Results 101 to 110 of about 28,951 (302)

Activation of USP30 Disrupts Endothelial Cell Function and Aggravates Acute Lung Injury Through Regulating the S‐Adenosylmethionine Cycle

Advanced Science, EarlyView.
USP30 deubiquitinates and stabilizes MAT2A, thereby regulating DNA methylation and miRNA expression, which ultimately leads to disruption of lung endothelial barrier and inflammation. Abstract Microvascular dysfunction is a key contributor to the development of acute inflammatory diseases, characterized by heightened vascular hyperpermeability and ...
Baoyinna Baoyinna, Jinshan He, Jiaxing Miao, Nargis Shaheen, Boyu Xia, Cankun Wang, Qin Ma, Matthew C Bernier, Bryan A Whitson, Nuo Sun, Jing Zhao, Yutong Zhao   +11 more
wiley   +1 more source

Tmem30a protects against podocyte injury through suppression of pyroptosis

iScience
Summary: Podocytopathies, such as focal segmental glomerulosclerosis (FSGS), are characterized by podocyte injury and can easily progress to end-stage kidney disease. However, the mechanisms underlying podocyte injury remain unclear. We observed podocyte
Yanpei Hou, Sipei Chen, Lei Peng, Liming Huang, Huijian Zhang, Ping Zhang, Min Yu, Lin Xiong, Xiang Zhong, Wenjing Liu, Xianjun Zhu, Li Wang, Yi Li, Guisen Li   +13 more
doaj   +1 more source

Myeloid-Derived Suppressor Cells Induce Podocyte Injury Through Increasing Reactive Oxygen Species in Lupus Nephritis

Frontiers in Immunology, 2018
The expansion of myeloid-derived suppressor cells (MDSCs) has been documented in murine models and patients with lupus nephritis (LN), but the exact role of MDSCs in this process remains largely unknown.
Dongya Zhang, Jingjing Xu, Jing Ren, Liang Ding, Guoping Shi, Dan Li, Huan Dou, Huan Dou, Yayi Hou, Yayi Hou   +9 more
doaj   +1 more source

Asparaginyl endopeptidase protects against podocyte injury in diabetic nephropathy through cleaving cofilin-1

Cell Death and Disease, 2022
Podocyte injury and loss are critical events in diabetic nephropathy (DN); however, the underlying molecular mechanisms remain unclear. Here, we demonstrate that asparaginyl endopeptidase (AEP) protects against podocyte injury through modulating the ...
Chuntao Lei, Mengran Li, Yang Qiu, Yaru Xie, Zhe Hao, Xingjie Yin, Zhentao Zhang, Hua Su, Linlin Yang, Jihong Lin, Hans-Peter Hammes, Chun Zhang   +11 more
doaj   +1 more source

Parp1 protects against Aag-dependent alkylation-induced nephrotoxicity in a sex-dependent manner [PDF]

, 2015
ephrotoxicity is a common toxic side-effect of chemotherapeutic alkylating agents. Although the base excision repair (BER) pathway is essential in repairing DNA alkylation damage, under certain conditions the initiation of BER produces toxic repair ...
Ashrafi, Bahn, Benzing, Botto, Bruno, Burckhardt, Caricchio, Elliot, Fukatsu, Garibotto, Goldschmeding, Golestaneh, Hellmark, Huang, Hurn, Karl, Kibbe, Koren, Koya, LeBlanc, Manabe, Matsumura, Matsumura, Moeckel, Nardulli, Nishinakagawa, Obrosova, Oh, Ortiz, Pacher, Padanilam, Padanilam, Padanilam, Patrick, Paz-Elizur, Pioli, Ponticelli, Povey, Price, Reckelhoff, Roth, Samson, Samson, Samson, Samson, Schwartz, Shankland, Silbiger, Silbiger, Skinner, Suszták, Suzuki, Szabo, Virág, Wagner, Warrens, Weber, Wiggins, Wilson, Wilson, Woolf, Yang, Zagonel, Zucker   +63 more
core   +2 more sources

Metabolite‐Guided Acetylation Therapy: Astragaloside IV Reverses Diabetic Nephropathy via Gna13‐Driven Purine Metabolic Reprogramming

Food Frontiers, EarlyView.
This study unveils how ASIV reverses diabetic nephropathy by restoring Gna13‐K363 acetylation and reprogramming purine metabolism. Using spatial metabolomics and acetylproteomics, we identified zonation‐specific purine dysregulation in diabetic kidneys, with ASIV normalizing metabolite distribution (hypoxanthine, cAMP, guanine) and targeting Gna13 ...
Shi Qiu, Sifan Guo, Dandan Xie, Zhibo Wang, Ying Cai, Xian Wang, Qiang Yang, Chunsheng Lin, Hong Yao, Qiqi Zhao, Yu Guan, Songqi Tang, Yiqiang Xie, Aihua Zhang   +13 more
wiley   +1 more source

Disruption of Myosin 1e Promotes Podocyte Injury [PDF]

Journal of the American Society of Nephrology, 2009
Myosin 1e (Myo1e) is one of two Src homology 3 domain-containing "long-tailed" type I myosins in vertebrates, whose functions in health and disease are incompletely understood. Here, we demonstrate that Myo1e localizes to podocytes in the kidney. We generated Myo1e-knockout mice and found that they exhibit proteinuria, signs of chronic renal injury ...
Sangwon V. Kim, Michael Kashgarian, Mira Krendel, Tim Willinger, Mark S. Mooseker, Richard A. Flavell, Tong Wang   +6 more
openaire   +2 more sources

Medicine‐Food Plant Polysaccharides Modulate Diabetes and Diabetic Complications Through Maintaining Gut Function: A Review

Food Frontiers, EarlyView.
Polysaccharides derived from medicine‐food plants restore intestinal barrier integrity and microbiota balance while modulating short‐chain fatty acid levels. These modifications significantly alleviate diabetes and its complications, including nephropathy, retinopathy, cardiovascular disease, and neuropathy.
Yi Long, Wanglong Yu, Pingping Yang, Minxuan Xu, Jitao Ling, Yuting Wu, Xiao Liu, Liu Ouyang, Yan Xiong, Jianping Liu, Yiming Gan, Jing Zhang, Peng Yu, Deju Zhang   +13 more
wiley   +1 more source

A case report of adrenocorticotropic hormone to treat recurrent focal segmental glomerular sclerosis post-transplantation and biomarker monitoring [PDF]

, 2015
Background: Recurrent focal segmental glomerular sclerosis (rFSGS) in renal transplant recipients (RTR) is difficult to predict and treat. Early rFSGS is likely from circulating factors and preformed antibodies.
Anwar, Siddiq, Ashraf, Muhammad, Brennan, Daniel C, Culiberk, Nancy, Larson, Derek S, Liapis, Helen, Naimi, Nimi, Reiser, Jochen, Wei, Changli   +8 more
core   +10 more sources

Glomerular Function and Structure in Living Donors: Lessons from Single Nephron Studies [PDF]

, 2016
One third of the kidney transplants performed in the USA come from living kidney donors. The long-term outcome of healthy individuals who donate kidneys is mostly excellent, although recent studies have suggested that living donation is associated with a
Bryan D. Myers, Colin R. Lenihan, Jane C. Tan   +2 more
core   +1 more source