Results 1 to 10 of about 50,846 (317)

Efficient delivery of small RNAs to podocytes in vitro by direct exosome transfection [PDF]

Journal of Nanobiotechnology
Background Podocytes are a crucial component of the glomerular filtration barrier, and changes in their 3D structure contribute to over 80% of chronic kidney disease (CKD) cases.
Tim Lange, Luzia Maron, Claudia Weber, Doreen Biedenweg, Rabea Schlüter, Nicole Endlich   +5 more
doaj   +2 more sources

Isolation of Podocyte Cell Fractions From Mouse Kidney Using Magnetic Activated Cell Sorting (MACS) [PDF]

Bio-Protocol
Glomerular diseases characterized by injury to post-mitotic epithelial cells called podocytes are a leading cause of chronic kidney disease. Yet, isolating podocytes from the kidney for transcriptomic, proteomic, and metabolomic studies has been a major ...
Jeffrey Pippin, Carol Loretz, Diana Eng, Oliver Wessely, Stuart Shankland   +4 more
doaj   +2 more sources

MCC Regulator of WNT Signaling Pathway (MCC) Is a Podocyte Essential Gene

Frontiers in Medicine, 2021
Podocytes are an integral part of the glomerular filtration barrier. Many genes are already known to be essential for podocyte survival, structure and function, but there are more podocyte essential genes to be identified. By single-cell RNA-seq of mouse
Hui Song, Lulu Zhuang, Xiaodong Xu, Jingsong Shi, Weixin Hu, Zhihong Liu, Shaolin Shi   +6 more
doaj   +1 more source

The directed differentiation of human iPS cells into kidney podocytes. [PDF]

PLoS ONE, 2012
The loss of glomerular podocytes is a key event in the progression of chronic kidney disease resulting in proteinuria and declining function. Podocytes are slow cycling cells that are considered terminally differentiated. Here we provide the first report
Bi Song, Alexandra M Smink, Christina V Jones, Judy M Callaghan, Stephen D Firth, Claude A Bernard, Andrew L Laslett, Peter G Kerr, Sharon D Ricardo   +8 more
doaj   +1 more source

Regulation of TRPML1 channel activity and inflammatory exosome release by endogenously produced reactive oxygen species in mouse podocytes

Redox Biology, 2021
The nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome in podocytes has been implicated in the initiation of glomerular inflammation during hyperhomocysteinemia (hHcy).
Guangbi Li, Dandan Huang, Ningjun Li, Joseph K. Ritter, Pin-Lan Li   +4 more
doaj   +1 more source

C-type lectin-like receptor (CLEC)-2, the ligand of podoplanin, induces morphological changes in podocytes

Scientific Reports, 2022
Podoplanin (PDPN) is intensely expressed on the podocyte membrane in an evolutionally conserved manner. CLEC-2, the endogenous ligand of PDPN, is highly expressed in platelets and also exists in a soluble form in plasma.
Keiko Tanaka, Masafumi Tanaka, Nobuo Watanabe, Masatoshi Ito, Ira Pastan, Masahiro Koizumi, Taiji Matsusaka   +6 more
doaj   +1 more source

Knockout of the neonatal Fc receptor alters immune complex trafficking and lysosomal function in cultured podocytes.

PLoS ONE, 2023
Podocytes are key to preventing the filtration of serum proteins into the urine. Recent evidence also suggests that in immune mediated kidney diseases, podocytes are the targets of immune complexes (ICs).
George Haddad, James Dylewski, River Evans, Linda Lewis, Judith Blaine   +4 more
doaj   +1 more source

Podocytes derived from human induced pluripotent stem cells: characterization, comparison, and modeling of diabetic kidney disease

Stem Cell Research & Therapy, 2022
Background In diabetic kidney disease, high glucose damages specialized cells called podocytes that filter blood in the glomerulus. In vitro culture of podocytes is crucial for modeling of diabetic nephropathy and genetic podocytopathies and to ...
Julie Bejoy, Justin M. Farry, Jennifer L. Peek, Mariana C. Cabatu, Felisha M. Williams, Richard C. Welch, Eddie S. Qian, Lauren E. Woodard   +7 more
doaj   +1 more source

Hsa_circ_0037128 aggravates high glucose-induced podocytes injury in diabetic nephropathy through mediating miR-31-5p/KLF9

Autoimmunity, 2022
Background Circular RNA is a key regulator involved in the progression of many human diseases including diabetic nephropathy (DN). However, the role and mechanism of hsa_circ_0037128 in the occurrence and development of DN remains to be explored. Methods
Rong Fang, Xiangchang Cao, Yaping Zhu, Qiming Chen   +3 more
doaj   +1 more source

Triptolide ameliorates fine particulate matter-induced podocytes injury via regulating NF-κB signaling pathway

BMC Molecular and Cell Biology, 2020
Background PM2.5 is associated closely with an increased risk of membranous nephropathy (MN), however, whether PM2.5 could induce podocytes injury, the underlying pathology for MN, has not be thoroughly studied.
Qiang Wan, Zhongyong Liu, Ming Yang, Peng Deng, Nana Tang, Yanwei Liu   +5 more
doaj   +1 more source