Results 51 to 60 of about 5,147 (230)

Heterozygous PNPT1 Variants Cause a Sensory Ataxic Neuropathy. [PDF]

Eur J Neurol
ABSTRACT Background Biallelic variants in polyribonucleotide‐nucleotidyltransferase‐1 (PNPT1) have been associated with a range of phenotypes from syndromic hearing loss to Leigh's syndrome. More recently, heterozygous variants in PNPT1, have been reported in three families with cerebellar ataxia and prominent sensory neuropathy.
Haddad S, Record CJ, Self E, Skorupinska M, Rossor AM, Laura M, Ingle G, Manzur A, Muntoni F, Blake JC, Reilly MM.   +10 more
europepmc   +2 more sources

The human exosome and PNPase. Molecular machines for controlled RNA degradation [PDF]

, 2004
The human exosome is a multi-protein complex present in all eukaryotic cells, which is involved in the processing and degradation of a large variety of RNA molecules. In patients suffering from an overlap syndrome of the autoimmune diseases polymyositis (PM) and scleroderma (Scl), autoantibodies are found that are reactive with protein subunits of this
Reinout Raijmakers
openalex   +2 more sources

Analysis of mRNA Decay Intermediates in Bacillus subtilis 3′ Exoribonuclease and RNA Helicase Mutant Strains

mBio, 2022
The Bacillus subtilis genome encodes four 3′ exoribonucleases: polynucleotide phosphorylase (PNPase), RNase R, RNase PH, and YhaM. Previous work showed that PNPase, encoded by the pnpA gene, is the major 3′ exonuclease involved in mRNA turnover; in a ...
Shivani Chhabra, Zachary F. Mandell, Bo Liu, Paul Babitzke, David H. Bechhofer   +4 more
doaj   +1 more source

PNPase degradation dynamic analysis

, 2023
The electrical detecion data and analyized data have been included in this file.
Zhihengyang, Xuefeng Guo
openaire   +1 more source

Polynucleotide Phosphorylase Mediates a New Mechanism of Persister Formation in Escherichia coli

Microbiology Spectrum, 2023
Despite the identification of many genes and pathways involved in the persistence phenomenon in bacteria, the mechanisms of persistence are not well understood.
Nan Wu, Yumeng Zhang, Shanshan Zhang, Youhua Yuan, Shuang Liu, Tao Xu, Peng Cui, Wenhong Zhang, Ying Zhang   +8 more
doaj   +1 more source

Novel Aspects of Polynucleotide Phosphorylase Function in Streptomyces

Antibiotics, 2018
Polynucleotide phosphorylase (PNPase) is a 3′–5′-exoribnuclease that is found in most bacteria and in some eukaryotic organelles. The enzyme plays a key role in RNA decay in these systems.
George H. Jones
doaj   +1 more source

Different csrA Expression Levels in C versus K-12 E. coli Strains Affect Biofilm Formation and Impact the Regulatory Mechanism Presided by the CsrB and CsrC Small RNAs

Microorganisms, 2021
Escherichia coli C is a strong biofilm producer in comparison to E. coli K-12 laboratory strains due to higher expression of the pgaABCD operon encoding the enzymes for the biosynthesis of the extracellular polysaccharide poly-β-1,6-N-acetylglucosamine ...
Thomas Carzaniga, Federica A. Falchi, Francesca Forti, Davide Antoniani, Paolo Landini, Federica Briani   +5 more
doaj   +1 more source

Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability [PDF]

, 2018
R loops are nucleic acid structures comprising an DNA-RNA hybrid and a displaced single-stranded DNA. These structures may occur transiently during transcription, playing essential biological functions. However, persistent R loops may become pathological
Aguilera López, Andrés, Pérez de Camino Cantos, Dolores, Silva, Sonia   +2 more
core   +1 more source

The endoribonucleolytic N-terminal half of Escherichia coli RNase E is evolutionarily conserved in Synechocystis sp. and other bacteria but not the C-terminal half, which is sufficient for degradosome assembly [PDF]

, 1998
Escherichia coli RNase E, an essential single-stranded specific endoribonuclease, is required for both ribosomal RNA processing and the rapid degradation of mRNA.
Jakobsen, J.S., Kaberdin, V.R., Lin-Chao, S., McDowall, K.J., Miczak, A., Von Gabain, A.   +5 more
core   +2 more sources

Polynucleotide phosphorylase is implicated in homologous recombination and DNA repair in Escherichia coli

BMC Microbiology, 2017
Background Polynucleotide phosphorylase (PNPase, encoded by pnp) is generally thought of as an enzyme dedicated to RNA metabolism. The pleiotropic effects of PNPase deficiency is imputed to altered processing and turnover of mRNAs and small RNAs, which ...
Thomas Carzaniga, Giulia Sbarufatti, Federica Briani, Gianni Dehò   +3 more
doaj   +1 more source