Results 41 to 50 of about 50,846 (317)
Insulin in podocyte podiatry [PDF]
Journal of Diabetes Investigation, 2011 Diabetic nephropathy, a major complication of diabetes mellitus, is the leading cause of end‐stage renal disease worldwide and recently it has been recognized as a high risk for the development of cardiovascular disease. Clinical features of diabetic nephropathy are development of albuminuria followed by persistent proteinuria and, later, reduction of ...
Yuichi Makino, Masakazu Haneda
openaire +3 more sources
Epigenetic Alterations in Podocytes in Diabetic Nephropathy
Frontiers in Pharmacology, 2021 Recently, epigenetic alterations have been shown to be involved in the pathogenesis of diabetes and its complications. Kidney podocytes, which are glomerular epithelial cells, are important cells that form a slit membrane—a barrier for proteinuria ...
Erina Sugita +3 more
doaj +1 more source
Permselectivity of the glomerular wall examined with iron compound tracer [PDF]
, 1977 Rat kidney endothelial cell morphology was examined after introducing iron colloid particles of positive or negative charge to investigate the relationship between the electric charge and permeation through the glomerular capillary.
Hirata, Kooiti
core +1 more source
Engineered RGD-Treg-Exos Targeted Delivery of miR-218-5p to Activate Mitophagy and Attenuate Podocyte Injury in Diabetic Kidney Disease. [PDF]
Adv Sci (Weinh)Tregs‐Exos deliver miR‐218‐5p to increase mitophagy in podocytes by inhibiting the TNC/TLR4/SRC/FUNDC1 pathway. RGD‐Treg‐Exos, engineered to express RGD peptides on the membrane surface, bind to integrins on the surface of podocytes and effectively target podocytes for the delivery of miR‐218‐5p, which increases mitophagy and reduces apoptosis in ...
Guo Z +11 more
europepmc +2 more sources
Sphingosine 1-phosphate in renal diseases [PDF]
, 2013 Because of its highly bioactive properties sphingosine 1-phosphate (S1P) is an attractive target for the treatment of several diseases. Since the expression of sphingosine kinases as well as S1P receptors was demonstrated in the kidney, questions about ...
Huwiler, Andrea +2 more
core +2 more sources
Preparation of Human Kidney Progenitor Cultures and Their Differentiation into Podocytes
Bio-Protocol, 2023 Kidney diseases are a global health concern. Modeling of kidney disease for translational research is often challenging because of species specificities or the postmitotic status of kidney epithelial cells that make primary cultures, for example ...
Maria Elena Melica +9 more
doaj +1 more source
Kidney360, 2023 As the population in many industrial countries is aging, the risk, incidence, and prevalence of CKD increases. In the kidney, advancing age results in a progressive decrease in nephron number and an increase in glomerulosclerosis. In this review, we focus on the effect of aging on glomerular podocytes, the post-mitotic epithelial cells critical for the
Stuart J. Shankland +4 more
openaire +2 more sources
Genetically Encoded Calcium Indicators: A New Tool in Renal Hypertension Research [PDF]
, 2019 Hypertension is ranked as the third cause of disability-adjusted life-years. The percentage of the population suffering from hypertension will continue to increase over the next years.
Schleifenbaum, Johanna, Zhong, Cheng
core +1 more source
Enzymatic disease of the podocyte [PDF]
Pediatric Nephrology, 2010 Proteinuria is an early sign of kidney disease and has gained increasing attention over the past decade because of its close association with cardio-vascular and renal morbidity and mortality. Podocytes have emerged as the cell type that is critical in maintaining proper functioning of the kidney filter.
Andreas D. Kistler +5 more
openaire +3 more sources
Whole carcass diets: a role for fibre in gastrointestinal health of cheetahs? [PDF]
, 2011 This study was undertaken to test the hypothesis that altered podocyte slit protein nephrin distribution is associated with disturbed polarity protein expressions in podocytes from preeclampsia (PE).
Depauw, Sarah +6 more
core +2 more sources