Results 31 to 40 of about 68,048 (352)
Establishment of protein delivery systems targeting podocytes. [PDF]
PLoS ONE, 2010 Podocytes are uniquely structured cells that are critical to the kidney filtration barrier. Their anatomic location on the outer side of the glomerular capillaries expose podocytes to large quantities of both plasma and urinary components and thus are ...
Wen Chih Chiang +5 more
doaj +1 more source
Regulation of podocyte survival and endoplasmic reticulum stress by fatty acids and its modification by Stearoyl-CoA desaturases and cyclic AMP [PDF]
, 2011 Podocyte apoptosis is a hallmark in the development and progression of diabetic nephropathy (DN). Several factors of the diabetic milieu are known to induce podocyte apoptosis. Currently, the role of free fatty acids (FFAs) for podocytopathy and podocyte
Sieber, Jonas
core +1 more source
CXCL16 and oxLDL are induced in the onset of diabetic nephropathy [PDF]
, 2009 Diabetic nephropathy (DN) is a major cause of end-stage renal failure worldwide. Oxidative stress has been reported to be a major culprit of the disease and increased oxidized low density lipoprotein (oxLDL) immune complexes were found in patients with ...
Abdel-Aziz, Abdel-Aziz H. +11 more
core +1 more source
Journal of the Endocrine Society, 2020 Diabetic kidney disease (DKD) is an important public health problem. Podocyte injury is a central event in the mechanism of DKD development. Podocytes are terminally differentiated, highly specialized glomerular visceral epithelial cells critical for the
Igor Kravets, S. Mallipattu
semanticscholar +1 more source
Podocytes Produce and Secrete Functional Complement C3 and Complement Factor H
Frontiers in Immunology, 2020 Podocytes are an important part of the glomerular filtration barrier and the key player in the development of proteinuria, which is an early feature of complement mediated renal diseases.
Anne K. Mühlig +14 more
doaj +1 more source
cAMP signaling prevents podocyte apoptosis via activation of protein kinase A and mitochondrial fusion. [PDF]
PLoS ONE, 2014 Our previous in vitro studies suggested that cyclic AMP (cAMP) signaling prevents adriamycin (ADR) and puromycin aminonucleoside (PAN)-induced apoptosis in podocytes.
Xiaoying Li +8 more
doaj +1 more source
Theranostics, 2019 Elevated levels of plasma free fatty acid (FFA) and disturbed mitochondrial dynamics play crucial roles in the pathogenesis of diabetic kidney disease (DKD).
Xin Qin +12 more
semanticscholar +1 more source
C3a receptor blockade protects podocytes from injury in diabetic nephropathy.
JCI Insight, 2020 Renal activation of the complement system has been described in patients with diabetic nephropathy (DN), although its pathological relevance is still ill-defined.
M. Morigi +10 more
semanticscholar +1 more source
CdGAP maintains podocyte function and modulates focal adhesions in a Src kinase-dependent manner
Scientific Reports, 2022 Rho GTPases are regulators of the actin cytoskeleton and their activity is modulated by GTPase-activating proteins (GAPs) and guanine nucleotide exchanging factors (GEFs).
Jun Matsuda +9 more
doaj +1 more source
Journal of the American Society of Nephrology, 2020 BACKGROUND In males with classic Fabry disease, the processes leading to the frequent outcome of ESKD are poorly understood. Defects in the gene encoding α-galactosidase A lead to accumulation of globotriaosylceramide (GL3) in various cell types.
Behzad Najafian +5 more
semanticscholar +1 more source