Results 31 to 40 of about 27,144 (229)

Growth hormone induces mitotic catastrophe of glomerular podocytes and contributes to proteinuria

Cell Death and Disease, 2021
Glomerular podocytes are integral members of the glomerular filtration barrier in the kidney and are crucial for glomerular permselectivity. These highly differentiated cells are vulnerable to an array of noxious stimuli that prevail in several ...
Rajkishor Nishad, Dhanunjay Mukhi, Ashish Kumar Singh, Manga Motrapu, Kumaraswami Chintala, Prasad Tammineni, Anil K. Pasupulati   +6 more
doaj   +1 more source

Preparation of Human Kidney Progenitor Cultures and Their Differentiation into Podocytes

Bio-Protocol, 2023
Kidney diseases are a global health concern. Modeling of kidney disease for translational research is often challenging because of species specificities or the postmitotic status of kidney epithelial cells that make primary cultures, for example ...
Maria Elena Melica, Maria Lucia Angelotti, Giulia Antonelli, Anna Peired, Carolina Conte, Letizia De Chiara, Benedetta Mazzinghi, Elena Lazzeri, Laura Lasagni, Paola Romagnani   +9 more
doaj   +1 more source

The expression and significance of neuronal iconic proteins in podocytes.

PLoS ONE, 2014
Growing evidence suggests that there are many common cell biological features shared by neurons and podocytes; however, the mechanism of podocyte foot process formation remains unclear. Comparing the mechanisms of process formation between two cell types
Yu Sun, Hongxia Zhang, Ruimin Hu, Jianyong Sun, Xing Mao, Zhonghua Zhao, Qi Chen, Zhigang Zhang   +7 more
doaj   +1 more source

WNK1 Kinase Activity Is Required for the Functional Maintenance of Podocyte Structure. [PDF]

FASEB J
The acute effects of WNK1 kinase inhibition on podocyte structure and function were determined at the level of: 1) renal function, by measurements of urinary protein and imaging of glomerular synaptopodin, 2) podocyte cell, by measurements and localization of actomyosin proteins and their regulators, and 3) focal adhesions at cell membrane extensions ...
Liu Z, Lee E, Jiang S, Yoon J, Ahmed F, Rahman MA, Bleicher P, Suleiman HY, Bruggeman LA, Miller RT, Chang AN.   +10 more
europepmc   +2 more sources

Bioprinting Organs—Science or Fiction?—A Review From Students to Students

Advanced Healthcare Materials, EarlyView.
Bioprinting artificial organs has the potential to revolutionize the medical field. This is a comprehensive review of the bioprinting workflow delving into the latest advancements in bioinks, materials and bioprinting techniques, exploring the critical stages of tissue maturation and functionality.
Nicoletta Murenu, Camilla Mussoni, Mateo S. Andrade Mier, Paula Buettner, Nathaly Chicaiza‐Cabezas, Yi‐Yu Robin Dai, Jessica Faber, Maren Fiedler, Zan Lamberger, Xuen Jen Ng, Vanessa Moessler, Anna Rederer, Jonas Roeder, Sabrina Stecher, Katinka Theis, Jeanette Weigelt, Silvia Budday, Gregor Lang, Natascha Schaefer   +18 more
wiley   +1 more source

Computational Modeling Meets 3D Bioprinting: Emerging Synergies in Cardiovascular Disease Modeling

Advanced Healthcare Materials, EarlyView.
Emerging advances in three‐dimensional bioprinting and computational modeling are reshaping cardiovascular (CV) research by enabling more realistic, patient‐specific tissue platforms. This review surveys cutting‐edge approaches that merge biomimetic CV constructs with computational simulations to overcome the limitations of traditional models, improve ...
Tanmay Mukherjee, Mehdi Salar Amoli, Sarah Rezapourdamanab, Lama Rita El Shammas, Martin L. Tomov, Emilio A. Mendiola, Vahid Serpooshan, Reza Avazmohammadi   +7 more
wiley   +1 more source

A Liquid-Based Cytology System, without the Use of Cytocentrifugation, for Detection of Podocytes in Urine Samples of Patients with Diabetic Nephropathy

Journal of Diabetes Research, 2019
Objective. Podocytes have highly differentiated functions and are extremely difficult to grow; thus, damage of podocytes is associated with glomerular dysfunction.
Moritsugu Kimura, Masao Toyoda, Nobumichi Saito, Noriko Kaneyama, Han Miyatake, Eitaro Tanaka, Hirotaka Komaba, Masanori Hara, Masafumi Fukagawa   +8 more
doaj   +1 more source

ADAM10 is expressed in human podocytes and found in urinary vesicles of patients with glomerular kidney diseases

Journal of Biomedical Science, 2010
Background The importance of the Notch signaling in the development of glomerular diseases has been recently described. Therefore we analyzed in podocytes the expression and activity of ADAM10, one important component of the Notch signaling complex ...
Weide Thomas, Hillmann Anja, Gauer Stefan, Altevogt Peter, Ludwig Andreas, Hauser Ingeborg A, Doberstein Kai, Abdel-Bakky Mohamed, Schramme Anja, Gutwein Paul, Jespersen Christine, Eberhardt Wolfgang, Pfeilschifter Josef   +12 more
doaj   +1 more source

Unravelling the Role of PAX2 Mutation in Human Focal Segmental Glomerulosclerosis

Biomedicines, 2021
No effective treatments are available for familial steroid-resistant Focal Segmental Glomerulosclerosis (FSGS), characterized by proteinuria due to ultrastructural abnormalities in glomerular podocytes. Here, we studied a private PAX2 mutation identified
Lorena Longaretti, Piera Trionfini, Valerio Brizi, Christodoulos Xinaris, Caterina Mele, Matteo Breno, Elena Romano, Roberta Giampietro, Giuseppe Remuzzi, Ariela Benigni, Susanna Tomasoni   +10 more
doaj   +1 more source

Endothelin and the podocyte [PDF]

Clinical Kidney Journal, 2012
In the past decade, research has advanced our understanding how endothelin contributes to proteinuria and glomerulosclerosis. Data from pre-clinical and clinical studies now provide evidence that proteinuric diseases such as focal segmental glomerulosclerosis and diabetic nephropathy as well as hypertension nephropathy are sensitive to treatment with ...
Barton, Matthias, Tharaux, Pierre-Louis
openaire   +2 more sources