Results 41 to 50 of about 68,048 (352)

Podocyte Mitosis - A Catastrophe [PDF]

Current Molecular Medicine, 2012
Podocyte loss plays a key role in the progression of glomerular disorders towards glomerulosclerosis and chronic kidney disease. Podocytes form unique cytoplasmic extensions, foot processes, which attach to the outer surface of the glomerular basement membrane and interdigitate with neighboring podocytes to form the slit diaphragm.
LASAGNI, LAURA, LAZZERI, ELENA, Shankland SJ, Anders HJ, ROMAGNANI, PAOLA   +4 more
openaire   +3 more sources

Twist1 in podocytes ameliorates podocyte injury and proteinuria by limiting CCL2-dependent macrophage infiltration

JCI Insight, 2021
The transcription factor Twist1 regulates several processes that could impact kidney disease progression, including epithelial cell differentiation and inflammatory cytokine induction.
Jiafa Ren, Yuemei Xu, Xiaohan Lu, Liming Wang, Shintaro Ide, Gentzon Hall, Tomokazu Souma, Jamie R. Privratsky, Robert F. Spurney, Steven D. Crowley   +9 more
doaj   +1 more source

Mycophenolic acid directly protects podocytes by preserving the actin cytoskeleton and increasing cell survival

Scientific Reports, 2023
Mycophenolate Mofetil (MMF) has an established role as a therapeutic agent in childhood nephrotic syndrome. While other immunosuppressants have been shown to positively affect podocytes, direct effects of MMF on podocytes remain largely unknown.
Seif El Din Abo Zed, Agnes Hackl, Katrin Bohl, Lena Ebert, Emilia Kieckhöfer, Carsten Müller, Kerstin Becker, Gregor Fink, Kai-Dietrich Nüsken, Eva Nüsken, Roman-Ulrich Müller, Bernhard Schermer, Lutz T. Weber   +12 more
doaj   +1 more source

Crosstalk Between SMPDL3b and NADPH Oxidases Mediates Radiation-Induced Damage of Renal Podocytes

Frontiers in Medicine, 2021
Patients undergoing radiotherapy (RT) for various tumors localized in the abdomen or pelvis often suffer from radiation nephrotoxicity as collateral damage. Renal podocytes are vulnerable targets for ionizing radiation and contribute to radiation-induced
Patrick Azzam, Marina Francis, Tarek Youssef, Manal Mroueh, Alaa Abou Daher, Assaad A. Eid, Alessia Fornoni, Brian Marples, Youssef H. Zeidan, Youssef H. Zeidan   +9 more
doaj   +1 more source

Sirt6 Suppresses High Glucose-Induced Mitochondrial Dysfunction and Apoptosis in Podocytes through AMPK Activation

International Journal on Biological Sciences, 2019
Previous studies have shown that mitochondrial dysfunction plays an important role in high- glucose(HG)-induced podocyte injury and thus contributes to the progression of diabetic nephropathy(DN).
Yanqin Fan, Qian Yang, Yingjie Yang, Zhao Gao, Yiqiong Ma, Lu Zhang, W. Liang, G. Ding   +7 more
semanticscholar   +1 more source

M2 macrophage‐derived exosomal miR‐25‐3p improves high glucose‐induced podocytes injury through activation autophagy via inhibiting DUSP1 expression

IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, 2020
Diabetic nephropathy (DN) is the primary reason of chronic kidney disease. The aim of our study is to explore the role and action mechanism of M2 macrophage‐derived exosomes in high glucose (HG)‐induced podocytes injury. Here, 30 mmol/L of HG was used to
Haihua Huang, Huiyun Liu, Jiazhen Tang, Wenqiong Xu, Hu Gan, Qiwei Fan, Wei Zhang   +6 more
semanticscholar   +1 more source

The targeted podocyte [PDF]

Journal of Clinical Investigation, 2011
The podocyte plays a key role both in maintenance of the glomerular filtration barrier and in glomerular structural integrity. Podocyte injury and loss contribute to proteinuria and progressive sclerosis. Inhibitors of mammalian target of rapamycin (mTOR) have variably decreased or caused proteinuria and sclerosis in human disease and experimental ...
openaire   +2 more sources

ATP-binding cassette A1 deficiency causes cardiolipin-driven mitochondrial dysfunction in podocytes.

Journal of Clinical Investigation, 2019
Fibroblasts from patients with Tangier disease carrying ATP-binding cassette A1 (ABCA1) loss-of-function mutations are characterized by cardiolipin accumulation, a mitochondrial-specific phospholipid.
G. Ducasa, A. Mitrofanova, Shamroop Mallela, Xiaochen Liu, J. Molina, A. Sloan, C. Pedigo, M. Ge, Javier Santos, Yanio Hernandez, Jin-Ju Kim, C. Maugeais, A. Mendez, V. Nair, M. Kretzler, G. Burke, R. Nelson, Y. Ishimoto, R. Inagi, Santanu Banerjee, Shaoyi Liu, H. Szeto, S. Merscher, Flavia Fontanesi, A. Fornoni   +24 more
semanticscholar   +1 more source

Sirt6 deficiency aggravates angiotensin II-induced cholesterol accumulation and injury in podocytes

Theranostics, 2020
Disturbed renal lipid metabolism, especially cholesterol dysregulation plays a crucial role in the pathogenesis of chronic kidney disease (CKD). We recently reported that angiotensin (Ang) II could induce cholesterol accumulation and injury in podocytes.
Qian Yang, Jijia Hu, Yingjie Yang, Zhaowei Chen, Jun Feng, Zijing Zhu, Huiming Wang, Dingping Yang, W. Liang, G. Ding   +9 more
semanticscholar   +1 more source

SMURF1 activates the cGAS/STING/IFN-1 signal axis by mediating YY1 ubiquitination to accelerate the progression of lupus nephritis

Autoimmunity, 2023
Aggravated endoplasmic reticulum stress (ERS) and apoptosis in podocytes play an important role in lupus nephritis (LN) progression, but its mechanism is still unclear.
Xiaoyan Li, Sisi Tao, Zhiquan Xu, Yi Ren, Wei Xiang, Xiaojie He   +5 more
doaj   +1 more source