Results 111 to 120 of about 6,165 (196)
Identification of Cell Surface Proteins as Potential Immunotherapy Targets in 12 Pediatric Cancers [PDF]
, 2012 Technological advances now allow us to rapidly produce CARs and other antibody-derived therapeutics targeting cell surface receptors. To maximize the potential of these new technologies, relevant extracellular targets must be identified.
Crystal L. Mackall +5 more
core +2 more sources
Across Barriers: Blood–Brain and Gut Barrier Signaling in Psychiatric Disorders
Journal of Neurochemistry, Volume 169, Issue 11, November 2025.Biological barrier dysfunction in mood and anxiety disorders. Chronic stress and inflammatory bowel disease converge on systemic inflammation that disrupts the intestinal and blood–brain barriers. Loss of barrier integrity promotes bidirectional gut–brain communication disturbances, heightened neuroimmune activation, and dysregulated signaling pathways,
Luisa Bandeira Binder +5 more
wiley +1 more source
Polarised VEGFA Signalling at Vascular Blood–Neural Barriers [PDF]
, 2018 At blood–neural barriers, endothelial VEGFA signalling is highly polarised, with entirely different responses being triggered by luminal or abluminal stimulation. These recent findings were made in a field which is still in its mechanistic infancy. For a
Dragoni, S, Turowski, P
core +2 more sources
Exploring the Impact of Platelet‐Derived Growth Factor D in Pulmonary Hypertension Development
Pulmonary Circulation, Volume 15, Issue 4, October 2025.ABSTRACT Pulmonary arterial hypertension (PAH) is a life‐threatening condition with no cure, making research into its underlying mechanisms critical. The platelet‐derived growth factor (PDGF) signaling pathway plays a crucial role in vascular remodeling, a key factor in PAH progression.
Philip Tannenberg +11 more
wiley +1 more source
A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis [PDF]
, 2015 During angiogenesis, Rho GTPases influence endothelial cell migration and cell-cell adhesion; however it is not known whether they control formation of vessel lumens, which are essential for blood flow.
A Nishikimi +52 more
core +4 more sources
Cell Proliferation, Volume 58, Issue 10, October 2025.RNF187 mediates the polyubiquitination and subsequent degradation of WDR77, reduces H4R3me2s catalysed by the WDR77/PRMT5 complex, and derepresses the transcription of EGR1, thereby promoting the proliferation and migration of human SSCs. ABSTRACT The E3 ubiquitin ligase RNF187, also known as RING domain AP1 coactivator‐1, is a member of the RING ...
Haoyue Hu +12 more
wiley +1 more source
Revista CientíficaIschemia–reperfusion injury causes oxidative stress and inflammation, leading to skeletal muscle damage. This study investigates the role of N–acetylcysteine in modulating oxidative stress and inflammatory biomarkers specifically Podocalyxin and ...
Emel Sabaz Karakeci +1 more
doaj +1 more source
The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier [PDF]
, 2017 Podocytes form the outer part of the glomerular filter, where they have to withstand enormous transcapillary filtration forces driving glomerular filtration.
Abe, Takaya +21 more
core +1 more source
Advanced Biology, Volume 9, Issue 9, September 2025.The glomerular filtration barrier (GFB) is the first step of blood filtration by the kidneys. The concerning increase of kidney diseases makes the development of new models essential. In this context, microphysiological glomerular filtration barriers focus on closely reproducing the physiological architecture of the in vivo GFB: podocytes, glomerular ...
Manon Miran +5 more
wiley +1 more source
ARHGDIA mutations cause nephrotic syndrome via defective RHO GTPase signaling [PDF]
, 2013 Nephrotic syndrome (NS) is divided into steroid-sensitive (SSNS) and -resistant (SRNS) variants. SRNS causes end-stage kidney disease, which cannot be cured.
Antignac +33 more
core +2 more sources