Results 1 to 10 of about 68,048 (352)
Growth hormone induces mitotic catastrophe of glomerular podocytes and contributes to proteinuria [PDF]
Cell Death and Disease, 2021 Glomerular podocytes are integral members of the glomerular filtration barrier in the kidney and are crucial for glomerular permselectivity. These highly differentiated cells are vulnerable to an array of noxious stimuli that prevail in several ...
Rajkishor Nishad +6 more
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Acta Pharmacologica Sinica, 2021 Diabetic kidney disease (DKD) is one of the microvascular complications of diabetes mellitus and a major cause of end-stage renal disease with limited treatment options.
Xue-Qi Liu, Wei Zhu, Yonggui Wu
exaly +2 more sources
Spironolactone alleviates diabetic nephropathy through promoting autophagy in podocytes [PDF]
International Urology and Nephrology, 2019 PurposePodocytes are terminally differentiated cells lining the Bowman’s capsule. Podocytes are critical for the proper glomerular filtration barrier function.
Dan Dong +5 more
openalex +2 more sources
Nature Biomedical Engineering, 2017 An in vitro model of the human kidney glomerulus—the major site of blood filtration—could facilitate drug discovery and illuminate kidney-disease mechanisms.
Samira Musah +2 more
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Epigenetic Alterations in Podocytes in Diabetic Nephropathy [PDF]
Frontiers in Pharmacology, 2021 Recently, epigenetic alterations have been shown to be involved in the pathogenesis of diabetes and its complications. Kidney podocytes, which are glomerular epithelial cells, are important cells that form a slit membrane—a barrier for proteinuria ...
Erina Sugita +3 more
doaj +2 more sources
Scientific Reports, 2017 New data indicate that abnormal glomerular endothelial cell (GEC)-podocyte crosstalk plays a critical role in diabetic nephropathy (DN). The aim of our study is to investigate the role of exosomes from high glucose (HG)-treated GECs in the epithelial ...
Yanbin Gao, Liping Xu, Wanyu Dang
exaly +2 more sources
Activation of Rac-1 and RhoA contributes to podocyte injury in chronic kidney disease [PDF]
, 2013 Rho-family GTPases like RhoA and Rac-1 are potent regulators of cellular signaling that control gene expression, migration and inflammation. Activation of Rho-GTPases has been linked to podocyte dysfunction, a feature of chronic kidney diseases (CKD). We
Amann, Kerstin +13 more
core +16 more sources
Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice
Nature Medicine, 2017 Chengxiang Qiu +2 more
exaly +2 more sources
MCC Regulator of WNT Signaling Pathway (MCC) Is a Podocyte Essential Gene
Frontiers in Medicine, 2021 Podocytes are an integral part of the glomerular filtration barrier. Many genes are already known to be essential for podocyte survival, structure and function, but there are more podocyte essential genes to be identified. By single-cell RNA-seq of mouse
Hui Song +6 more
doaj +1 more source
Mfn2 Regulates High Glucose-Induced MAMs Dysfunction and Apoptosis in Podocytes via PERK Pathway
Frontiers in Cell and Developmental Biology, 2021 The endoplasmic reticulum (ER) stress and mitochondrial dysfunction in high glucose (HG)-induced podocyte injury have been demonstrated to the progression of diabetic kidney disease (DKD). However, the pathological mechanisms remain equivocal. Mitofusin2
Yun Cao +7 more
semanticscholar +1 more source