences, 2022
Significance RNase E performs an indispensable function in gram-negative bacteria by initiating breakdown of cellular RNAs and providing the scaffold for the primary RNA decay machine, the RNA degradosome.
Dhriti Sinha, Nicholas R. De Lay
semanticscholar   +5 more sources

The ribonuclease PNPase is a key regulator of biofilm formation in Listeria monocytogenes and affects invasion of host cells

npj Biofilms and Microbiomes, 2023
Biofilms provide an environment that protects microorganisms from external stresses such as nutrient deprivation, antibiotic treatments, and immune defences, thereby creating favorable conditions for bacterial survival and pathogenesis. Here we show that
Ana Patrícia Quendera, Sandra Nunes Pinto, Vânia Pobre, Wilson Antunes, Vasco D. B. Bonifácio, Cecília Maria Arraiano, José Marques Andrade   +6 more
doaj   +2 more sources

Exploring the mitochondrial microRNA import pathway through Polynucleotide Phosphorylase (PNPase). [PDF]

Journal of Molecular and Cellular Cardiology, 2017
Cardiovascular disease is the primary cause of mortality for individuals with type 2 diabetes mellitus. During the diabetic condition, cardiovascular dysfunction can be partially attributed to molecular changes in the tissue, including alterations in microRNA (miRNA) interactions.
D. Shepherd, Quincy A. Hathaway, M. Pinti, C. Nichols, A. Durr, S. Sreekumar, K. M. Hughes, Seth M Stine, Ivan Martinez, J. Hollander   +9 more
semanticscholar   +3 more sources

Structure and function of Campylobacter jejuni polynucleotide phosphorylase (PNPase): Insights into the role of this RNase in pathogenicity.

Biochimie, 2023
Ribonucleases are in charge of the processing, degradation and quality control of all cellular transcripts, which makes them crucial factors in RNA regulation. This post-transcriptional regulation allows bacteria to promptly react to different stress conditions and growth phase transitions, and also to produce the required virulence factors in ...
C. Bárria, Diogo Athayde, G. Hernandez, Leonor Fonseca, Jorge Casinhas, Tiago N. Cordeiro, Margarida Archer, C. Arraiano, José A. Brito, R. Matos   +9 more
semanticscholar   +3 more sources

Regulatory Mechanisms of Exoribonuclease PNPase and Regulatory Small RNA on T3SS of Dickeya dadantii [PDF]

Molecular Plant-Microbe Interactions, 2010
The type III secretion system (T3SS) is an essential virulence factor for many bacterial pathogens. Polynucleotide phosphorylase (PNPase) is one of the major exoribonucleases in bacteria and plays important roles in mRNA degradation, tRNA processing, and
Quan Zeng, A. Mark Ibekwe, Eulandria Biddle, Ching-Hong Yang   +3 more
doaj   +3 more sources

RNase R vs. PNPase: selecting the best-suited exoribonuclease for environmental adaptation

Extremophiles
3' → 5' exoribonucleases play a critical role in many aspects of RNA metabolism. RNase R, PNPase, and RNase II are the major contributors to RNA processing, maturation, and quality control in bacteria. Bacteria don't seem to have dedicated RNA degradation machineries to process different classes of RNAs.
T. Pavankumar
semanticscholar   +5 more sources

Mitochondrial sequencing identifies long noncoding RNA features that promote binding to PNPase.

Am J Physiol Cell Physiol
Extranuclear localization of long non-coding RNAs (lncRNAs) is poorly understood. Based on machine learning evaluations, we propose a lncRNA-mitochondrial interaction pathway where Polynucleotide Phosphorylase (PNPase), through domains that provide ...
Taylor AD, Hathaway QA, Kunovac A, Pinti MV, Newman MS, Cook CC, Cramer ER, Starcovic SA, Winters MT, Westemeier-Rice ES, Fink GK, Durr AJ, Rizwan S, Shepherd DL, Robart AR, Martinez I, Hollander JM.   +16 more
europepmc   +4 more sources