Results 81 to 90 of about 4,071 (219)

Phase Separation Regulates Metabolism, Mitochondria, and Diseases

MedComm, Volume 6, Issue 7, July 2025.
Mitochondrion‐related liquid–liquid phase separation. (1) Phase separation mediates the self‐assembly of mitochondrial nucleoids (mt‐nucleoids). (2) Phase segregation mediates the formation of mitochondrial RNA granules (MRGs). (3) Phase separation mediates the formation of mitochondrial degradosomes.
Chuan Gao, Peng Ding, Changqing Zhang, Junjie Gao   +3 more
wiley   +1 more source

Elucidating the molecular physiology of lantibiotic NAI-107 production in Microbispora ATCC-PTA-5024 [PDF]

, 2016
BACKGROUND: The filamentous actinomycete Microbispora ATCC-PTA-5024 produces the lantibiotic NAI-107, which is an antibiotic peptide effective against multidrug-resistant Gram-positive bacteria. In actinomycetes, antibiotic production is often associated
Alduina, Rosa, Arena, Simona, Faddetta, Teresa, Gallo, Giuseppe, Giardina, Anna, Monciardini, Paolo, Palazzotto, Emilia, Puglia, Anna Maria, Renzone, Giovanni, Russo, Alessandro, Sangiorgi, Fabio, Scaloni, Andrea, Sosio, Margherita, Spinelli, Giovanni, Weber, Tilmann   +14 more
core   +4 more sources

Defective Processing of Cytoplasmic and Chloroplast Ribosomal RNA in the Absence of Arabidopsis DXO1

Plant, Cell &Environment, Volume 48, Issue 6, Page 4227-4244, June 2025.
ABSTRACT Decapping 5′‐3′ exoribonucleases from the DXO/Rai1 family are highly conserved among eukaryotes and exhibit diverse enzymatic activities depending on the organism. The biochemical and structural properties of the plant DXO1 differ from the yeast and animal counterparts, which is reflected in the in vivo functions of this enzyme.
Monika Zakrzewska‐Placzek, Anna Golisz‐Mocydlarz, Aleksandra Kwasnik, Michal Krzyszton, Katarzyna Niedzwiecka, Joanna Kufel   +5 more
wiley   +1 more source

Severo Ochoa and the Biomedical Sciences in Spain under Franco, 1959-1975 [PDF]

, 2000
The influence of Severo Ochoa in the establishment of biochemistry and molecular biology in Spain is the central topic of this essay. From the time he was awarded the Nobel Prize in Physiology or Medicine in 1959, Ochoa's links with Spanish scientists ...
Modigell, Michael, Pola, Annalisa, Suery, Michel, Zang, Christoph   +3 more
core   +1 more source

Target recognition by RNase E RNA-binding domain AR2 drives sRNA decay in the absence of PNPase

Proceedings of the National Academy of Sciences, 2022
The C-terminal domain (CTD) of the major endoribonuclease RNase E not only serves as a scaffold for the central RNA decay machinery in gram-negative bacteria but also mediates coupled degradation of small regulatory RNAs (sRNAs) and their cognate target transcripts following RNA chaperone Hfq–facilitated sRNA–mRNA base pairing. Despite the
Dhriti Sinha, Nicholas R. De Lay
openaire   +2 more sources

Estimating the size of the solution space of metabolic networks [PDF]

, 2007
In this work we propose a novel algorithmic strategy that allows for an efficient characterization of the whole set of stable fluxes compatible with the metabolic constraints.
Braunstein, Alfredo, Mulet, Roberto, Pagnani, Andrea   +2 more
core   +4 more sources

Using in silico models to simulate dual perturbation experiments: procedure development and interpretation of outcomes. [PDF]

, 2009
BackgroundA growing number of realistic in silico models of metabolic functions are being formulated and can serve as 'dry lab' platforms to prototype and simulate experiments before they are performed.
Jamshidi, Neema, Palsson, Bernhard O
core   +3 more sources

Looping forward: exploring R‐loop processing and therapeutic potential

FEBS Letters, Volume 599, Issue 2, Page 244-266, January 2025.
R‐loops function as both regulators of gene expression, DNA repair, telomere maintenance or chromosome segregation, and as drivers of genome instability. This dual nature of these structures is coordinated by RNA/DNA/chromatin processing factors that safeguard the genome from detrimental R‐loop‐instigated DNA damage or cellular dysfunction ...
Kalliopi Stratigi, Athanasios Siametis, George A. Garinis   +2 more
wiley   +1 more source

An RNA-seq based comparative approach reveals the transcriptome-wide interplay between 3′-to-5′ exoRNases and RNase Y

Nature Communications, 2020
Bacterial RNA degradation is typically initiated by endoribonucleases and followed by exoribonucleases. Here the authors report the targetome of endoRNase Y in Streptococcus pyogenes, revealing the interplay between RNase Y and 3′-to-5′ exoribonuclease ...
Laura Broglia, Anne-Laure Lécrivain, Thibaud T. Renault, Karin Hahnke, Rina Ahmed-Begrich, Anaïs Le Rhun, Emmanuelle Charpentier   +6 more
doaj   +1 more source

Crystal structure of the S. solfataricus archaeal exosome reveals conformational flexibility in the RNA-binding ring. [PDF]

PLoS ONE, 2010
The exosome complex is an essential RNA 3'-end processing and degradation machinery. In archaeal organisms, the exosome consists of a catalytic ring and an RNA-binding ring, both of which were previously reported to assume three-fold symmetry.Here we ...
Changrui Lu, Fang Ding, Ailong Ke
doaj   +1 more source