Results 101 to 110 of about 6,232 (197)
Exploring the Impact of Platelet‐Derived Growth Factor D in Pulmonary Hypertension Development
Pulmonary Circulation, Volume 15, Issue 4, October 2025.ABSTRACT Pulmonary arterial hypertension (PAH) is a life‐threatening condition with no cure, making research into its underlying mechanisms critical. The platelet‐derived growth factor (PDGF) signaling pathway plays a crucial role in vascular remodeling, a key factor in PAH progression.
Philip Tannenberg +11 more
wiley +1 more source
Podocalyxin is a marker of poor prognosis in colorectal cancer [PDF]
BMC Cancer, 2014 Over two decades ago, a proposal was that two different colorectal cancer (CRC) entities existed, based on tumour location either proximal (right) or distal (left) of the splenic flexure. Proximal and distal tumours exhibit different clinical, epidemiological, and biological characteristics.
Haglund Caj +8 more
openaire +4 more sources
Urinary podocyte markers in diabetic kidney disease [PDF]
Kidney Research and Clinical PracticePodocytes are involved in maintaining kidney function and are a major focus of research on diabetic kidney disease (DKD). Urinary biomarkers derived from podocyte fragments and molecules have been proposed for the diagnosis and monitoring of DKD. Various
Chuanlei Li, Cheuk-Chun Szeto
doaj +1 more source
Identification of Cell Surface Proteins as Potential Immunotherapy Targets in 12 Pediatric Cancers [PDF]
, 2012 Technological advances now allow us to rapidly produce CARs and other antibody-derived therapeutics targeting cell surface receptors. To maximize the potential of these new technologies, relevant extracellular targets must be identified.
Crystal L. Mackall +5 more
core +2 more sources
Cell Proliferation, Volume 58, Issue 10, October 2025.RNF187 mediates the polyubiquitination and subsequent degradation of WDR77, reduces H4R3me2s catalysed by the WDR77/PRMT5 complex, and derepresses the transcription of EGR1, thereby promoting the proliferation and migration of human SSCs. ABSTRACT The E3 ubiquitin ligase RNF187, also known as RING domain AP1 coactivator‐1, is a member of the RING ...
Haoyue Hu +12 more
wiley +1 more source
Polarised VEGFA Signalling at Vascular Blood–Neural Barriers [PDF]
, 2018 At blood–neural barriers, endothelial VEGFA signalling is highly polarised, with entirely different responses being triggered by luminal or abluminal stimulation. These recent findings were made in a field which is still in its mechanistic infancy. For a
Dragoni, S, Turowski, P
core +2 more sources
Advanced Biology, Volume 9, Issue 9, September 2025.The glomerular filtration barrier (GFB) is the first step of blood filtration by the kidneys. The concerning increase of kidney diseases makes the development of new models essential. In this context, microphysiological glomerular filtration barriers focus on closely reproducing the physiological architecture of the in vivo GFB: podocytes, glomerular ...
Manon Miran +5 more
wiley +1 more source
Role of podocalyxin in astrocytoma: Clinicopathological and in vitro evidence
Oncology Letters, 2013 The present study examined the expression of podocalyxin (PODX) in surgically-resected astrocytomas, associated the levels of PODX expression with the clinicopathological characteristics and survival outcomes of astrocytoma and assessed how PODX affected the viability of astrocytoma cells following the administration of chemotherapeutic agents.
HUANG, TIANXIANG +6 more
openaire +3 more sources
Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels [PDF]
Nature Communications, 2018 Abstract Mutant p53s (mutp53) increase cancer invasiveness by upregulating Rab-coupling protein (RCP) and diacylglycerol kinase-α (DGKα)-dependent endosomal recycling. Here we report that mutp53-expressing tumour cells produce exosomes that mediate intercellular transfer of mutp53’s invasive/migratory gain-of-function by increasing ...
David Novo +25 more
openaire +7 more sources
Glycoprotein hyposialylation gives rise to a nephrotic-like syndrome that is prevented by sialic acid administration in GNE V572L point-mutant mice. [PDF]
PLoS ONE, 2012 Mutations in the key enzyme of sialic acid biosynthesis, UDP-N-acetylglucosamine 2-epimerase/N-acetyl-mannosamine kinase, result in distal myopathy with rimmed vacuoles (DMRV)/hereditary inclusion body myopathy (HIBM) in humans.
Mitutoshi Ito +7 more
doaj +1 more source