Results 141 to 150 of about 28,951 (302)

Blockade of cannabinoid CB1 receptors potentiates the anti‐fibrotic effects mediated by SGLT2 inhibition in a mouse model of diabetic nephropathy

British Journal of Pharmacology, Volume 182, Issue 21, Page 5355-5377, November 2025.
Background and purpose Diabetic nephropathy (DN) is a common complication of diabetes. Current treatments include renin‐angiotensin‐aldosterone system (RAAS) blockers and sodium‐glucose co‐transporter 2 (SGLT2) inhibitors. The cannabinoid CB1 receptor is a potential therapeutic target.
Océane Pointeau, Awa Isma Ba, Audrey Geissler, Romain Barbosa, Abhishek Basu, Arif Muhammad, Marina Nivot, Maéva Loriot, Julia Leemput, Patricia Passilly‐Degrace, Sébastien Causse, Laurent Demizieux, Hélène François, Bruno Vergès, Jianmin Duan, Geneviève Gaucher, Michael Harvey, Pascal Degrace, Glenn Crater, Resat Cinar, Tony Jourdan   +20 more
wiley   +1 more source

Histidine‐Containing Dipeptides in Obesity and Cardiometabolic Health: A Systematic Scoping Review

Obesity Reviews, Volume 26, Issue 11, November 2025.
ABSTRACT Background Histidine‐containing dipeptides (HCDs) have been reported to have anti‐inflammatory and antidiabetic properties. Yet, no previous reviews have examined the impact of HCDs on Type 2 diabetes (T2D) risk factors (e.g., obesity) and progression (e.g., microvascular and macrovascular complications).
Saeede Saadati, Robel Hussen Kabthymer, Giancarlo Aldini, Thilini R. Thrimawithana, Julie E. Stevens, Kathy Ngyuen, Arshad Majid, Simon M. Bell, Jack Feehan, Aya Mousa, Barbora de Courten   +10 more
wiley   +1 more source

Effect of N-acetyl-seryl-aspartyl-lysyl-proline on high glucose-induced podocyte injury

Linchuang shenzangbing zazhi, 2018
Objective To investigate the effect of N-acetyl-seryl-aspartyl-lysyl-proline(AcSDKP) on podocyte injury induced by high glucose and its possible mechanisms.Methods The conditionally immortalized mouse podocytes were treated by high glucose with or ...
ZHA Dong-qing, GAO Ping, WU Xiao-yan
doaj  

R-roscovitine (CYC202) alleviates renal cell proliferation in nephritis without aggravating podocyte injury [PDF]

, 2005
M Milovanceva-Popovska, Uta Kunter, Tammo Ostendorf, Arndt T. Petermann, Song Rong, Frank Eitner, Dontscho Kerjaschki, Anna Barnett, Jürgen Floege   +8 more
openalex   +1 more source

Cdk5 Contributes to Diabetic Islet β Cell and Kidney Injury by Impairing Autophagy

The FASEB Journal, Volume 39, Issue 20, 31 October 2025.
Over‐activation of cyclin‐dependent kinase 5 (Cdk5) is involved in the development of diabetes and its complications. Mechanistically, Cdk5 expression was upregulated in diabetic mice, which induced attenuated autophagy and increased apoptosis of islet β cells, as well as decreased insulin secretion.
Yuejia Tao, Li Wang, Yipeng Liu, Yong Wei, Ruixue Wang, Sha Sha, Shanshan Zheng, Shijie Hou, Shunyao Liu   +8 more
wiley   +1 more source

Risedronate Attenuates Podocyte Injury in Phosphate Transporter-Overexpressing Rats

International Journal of Endocrinology, 2019
Osteoporosis patients with chronic kidney disease (CKD) are becoming common in our superaging society. Renal dysfunction causes phosphorus accumulation in the circulating plasma and leads to the development of CKD-mineral bone disorder (MBD).
Yohei Asada, Takeshi Takayanagi, Tsukasa Kawakami, Eisuke Tomatsu, Atsushi Masuda, Yasumasa Yoshino, Sahoko Sekiguchi-Ueda, Megumi Shibata, Tomihiko Ide, Hajime Niimi, Eishin Yaoita, Yusuke Seino, Yoshihisa Sugimura, Atsushi Suzuki   +13 more
doaj   +1 more source

Commentary on: Inhibition of LINC00707/miR‐223‐3p/FKBP5 axis has a protective effect on diabetic kidney disease

Journal of Diabetes Investigation, EarlyView.
Yirui Zhao, Fengyue Zhang
wiley   +1 more source

Tunneling Nanotube‐Mediated Transcellular Autophagy Alleviates Cadmium Induced Hepatocyte Injury

Advanced Science, Volume 12, Issue 37, October 6, 2025.
ROS accumulation is an important upstream signal for activating transcellular autophagy. Incomplete autophagy and TNT formation are necessary conditions for activating transcellular autophagy, and the disruption of the autophagic fusion mechanism is a trigger for activating transcellular autophagy.
Tao Wang, Li Wang, Jian Sun, Yan Chen, Waseem Ali, Yonggang Ma, Ruilong Song, Xishuai Tong, Jiaqiao Zhu, Yan Yuan, Jianhong Gu, Jianchun Bian, Zongping Liu, Hui Zou   +13 more
wiley   +1 more source

Podocyte injury induced by mesangial-derived cytokines in IgA nephropathy [PDF]

, 2008
K.N. Lai, Joseph C.K. Leung, Loretta Y.Y. Chan, Moin A. Saleem, P. W. Mathieson, Ka Ying Tam, Jing Xiao, F M Lai, Sydney C.W. Tang   +8 more
openalex   +1 more source

Identification and characterization of novel glomerulus-associated genes and proteins [PDF]

, 2010
The kidney is responsible for sieving the circulating blood to eliminate water-soluble waste products and potentially toxic substances from the body. The filtration step occurs in specialized filtration units called glomeruli.
Xiao, Zhijie
core