Results 21 to 30 of about 68,048 (352)
A Novel Role of Neutrophil Elastase in Podocyte Dysfunction Induced by High Glucose, PMA, and MDP. [PDF]
J Cell PhysiolPodocyte injury occurs as a result of neutrophil elastase activity, a process in which NOD2 plays a contributing role. ABSTRACT Podocytes are not only the key regulators of glomerular filtration barrier dynamics but also exhibit immunological properties.
Kulesza T +9 more
europepmc +2 more sources
Regulation of the Actin Cytoskeleton in Podocytes
Cells, 2020 Podocytes are an integral part of the glomerular filtration barrier, a structure that prevents filtration of large proteins and macromolecules into the urine.
J. Blaine, James F Dylewski
semanticscholar +1 more source
Endothelin and the podocyte [PDF]
Clinical Kidney Journal, 2012 In the past decade, research has advanced our understanding how endothelin contributes to proteinuria and glomerulosclerosis. Data from pre-clinical and clinical studies now provide evidence that proteinuric diseases such as focal segmental glomerulosclerosis and diabetic nephropathy as well as hypertension nephropathy are sensitive to treatment with ...
Barton, Matthias, Tharaux, Pierre-Louis
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Kidney International, 2009 Recent insights have defined the central role of podocytes both in rare genetic diseases and as a general determinant of the progression of human glomerular diseases. In a recent issue of Nature, Weavers et al. described a podocyte-like cell type in Drosophila, the nephrocyte, that closely resembles mammalian podocytes, including the nephrin-based slit
Simons, Matias, Huber, Tobias B.
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BMC Molecular and Cell Biology, 2020 Background PM2.5 is associated closely with an increased risk of membranous nephropathy (MN), however, whether PM2.5 could induce podocytes injury, the underlying pathology for MN, has not be thoroughly studied.
Qiang Wan +5 more
doaj +1 more source
BioMed Research International, 2020 Background Podocyte migration is actively involved in the process of podocyte loss and proteinuria production, which is closely associated with the development of diabetic nephropathy (DN).
Juan Jin +5 more
semanticscholar +1 more source
Scientific Reports, 2023 Decreased ATP Binding Cassette Transporter A1 (ABCA1) expression and caspase-4-mediated noncanonical inflammasome contribution have been described in podocytes in diabetic kidney disease (DKD).
Marie Ito +11 more
doaj +1 more source
Podocyte Biology and the Emerging Understanding of Podocyte Diseases [PDF]
American Journal of Nephrology, 2003 The understanding of the unique molecular apparatus of the podocyte has increased dramatically in recent years. This new knowledge has improved the diagnosis and classification of the diseases that have been termed podocytopathies. Podocyte injury frequently leads to reorganization of the slit diaphragm and reorganization of the foot process structure.
Laura, Barisoni, Peter, Mundel
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Targeting Rapamycin to Podocytes Using a Vascular Cell Adhesion Molecule-1 (VCAM-1)-Harnessed SAINT-Based Lipid Carrier System. [PDF]
PLoS ONE, 2015 Together with mesangial cells, glomerular endothelial cells and the basement membrane, podocytes constitute the glomerular filtration barrier (GFB) of the kidney. Podocytes play a pivotal role in the progression of various kidney-related diseases such as
Ganesh Ram R Visweswaran +5 more
doaj +1 more source
A Potential Role for Mechanical Forces in the Detachment of Podocytes and the Progression of CKD
Journal of the American Society of Nephrology: JASN, 2015 Wilhelm Kriz, Kevin V Lemley
exaly +2 more sources