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The transcriptional regulation of Podocin (NPHS2) by Lmx1b and a promoter single nucleotide polymorphism [PDF]
Cellular and Molecular Biology Letters, 2009 AbstractPodocin (NPHS2) is a component of the glomerular slit membrane with major regulatory functions in the renal permeability of proteins. A loss of podocin and a decrease in its resynthesis can influence the outcome of renal diseases with nephrotic syndrome, such as minimal change glomerulonephritis, focal segmental glomerulosclerosis (FSGS) and ...
Rolf A K Stahl
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NEPH1 defines a novel family of podocin‐interacting proteins
The FASEB Journal, 2002ABSTRACT Mutations of NPHS1 or NPHS2, the genes encoding for the glomerular podocyte proteins nephrin and podocin, cause steroid‐resistant proteinuria. In addition, mice lacking NEPH1 develop a nephrotic syndrome that resembles NPHS mutations, suggesting that all three proteins are essential for the integrity of ...
Sellin, Lorenz +5 more
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Expression of nephrin, podocin, ?-actinin, and WT1 in children with nephrotic syndrome
Pediatric Nephrology, 2003Recently, nephrin, podocin, alpha-actinin, and WT1, which are located at the slit diaphragm and expressed by the podocyte, were found to be causative in congenital/familial nephrotic syndrome (NS), but their role in acquired NS remains unclear. We studied their expression in NS with the aim of disclosing their possible role in the development of ...
Na Guan, Guan Na, Jingjing Zhang
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ANGPTL4 promotes nephrotic syndrome by downregulating podocyte expression of ACTN4 and podocin
Biochemical and Biophysical Research Communications, 2023lipopolysaccharide (LPS) can induce nephrotic syndrome-like features such as massive proteinuria, hyperlipidemia, and fusion of glomerular podocytes with foot processes (FPs) in mice. Angiopoietin-like protein 4 (ANGPTL4) neutralized the negative charge of glomerular basement membrane charge and aggravated renal injury.
Yue, Li +8 more
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Electronic microarray screening of podocin mutations: a single-center study
International Urology and Nephrology, 2008Because of resistance to immunosuppressants in nephrotic syndrome and reduction of proteinuria relapses following renal transplantation, it seems that new horizons have arisen from mutational screening of the podocin gene. The aim of this study was to assess electronic microarray screening of the podocin mutation.Twelve previously identified podocin ...
Onur, Sakallioglu +6 more
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Mutated podocin manifesting as CMV-associated congenital nephrotic syndrome
Pediatric Nephrology, 2003We report a girl with congenital nephrotic syndrome (CNS) associated with cytomegalovirus (CMV) infection and histological findings on renal biopsy that suggested a causal relationship between the two. She was subsequently found to be homozygous for a nonsense mutation in the NPHS2 gene encoding podocin (R138X), which is the true cause of her NS. Based
Yaacov, Frishberg +5 more
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Pinpointing Podocin Trafficking Defects in Kidney Organoids
Journal of the American Society of Nephrology, 2023Pinyuan, Tian, Rachel, Lennon
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Autocrine VEGF-A system in podocytes regulates podocin and its interaction with CD2AP
American Journal of Physiology-Renal Physiology, 2006Vascular endothelial growth factor (VEGF-A) signaling is required for endothelial cell differentiation, vasculogenesis, angiogenesis, and vascular patterning. During kidney morphogenesis, podocyte VEGF-A guides endothelial cells toward developing glomeruli.
Fangxia, Guan +4 more
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Crystallization of podocin, associated with nephrotic syndrome
Acta Crystallographica Section A Foundations and Advances, 2023K. Ando, H. Yokoyama
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