Joyeux anniversaire, CD34 ! [PDF]
, 2005 Vingt ans après la première description de l’antigène CD34, cette molécule continue de susciter la curiosité des scientifiques, qui cherchent toujours à élucider la fonction exacte de ce qui est rapidement apparu comme un « marqueur de la cellule souche ...
Chabannon, Christian
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Peutz-Jeghers LKB1 mutants fail to activate GSK-3β, preventing it from inhibiting Wnt signaling [PDF]
, 2018 Peutz-Jeghers syndrome (PJS) is caused by germline mutations in the LKB1 gene, which encodes a serine-threonine kinase that regulates cell proliferation and polarity. This autosomal dominant disorder is characterized by mucocutaneous melanin pigmentation,
Antonarakis, Stylianos +2 more
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Identification and characterization of kidney glomerulus-associated genes and proteins [PDF]
, 2012 The kidney glomerulus is a micro-organ comprised of a molecular filtration barrier that prevents the loss of blood proteins into the primary filtrate. This function is dependent on the coordination of its three constituent layers: the endothelium, the ...
Perisic, Ljubica
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GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. [PDF]
, 2014 Progressive liver fibrosis is characterized by the deposition of collagen by activated hepatic stellate cells (HSCs). Activation of HSCs is a multiple receptor-driven process in which profibrotic signals are enhanced and antifibrotic pathways are ...
Aroonsakool, Nakon +13 more
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Erk5 is a mediator to TGFβ1-induced loss of phenotype and function in human podocytes. [PDF]
, 2014 Background: Podocytes are highly specialized cells integral to the normal functioning kidney, however, in diabetic nephropathy injury occurs leading to a compromised phenotype and podocyte dysfunction which critically produces podocyte loss with ...
Binder +39 more
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The Role of Th17/IL-17 in the Pathogenesis of Primary Nephrotic Syndrome in Children
Kidney & Blood Pressure Research, 2013 Background: This work aims to explore the role of Th17 and IL-17 signaling in the pathogenesis of primary nephrotic syndrome (PNS) in children and podocyte injury, children with PNS were divided into minimal change nephrotic syndrome (MCNS) and non ...
Li Wang +6 more
doaj +1 more source
Circulating Podocalyxin, Tumstatin/Col-IVα3 and Chitinase 1: New Culprits in Vitiligo Occurrence
Dermatology Practical & ConceptualIntroductionː The roles of anti-adhesive podocalyxin (PODXL), ant-angiogenetic tumstatin/Col-IVα3 and neuroinflammation and innate immunity modulator Chitinase 1 (CHIT-1) in the etiology of vitiligo have not been studied yet.
Şule Gençoğlu
doaj +1 more source
Role of podocalyxin in hematopoiesis and cell migration
, 2008 CD34 and its relatives, Podocalyxin and Endoglycan, comprise of a family of surface sialomucins expressed by hematopoietic stem/progenitor cells, and vascular endothelia. Recent data suggest that they serve as either pro- or anti-adhesion molecules depending on their cellular context and their post-translational modifications.
openaire +1 more source
Spatiotemporal expression patterns of sialoglycoconjugates during nephron morphogenesis and their regional and cell type-specific distribution in adult rat kidney [PDF]
, 2018 The expression of α2,6- and α2,3-linked sialic acids on N-glycans was studied in embryonic, postnatal, and adult rat kidney. Histochemistry and blotting using Polyporus squamosus and Sambucus nigra lectins for α2,6-linked sialic acids and the Maackia ...
Goldstein, Irwin +5 more
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