Results 21 to 30 of about 41,706 (206)

Poliovirus Vaccination Induces a Humoral Immune Response That Cross Reacts With SARS-CoV-2

Frontiers in Medicine, 2021
Background: Millions have been exposed to SARS-CoV-2, but the severity of resultant infections has varied among adults and children, with adults presenting more serious symptomatic cases.
Brittany A. Comunale, Lilly Engineer, Lilly Engineer, Yong Jiang, John C. Andrews, Qianna Liu, Lyuqing Ji, James T. Yurkovich, Roderick A. Comunale, Qiyi Xie   +9 more
doaj   +1 more source

Vaccine-related poliovirus shedding in trivalent polio vaccine and human immunodeficiency virus status: analysis from under five children

BMC Research Notes, 2017
Background Poliomyelitis is an acute viral infection caused by poliovirus and transmitted via the fecal–oral route. The causative agent is one of the three serotypes of poliovirus (serotypes 1, 2, 3) that differ slightly in capsid protein.
Joanne Hassan, Laura Wangai, Peter Borus, Christopher Khayeka–Wandabwa, Lucy Wanja Karani, Mercy Kithinji, Michael Kiptoo   +6 more
doaj   +1 more source

Antiviral Development for the Polio Endgame: Current Progress and Future Directions

Pathogens
As the world is approaching the eradication of wild poliovirus serotype 1, the last of the three wild types, the question of how to maintain a polio-free world becomes imminent.
Hang Xie, Eric E. Rhoden, Hong-Mei Liu, Folake Ogunsemowo, Bernardo A. Mainou, Rachel M. Burke, Cara C. Burns   +6 more
doaj   +1 more source

Establishment of a Poliovirus Containment Program and Containment Certification Process for Poliovirus-Essential Facilities, United States 2017–2022

Pathogens
Upon declaration of poliovirus (PV) type 2 eradication in 2015, the World Health Organization (WHO) published PV containment requirements in the Global Action Plan III (GAPIII) for mitigating the risk of a facility-associated release post eradication. In
Christy Ottendorfer, Bryan Shelby, Cecelia A. Sanders, Anna Llewellyn, Christy Myrick, Christye Brown, Suganthi Suppiah, Kortney Gustin, Lia Haynes Smith   +8 more
doaj   +1 more source

Importation and Circulation of Vaccine-Derived Poliovirus Serotype 2, Senegal, 2020–2021

Emerging Infectious Diseases, 2022
Environmental surveillance for poliovirus is increasingly used in poliovirus eradication efforts as a supplement to acute flaccid paralysis (AFP) surveillance. Environmental surveillance was officially established in 2017 in Senegal, where no poliovirus
Martin Faye, Ousmane Kébé, Boly Diop, NDack Ndiaye, Annick Dosseh, Abdoulaye Sam, Aliou Diallo, Hamet Dia, Jean Pierre Diallo, Ndongo Dia, Davy Evrard Kiori, Ousmane Madiagne Diop, Amadou Alpha Sall, Ousmane Faye   +13 more
doaj   +1 more source

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

Poliomyelitis amidst the COVID-19 pandemic in Africa: Efforts, challenges and recommendations

Clinical Epidemiology and Global Health, 2022
Poliomyelitis is the leading infectious cause of acute flaccid paralysis among children under five years of age, caused by the Wild Poliovirus, with no medical cure other than prevention through vaccination.
Olivier Uwishema, Emmanuel Ebuka Elebesunu, Oumnia Bouaddi, Arushi Kapoor, Samaa Akhtar, Fortune Benjamin Effiong, Adhiraj Chaudhary, Helen Onyeaka   +7 more
doaj   +1 more source

Inactivated Poliovirus Vaccine Protects Transgenic Poliovirus Receptor Mice against Type 3 Poliovirus Challenge [PDF]

Journal of Infectious Diseases, 1997
Transgenic (Tg) mice expressing the human poliovirus receptor (PVR) were vaccinated with inactivated poliovirus vaccine (IPV) and evaluated for induced immunity against type 3 poliomyelitis. One injection of monovalent type 3 IPV elicited protective immunity against wild-type poliovirus.
R E, Taffs, Y V, Chernokhvostova, E M, Dragunsky, T, Nomura, K, Hioki, E C, Beuvery, E A, Fitzgerald, I S, Levenbook, D M, Asher   +8 more
openaire   +2 more sources

TriCON: A Carbon‐Based Triple‐Modal Nanoplatform for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
We developed TriCON, a triple‐modality nanotherapeutic platform, to treat pancreatic ductal adenocarcinoma (PDAC) by synergizing gene editing, chemotherapy, and immunotherapy. TriCON utilizes CRISPR/Cas9 to target the poliovirus receptor (PVR), combined with nano‐encapsulated doxorubicin and checkpoint blockade. This approach achieved significant tumor
Xinyu Peng, Jiaxing Huang, Shengnan Lv, Jian Zhang, Liangliang Zhang, Huan Liu, Yan Liu, Zhen‐An Qiao, Feng Wei, Bao‐Lian Su   +9 more
wiley   +1 more source

Monitoring the VDPV2 outbreak in Egypt during 2020–2021 highlights the crucial role of environmental surveillance and boosting immunization in combating Poliovirus

BMC Infectious Diseases
Background Poliovirus is a highly infectious enterovirus (EV) that primarily affects children and can lead to lifelong paralysis or even death. Vaccine-derived polioviruses (VDPVs) are a great threat since they are derived from the attenuated virus in ...
Menna R. Shabana, Amira Y. Zaghloul, Tamer H. El Shaarawy, Nooran S. Elleboudy, Khaled M. Aboshanab   +4 more
doaj   +1 more source