Results 11 to 20 of about 68,048 (352)
Podocytes [version 1; referees: 2 approved] [PDF]
F1000Research, 2016 Podocytes are highly specialized cells of the kidney glomerulus that wrap around capillaries and that neighbor cells of the Bowman’s capsule. When it comes to glomerular filtration, podocytes play an active role in preventing plasma proteins from ...
Jochen Reiser, Mehmet M. Altintas
doaj +4 more sources
Aberrantly glycosylated IgG elicits pathogenic signaling in podocytes and signifies lupus nephritis
JCI Insight, 2021 Lupus nephritis (LN) is a serious complication occurring in 50% of patients with systemic lupus erythematosus (SLE) for which there is a lack of biomarkers, a lack of specific medications, and a lack of a clear understanding of its pathogenesis.
Rhea Bhargava +9 more
semanticscholar +1 more source
The directed differentiation of human iPS cells into kidney podocytes. [PDF]
PLoS ONE, 2012 The loss of glomerular podocytes is a key event in the progression of chronic kidney disease resulting in proteinuria and declining function. Podocytes are slow cycling cells that are considered terminally differentiated. Here we provide the first report
Bi Song +8 more
doaj +1 more source
Podocyte Injury Damages Other Podocytes [PDF]
Journal of the American Society of Nephrology, 2011 Loss of podocytes promotes glomerulosclerosis, but whether this results from a continued primary insult or a secondary mechanism triggered by the initial loss of podocytes is unknown. We generated chimeric mice in which only a subpopulation of podocytes expressed hCD25, which is the receptor for the immunotoxin LMB2.
Taiji, Matsusaka +6 more
openaire +2 more sources
Redox Biology, 2021 The nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome in podocytes has been implicated in the initiation of glomerular inflammation during hyperhomocysteinemia (hHcy).
Guangbi Li +4 more
doaj +1 more source
PLoS ONE, 2023 Podocytes are key to preventing the filtration of serum proteins into the urine. Recent evidence also suggests that in immune mediated kidney diseases, podocytes are the targets of immune complexes (ICs).
George Haddad +4 more
doaj +1 more source
Scientific Reports, 2022 Podoplanin (PDPN) is intensely expressed on the podocyte membrane in an evolutionally conserved manner. CLEC-2, the endogenous ligand of PDPN, is highly expressed in platelets and also exists in a soluble form in plasma.
Keiko Tanaka +6 more
doaj +1 more source
Stem Cell Research & Therapy, 2022 Background In diabetic kidney disease, high glucose damages specialized cells called podocytes that filter blood in the glomerulus. In vitro culture of podocytes is crucial for modeling of diabetic nephropathy and genetic podocytopathies and to ...
Julie Bejoy +7 more
doaj +1 more source
Podocytes: the Weakest Link in Diabetic Kidney Disease?
Current Diabetes Reports, 2016 Jamie S Lin, Katalin Susztak
exaly +2 more sources
Autoimmunity, 2022 Background Circular RNA is a key regulator involved in the progression of many human diseases including diabetic nephropathy (DN). However, the role and mechanism of hsa_circ_0037128 in the occurrence and development of DN remains to be explored. Methods
Rong Fang +3 more
doaj +1 more source