Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression [PDF]
, 2012 Endothelial Wnt/β-catenin signaling is necessary for angiogenesis of the central nervous system and blood–brain barrier (BBB) differentiation, but its relevance for glioma vascularization is unknown. In this study, we show that doxycycline-dependent Wnt1
Abramsson +79 more
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Mechanisms by which heme oxygenase rescue renal dysfunction in obesity
Redox Biology, 2014 Obesity and excessive inflammation/oxidative stress are pathophysiological forces associated with kidney dysfunction. Although we recently showed that heme-oxygenase (HO) improves renal functions, the mechanisms are largely unclear. Moreover, the effects
Joseph Fomusi Ndisang, Shuchita Tiwari
doaj +1 more source
Peutz-Jeghers LKB1 mutants fail to activate GSK-3β, preventing it from inhibiting Wnt signaling [PDF]
, 2018 Peutz-Jeghers syndrome (PJS) is caused by germline mutations in the LKB1 gene, which encodes a serine-threonine kinase that regulates cell proliferation and polarity. This autosomal dominant disorder is characterized by mucocutaneous melanin pigmentation,
Antonarakis, Stylianos +2 more
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Identification and characterization of kidney glomerulus-associated genes and proteins [PDF]
, 2012 The kidney glomerulus is a micro-organ comprised of a molecular filtration barrier that prevents the loss of blood proteins into the primary filtrate. This function is dependent on the coordination of its three constituent layers: the endothelium, the ...
Perisic, Ljubica
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miR-199b, a novel tumor suppressor miRNA in acute myeloid leukemia with prognostic implications [PDF]
, 2016 Additional file 1: Figure S1. miR-199b-5p targets HIF-1 alpha. Transcript levels of three predicted targets of miR-199b were tested via RT-qPCR in miR-199b silenced CD34 cells and HIF-1a levels were significantly increased by anti-miR ...
Amanda J. Favreau +3 more
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Circulating Podocalyxin, Tumstatin/Col-IVα3 and Chitinase 1: New Culprits in Vitiligo Occurrence
Dermatology Practical & ConceptualIntroductionː The roles of anti-adhesive podocalyxin (PODXL), ant-angiogenetic tumstatin/Col-IVα3 and neuroinflammation and innate immunity modulator Chitinase 1 (CHIT-1) in the etiology of vitiligo have not been studied yet.
Şule Gençoğlu
doaj +1 more source
Role of podocalyxin in hematopoiesis and cell migration
, 2008 CD34 and its relatives, Podocalyxin and Endoglycan, comprise of a family of surface sialomucins expressed by hematopoietic stem/progenitor cells, and vascular endothelia. Recent data suggest that they serve as either pro- or anti-adhesion molecules depending on their cellular context and their post-translational modifications.
openaire +1 more source
Spatiotemporal expression patterns of sialoglycoconjugates during nephron morphogenesis and their regional and cell type-specific distribution in adult rat kidney [PDF]
, 2018 The expression of α2,6- and α2,3-linked sialic acids on N-glycans was studied in embryonic, postnatal, and adult rat kidney. Histochemistry and blotting using Polyporus squamosus and Sambucus nigra lectins for α2,6-linked sialic acids and the Maackia ...
Goldstein, Irwin +5 more
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