Results 11 to 20 of about 27,144 (229)
BMC Molecular and Cell Biology, 2020 Background PM2.5 is associated closely with an increased risk of membranous nephropathy (MN), however, whether PM2.5 could induce podocytes injury, the underlying pathology for MN, has not be thoroughly studied.
Qiang Wan +5 more
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Scientific Reports, 2023 Decreased ATP Binding Cassette Transporter A1 (ABCA1) expression and caspase-4-mediated noncanonical inflammasome contribution have been described in podocytes in diabetic kidney disease (DKD).
Marie Ito +11 more
doaj +1 more source
Targeting Rapamycin to Podocytes Using a Vascular Cell Adhesion Molecule-1 (VCAM-1)-Harnessed SAINT-Based Lipid Carrier System. [PDF]
PLoS ONE, 2015 Together with mesangial cells, glomerular endothelial cells and the basement membrane, podocytes constitute the glomerular filtration barrier (GFB) of the kidney. Podocytes play a pivotal role in the progression of various kidney-related diseases such as
Ganesh Ram R Visweswaran +5 more
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CdGAP maintains podocyte function and modulates focal adhesions in a Src kinase-dependent manner
Scientific Reports, 2022 Rho GTPases are regulators of the actin cytoskeleton and their activity is modulated by GTPase-activating proteins (GAPs) and guanine nucleotide exchanging factors (GEFs).
Jun Matsuda +9 more
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Podocytes Produce and Secrete Functional Complement C3 and Complement Factor H
Frontiers in Immunology, 2020 Podocytes are an important part of the glomerular filtration barrier and the key player in the development of proteinuria, which is an early feature of complement mediated renal diseases.
Anne K. Mühlig +14 more
doaj +1 more source
Establishment of protein delivery systems targeting podocytes. [PDF]
PLoS ONE, 2010 Podocytes are uniquely structured cells that are critical to the kidney filtration barrier. Their anatomic location on the outer side of the glomerular capillaries expose podocytes to large quantities of both plasma and urinary components and thus are ...
Wen Chih Chiang +5 more
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Podocyte Mitosis - A Catastrophe [PDF]
Current Molecular Medicine, 2012 Podocyte loss plays a key role in the progression of glomerular disorders towards glomerulosclerosis and chronic kidney disease. Podocytes form unique cytoplasmic extensions, foot processes, which attach to the outer surface of the glomerular basement membrane and interdigitate with neighboring podocytes to form the slit diaphragm.
LASAGNI, LAURA +4 more
openaire +3 more sources
cAMP signaling prevents podocyte apoptosis via activation of protein kinase A and mitochondrial fusion. [PDF]
PLoS ONE, 2014 Our previous in vitro studies suggested that cyclic AMP (cAMP) signaling prevents adriamycin (ADR) and puromycin aminonucleoside (PAN)-induced apoptosis in podocytes.
Xiaoying Li +8 more
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JCI Insight, 2021 The transcription factor Twist1 regulates several processes that could impact kidney disease progression, including epithelial cell differentiation and inflammatory cytokine induction.
Jiafa Ren +9 more
doaj +1 more source
Scientific Reports, 2023 Mycophenolate Mofetil (MMF) has an established role as a therapeutic agent in childhood nephrotic syndrome. While other immunosuppressants have been shown to positively affect podocytes, direct effects of MMF on podocytes remain largely unknown.
Seif El Din Abo Zed +12 more
doaj +1 more source