Results 101 to 110 of about 6,165 (196)

Podocalyxin is a marker of poor prognosis in colorectal cancer [PDF]

BMC Cancer, 2014
Over two decades ago, a proposal was that two different colorectal cancer (CRC) entities existed, based on tumour location either proximal (right) or distal (left) of the splenic flexure. Proximal and distal tumours exhibit different clinical, epidemiological, and biological characteristics.
Haglund Caj, Boeckelman Camilla, Mustonen Harri, Hagstroem Jaana, Haglund Caj, Boeckelman Camilla, Mustonen Harri, Hagstroem Jaana, Böckelman Camilla   +8 more
openaire   +4 more sources

セイ サイボウ ケイ シュヨウ ニ オケル ポドカリキシン ノ ハツゲン カイセキ [PDF]

, 2009
論文内容要旨学位取得大学:山形大学 ; 報告番号:医博乙第557号 ; 学位の種類: 論文 ; 学位の種別:博士 ...
早津 徳人
core   +1 more source

Co-expression networks in generation of induced pluripotent stem cells. [PDF]

, 2016
We developed an adenoviral vector, in which Yamanaka's four reprogramming factors (RFs) were controlled by individual CMV promoters in a single cassette (Ad-SOcMK). This permitted coordinated expression of RFs (SOX2, OCT3/4, c-MYC and KLF4) in a cell for
Coppola, Giovanni, Dansithong, Warunee, Figueroa, Karla P, Gao, Fuying, Paul, Sharan, Pflieger, Lance, Pulst, Stefan M   +6 more
core   +2 more sources

Counting glomeruli in human kidney specimens using ex vivo MRI without contrast agents

Magnetic Resonance in Medicine, Volume 94, Issue 6, Page 2519-2528, December 2025.
Abstract Purpose The total number of glomeruli is an important indicator of kidney function and susceptibility to disease. Glomeruli, however, are difficult to image using MRI without contrast enhancement. For this reason, previous studies have used cationic ferritin as a contrast agent to detect glomeruli in ex vivo and in vivo perfused kidneys.
Nyoman D. Kurniawan, Aurel J. Amar, Luise A. Cullen‐McEwen, Alexander N. Combes, Raeesah Hayatudin, Andrew J. Kassianos, Jiaxin Du, Sarah E. Gazzard, Helen G. Healy, Wendy E. Hoy, John F. Bertram, David C. Reutens   +11 more
wiley   +1 more source

Trophoblast-induced changes in C-x-C motif chemokine 10 expression contribute to vascular smooth muscle cell dedifferentiation during spiral artery remodeling. [PDF]

, 2013
Objective- During pregnancy, fetal trophoblast disrupt endothelial cell and vascular smooth muscle cell (VSMC) interactions in spiral arteries of the maternal decidua to enable increased nutritional and oxygen delivery to the fetus.
Begum, R, Cartwright, JE, Laing, K, Thilaganathan, B, Wallace, AE, Whitley, GS   +5 more
core   +1 more source

Blockade of cannabinoid CB1 receptors potentiates the anti‐fibrotic effects mediated by SGLT2 inhibition in a mouse model of diabetic nephropathy

British Journal of Pharmacology, Volume 182, Issue 21, Page 5355-5377, November 2025.
Background and purpose Diabetic nephropathy (DN) is a common complication of diabetes. Current treatments include renin‐angiotensin‐aldosterone system (RAAS) blockers and sodium‐glucose co‐transporter 2 (SGLT2) inhibitors. The cannabinoid CB1 receptor is a potential therapeutic target.
Océane Pointeau, Awa Isma Ba, Audrey Geissler, Romain Barbosa, Abhishek Basu, Arif Muhammad, Marina Nivot, Maéva Loriot, Julia Leemput, Patricia Passilly‐Degrace, Sébastien Causse, Laurent Demizieux, Hélène François, Bruno Vergès, Jianmin Duan, Geneviève Gaucher, Michael Harvey, Pascal Degrace, Glenn Crater, Resat Cinar, Tony Jourdan   +20 more
wiley   +1 more source

Role of podocalyxin in astrocytoma: Clinicopathological and in vitro evidence

Oncology Letters, 2013
The present study examined the expression of podocalyxin (PODX) in surgically-resected astrocytomas, associated the levels of PODX expression with the clinicopathological characteristics and survival outcomes of astrocytoma and assessed how PODX affected the viability of astrocytoma cells following the administration of chemotherapeutic agents.
HUANG, TIANXIANG, JIN, XIN, HE, LEI, ZHANG, MINGYU, WU, JUN, WANG, YANJIN, FANG, JIASHENG   +6 more
openaire   +3 more sources

Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels [PDF]

Nature Communications, 2018
Abstract Mutant p53s (mutp53) increase cancer invasiveness by upregulating Rab-coupling protein (RCP) and diacylglycerol kinase-α (DGKα)-dependent endosomal recycling. Here we report that mutp53-expressing tumour cells produce exosomes that mediate intercellular transfer of mutp53’s invasive/migratory gain-of-function by increasing ...
David Novo, Nikki Heath, Louise Mitchell, Giuseppina Caligiuri, Amanda MacFarlane, Dide Reijmer, Laura Charlton, John Knight, Monika Calka, Ewan McGhee, Emmanuel Dornier, David Sumpton, Susan Mason, Arnaud Echard, Kerstin Klinkert, Judith Secklehner, Flore Kruiswijk, Karen Vousden, Iain R. Macpherson, Karen Blyth, Peter Bailey, Huabing Yin, Leo M. Carlin, Jennifer Morton, Sara Zanivan, Jim C. Norman   +25 more
openaire   +7 more sources

Urinary podocyte markers in diabetic kidney disease [PDF]

Kidney Research and Clinical Practice
Podocytes are involved in maintaining kidney function and are a major focus of research on diabetic kidney disease (DKD). Urinary biomarkers derived from podocyte fragments and molecules have been proposed for the diagnosis and monitoring of DKD. Various
Chuanlei Li, Cheuk-Chun Szeto
doaj   +1 more source

Urinary extracellular vesicles and micro-RNA as markers of acute kidney injury after cardiac surgery

Scientific Reports, 2022
We hypothesised that measuring changes in urinary levels of EV and miR will predict the onset of acute kidney injury in cardiac surgery patients. The study was performed in the cohort of the REVAKI-2 trial.
Douglas Miller, Bryony Eagle-Hemming, Sophia Sheikh, Lathishia Joel-David, Adewale Adebayo, Florence Y. Lai, Marius Roman, Tracy Kumar, Hardeep Aujla, Gavin J. Murphy, Marcin J. Woźniak   +10 more
doaj   +1 more source