Results 21 to 30 of about 86,994 (300)

Development of a new oral poliovirus vaccine for the eradication end game using codon deoptimization

npj Vaccines, 2020
Enormous progress has been made in global efforts to eradicate poliovirus, using live-attenuated Sabin oral poliovirus vaccine (OPV). However, as the incidence of disease due to wild poliovirus has declined, vaccine-derived poliovirus (VDPV) has emerged ...
Jennifer L. Konopka-Anstadt, R. Campagnoli, A. Vincent, J. Shaw, Lingxiu Wei, N. Wynn, S. Smithee, E. Bujáki, Ming Te Yeh, M. Laassri, T. Zagorodnyaya, A. Weiner, K. Chumakov, R. Andino, A. Macadam, O. Kew, C. Burns   +16 more
semanticscholar   +1 more source

Update on Vaccine-Derived Poliovirus Outbreaks — Worldwide, July 2019–February 2020

MMWR. Morbidity and mortality weekly report, 2020
Circulating vaccine-derived polioviruses (cVDPVs) can emerge in areas with low poliovirus immunity and cause outbreaks* of paralytic polio (1-5). Among the three types of wild poliovirus, type 2 was declared eradicated in 2015 (1,2). The use of trivalent
M. Alleman, J. Jorba, Sharon A. Greene, O. Diop, Jane Iber, G. Tallis, A. Goel, E. Wiesen, S. Wassilak, C. Burns   +9 more
semanticscholar   +1 more source

Rapid and Sensitive Direct Detection and Identification of Poliovirus from Stool and Environmental Surveillance Samples by Use of Nanopore Sequencing

Journal of Clinical Microbiology, 2020
Global poliovirus surveillance involves virus isolation from stool and environmental samples, intratypic differential (ITD) by PCR, and sequencing of the VP1 region to distinguish vaccine (Sabin), vaccine-derived, and wild-type polioviruses and to ensure
Alexander G. Shaw, M. Majumdar, C. Troman, Á. O'toole, B. Benny, D. Abraham, I. Praharaj, G. Kang, S. Sharif, M. Alam, S. Shaukat, M. Angez, A. Khurshid, Nayab Mahmood, Y. Arshad, L. Rehman, G. Mujtaba, Ribqa Akthar, M. Salman, D. Klapsa, Yara Hajarha, H. Asghar, A. Bandyopadhyay, A. Rambaut, Javier Martin, N. Grassly   +25 more
semanticscholar   +1 more source

The effect of maternal poliovirus antibodies on the immune responses of infants to poliovirus vaccines

BMC Infectious Diseases, 2020
Background Maternal poliovirus antibodies could provide passive immunity to the newborns from poliovirus infection during their first few months of life, but they may impair the immune responses of infants to the poliovirus vaccine as well. In our study,
Siyue Jia, Rong Tang, Guifan Li, Yuemei Hu, Qi Liang   +4 more
doaj   +1 more source

Recurrent Glioblastoma Treated with Recombinant Poliovirus

New England Journal of Medicine, 2018
BACKGROUND The prognosis of patients with recurrent World Health Organization (WHO) grade IV malignant glioma is dismal, and there is currently no effective therapy.
A. Desjardins, M. Gromeier, J. Herndon, N. Beaubier, D. Bolognesi, A. Friedman, H. Friedman, F. McSherry, Andrea M. Muscat, S. Nair, K. Peters, D. Randazzo, J. Sampson, G. Vlahović, William T. Harrison, R. McLendon, D. Ashley, D. Bigner   +17 more
semanticscholar   +1 more source

Poliovirus [PDF]

Pediatrics, 2011
This Policy Statement was retired January 2015. Despite marked progress in global polio eradication, the threat of polio importation into the United States remains; therefore, all children should be protected against the disease. The standard schedule for poliovirus immunization remains 4 doses of inactivated poliovirus vaccine at 2, 4 ...
openaire   +2 more sources

Effects of maternal antibodies in infants on the immunogenicity and safety of inactivated polio vaccine in infants

Human Vaccines & Immunotherapeutics, 2022
The presence of maternal poliovirus antibodies may interfere with the immune response to inactivated polio vaccine (IPV), and its influence on the safety of vaccination is not yet understood.
Shuyu Gao, Mingwei Wei, Kai Chu, Jingxin Li, Fengcai Zhu   +4 more
doaj   +1 more source

Update on Pakistan Polio Eradication Initiative

Journal of Shalamar Medical & Dental College, 2022
The global polio eradication initiative (GPEI) was established in 1988 as a result of the declaration of commitment by the World Health Assembly. In Pakistan, National Emergency Action Plan [NEAP] coined the strategies under government directives to ...
Maryam Riaz Tarar
doaj   +1 more source

Poliovirus biology [PDF]

Structure, 1996
Poliomyelitis has been largely controlled by the use of attenuated live vaccine strains. The molecular basis of attenuation is beginning to be understood, but the interactions between the virus and its human host remain mysterious.
openaire   +2 more sources

Deficiency of immunity to poliovirus type 3: a lurking danger? [PDF]

, 2012
Background: Europe was certified to be polio-free in 2002 by the WHO. However, wild polioviruses remain endemic in India, Pakistan, Afghanistan, and Nigeria, occasionally causing polio outbreaks, as in Tajikistan in 2010.
Doerr, Hans W., Friedrichs, Imke, Rabenau, Holger, Reinheimer, Claudia   +3 more
core   +2 more sources