Intercepting the complement amplification loop through podocyte MC5R signaling ameliorates membranous nephropathy. [PDF]
Mol TherLiu J +5 more
europepmc +1 more source
Large extracellular vesicles (microvesicles) in diabetic nephropathy: a systematic review of preclinical studies. [PDF]
Front PharmacolGhanem SK +3 more
europepmc +1 more source
Podocalyxin regulates pronephric glomerular development in zebrafish [PDF]
Physiological Reports, 2013 Vertebrate glomerular podocytes possess a highly sialylated transmembrane glycoprotein, Podocalyxin. In mammals, the sialic acid of Podocalyxin plays a crucial role in the formation of the characteristic podocyte architecture required for glomerular filtration. We examined the function of Podocalyxin in the developing zebrafish pronephros by disrupting
Koichiro Ichimura, Tomoko Obara
exaly +3 more sources
Urinary podocalyxin is an early marker for podocyte injury in patients with diabetes: establishment of a highly sensitive ELISA to detect urinary podocalyxin [PDF]
Diabetologia, 2012 Nephropathy, a major complication of diabetes, is the leading cause of end-stage renal disease. Recent studies have demonstrated that podocyte injury is involved in the onset of and progression to renal insufficiency. Here, we describe a novel, highly sensitive ELISA for detecting urinary podocalyxin, a glycoconjugate on the podocyte apical surface ...
Y Tomino, Kexiang Yan, Yamagata K
exaly +3 more sources
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Podocalyxin expression in malignant astrocytic tumors
Biochemical and Biophysical Research Communications, 2008Podocalyxin is an anti-adhesive mucin-like transmembrane sialoglycoprotein that has been implicated in the development of aggressive forms of cancer. Podocalyxin is also known as keratan sulfate (KS) proteoglycan. Recently, we revealed that highly sulfated KS or another mucin-like transmembrane sialoglycoprotein podoplanin/aggrus is upregulated in ...
Norihito, Hayatsu +6 more
openaire +2 more sources
Ventricular enlargement associated with the panneural ablation of the podocalyxin gene
Molecular and Cellular Neurosciences, 2010 Podocalyxin (Podxl) is a type I membrane mucin-protein of the CD34 family abundantly expressed in kidney epithelial cells (podocytes) where it plays a crucial functional role. Podxl is also expressed in tissues other than kidney, like in brain, but its function is ignored.
Sonia Alonso-Martin +2 more
exaly +4 more sources
Podocalyxin is expressed in normal and leukemic monocytes
Blood Cells, Molecules, and Diseases, 2006We have investigated the expression of podocalyxin in primary cultures of leukemic blast cells from 73 patients with acute myeloid leukemia. Podocalyxin was expressed at moderate levels in 15 patients and at high levels in 13 patients. The analysis of membrane markers showed that Podocalyxin expression in leukemic blasts was associated with a monocytic
Roberta Riccioni +12 more
openaire +5 more sources
The role of serum podocalyxin levels in recurrent pregnancy loss
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2021To measure serum levels of podocalyxin (PODXL) in recurrent miscarriages as a marker of vascular endothelial dysfunction.In this case-control study, women who were hospitalized for singleton first-trimester pregnancy terminations due to missed abortion, anembryonic pregnancy, and inevitable abortion were included.
Ayçağ, Yorgancı +5 more
openaire +2 more sources
The role of Podocalyxin in colorectal cancer
2023Abstract not currently available.
openaire +2 more sources