Results 11 to 20 of about 34,405 (271)
Podocytes [version 1; referees: 2 approved] [PDF]
F1000Research, 2016 Podocytes are highly specialized cells of the kidney glomerulus that wrap around capillaries and that neighbor cells of the Bowman’s capsule. When it comes to glomerular filtration, podocytes play an active role in preventing plasma proteins from ...
Jochen Reiser, Mehmet M. Altintas
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Podocyte Injury Damages Other Podocytes [PDF]
Journal of the American Society of Nephrology, 2011 Loss of podocytes promotes glomerulosclerosis, but whether this results from a continued primary insult or a secondary mechanism triggered by the initial loss of podocytes is unknown. We generated chimeric mice in which only a subpopulation of podocytes expressed hCD25, which is the receptor for the immunotoxin LMB2.
Taiji, Matsusaka +6 more
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Kidney International, 2009 Recent insights have defined the central role of podocytes both in rare genetic diseases and as a general determinant of the progression of human glomerular diseases. In a recent issue of Nature, Weavers et al. described a podocyte-like cell type in Drosophila, the nephrocyte, that closely resembles mammalian podocytes, including the nephrin-based slit
Simons, Matias, Huber, Tobias B.
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Targeting Rapamycin to Podocytes Using a Vascular Cell Adhesion Molecule-1 (VCAM-1)-Harnessed SAINT-Based Lipid Carrier System. [PDF]
PLoS ONE, 2015 Together with mesangial cells, glomerular endothelial cells and the basement membrane, podocytes constitute the glomerular filtration barrier (GFB) of the kidney. Podocytes play a pivotal role in the progression of various kidney-related diseases such as
Ganesh Ram R Visweswaran +5 more
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CdGAP maintains podocyte function and modulates focal adhesions in a Src kinase-dependent manner
Scientific Reports, 2022 Rho GTPases are regulators of the actin cytoskeleton and their activity is modulated by GTPase-activating proteins (GAPs) and guanine nucleotide exchanging factors (GEFs).
Jun Matsuda +9 more
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Podocytes Produce and Secrete Functional Complement C3 and Complement Factor H
Frontiers in Immunology, 2020 Podocytes are an important part of the glomerular filtration barrier and the key player in the development of proteinuria, which is an early feature of complement mediated renal diseases.
Anne K. Mühlig +14 more
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cAMP signaling prevents podocyte apoptosis via activation of protein kinase A and mitochondrial fusion. [PDF]
PLoS ONE, 2014 Our previous in vitro studies suggested that cyclic AMP (cAMP) signaling prevents adriamycin (ADR) and puromycin aminonucleoside (PAN)-induced apoptosis in podocytes.
Xiaoying Li +8 more
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Podocyte Mitosis - A Catastrophe [PDF]
Current Molecular Medicine, 2012 Podocyte loss plays a key role in the progression of glomerular disorders towards glomerulosclerosis and chronic kidney disease. Podocytes form unique cytoplasmic extensions, foot processes, which attach to the outer surface of the glomerular basement membrane and interdigitate with neighboring podocytes to form the slit diaphragm.
LASAGNI, LAURA +4 more
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Establishment of protein delivery systems targeting podocytes. [PDF]
PLoS ONE, 2010 Podocytes are uniquely structured cells that are critical to the kidney filtration barrier. Their anatomic location on the outer side of the glomerular capillaries expose podocytes to large quantities of both plasma and urinary components and thus are ...
Wen Chih Chiang +5 more
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JCI Insight, 2021 The transcription factor Twist1 regulates several processes that could impact kidney disease progression, including epithelial cell differentiation and inflammatory cytokine induction.
Jiafa Ren +9 more
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