Results 161 to 170 of about 5,352 (196)
In situ evaluation of podocin in normal and glomerular diseases [PDF]
Kidney International, 2003 Mutations of the NPHS2 gene are responsible for autosomal-recessive steroid-resistant nephrotic syndrome. Its product, podocin, faces the slit diaphragm area with its two ends in the cytoplasm of foot processes.We generated rabbit polyclonal antibodies against conjugated peptides from human podocin N- and C-termini, and studied podocin and synaptopodin
Hitoshi Nakazato, Ken-Ichi Iyama
exaly +4 more sources
C-terminal oligomerization of podocin mediates interallelic interactions [PDF]
Biochimica Et Biophysica Acta - Molecular Basis of Disease, 2018 Interallelic interactions of membrane proteins are not taken into account while evaluating the pathogenicity of sequence variants in autosomal recessive disorders. Podocin, a membrane-anchored component of the slit diaphragm, is encoded by NPHS2, the major gene mutated in hereditary podocytopathies.
Pal Stráner +2 more
exaly +5 more sources
Nephrin and podocin dissociate at the onset of proteinuria in experimental membranous nephropathy [PDF]
Kidney International, 2005 The slit diaphragm plays a critical role in maintaining the barrier function of the glomerular capillary wall. The pathogenic mechanism of proteinuria in membranous nephropathy remains uncertain. This study was undertaken to analyze the pathogenic role of slit diaphragm in proteinuria in experimental membranous nephropathy.The expression and the ...
Takeshi Nakatsue +2 more
exaly +4 more sources
New perspectives on the renal slit diaphragm protein podocin [PDF]
Modern Pathology, 2011 Podocin is a critical component of the glomerular filtration barrier, its mutations causing recessive steroid-resistant nephrotic syndrome. A GenBank analysis of the human podocin (NPHS2) gene resulted in the possible existence of a new splice variant of podocin in the kidney, missing the in-frame of exon 5, encoding the prohibitin homology domain ...
Manfred Relle +2 more
exaly +3 more sources
Effect of the Knockdown of Podocin mRNA on Nephrin and α-Actinin in Mouse Podocyte
Experimental Biology and Medicine, 2004 Recently, the novel podocyte proteins podocin, nephrin, and α-actinin-4 have been identified in three congenital/family nephrotic syndromes, respectively.
Qingfeng Fan, Na Guan
exaly +2 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Imaging of Podocytic Proteins Nephrin, Actin, and Podocin with Expansion Microscopy
Journal of Visualized Experiments, 2021Disruption of the glomerular filter composed of the glomerular endothelium, glomerular basement membrane and podocytes, results in albuminuria. Podocyte foot processes contain actin bundles that bind to cytoskeletal adaptor proteins such as podocin. Those adaptor proteins, such as podocin, link the backbone of the glomerular slit diaphragm, such as ...
Eva, Königshausen +3 more
openaire +2 more sources
Nephrin and Podocin Expression Around the Onset of Puromycin Aminonucleoside Nephrosis
Journal of Pharmacological Sciences, 2005 Decreased expression levels of the glomerular slit membrane proteins, nephrin and podocin, have been reported after the onset of puromycin aminonucleoside (PA) nephrosis. We examined nephrin and podocin expressions prior to the onset of proteinuria of PA nephrosis to elucidate the proteinuria induction mechanism of PA.
Makoto Hosoyamada +2 more
exaly +4 more sources
Endoplasmic reticulum–retained podocin mutants are massively degraded by the proteasome [PDF]
Journal of Biological Chemistry, 2018 Podocin is a key component of the slit diaphragm in the glomerular filtration barrier, and mutations in the podocin-encoding gene NPHS2 are a common cause of hereditary steroid-resistant nephrotic syndrome. A mutant allele encoding podocin with a p.R138Q amino acid substitution is the most frequent pathogenic variant in European and North American ...
Fabien Nevo +2 more
exaly +4 more sources
Intracellular mislocalization of mutant podocin and correction by chemical chaperones
Histochemistry and Cell Biology, 2003The NPHS2 gene encoding the podocin protein was causally linked to the autosomal recessive type of steroid-resistant nephrotic syndrome. In this study, we investigated the consequence of the R138Q mutation of podocin, one of the most common missense mutations in the NPHS2 gene, by examining the expression of the wild-type and R138Q mutant podocins in ...
Teiko, Ohashi +4 more
openaire +2 more sources