Results 31 to 40 of about 218,086 (209)

Comparison of Inactivated and Oral Poliovirus Vaccines

, 2013
Introduction: The aim of this study was to compare the rates of systemic and fever reactions of inactivated poliovirus vaccine (IPV) and oral poliovirus vaccine (OPV) at 2, 4, 6 and 18 months of age.
Korkmaz, Huseyin Anil, ÜNAL, BELGİN, AYDIN, ADEM   +2 more
core   +2 more sources

Safety and immunogenicity of inactivated poliovirus vaccine when given with measles–rubella combined vaccine and yellow fever vaccine and when given via different administration routes: a phase 4, randomised, non-inferiority trial in The Gambia

The Lancet Global Health, 2016
Background: The introduction of the inactivated poliovirus vaccine (IPV) represents a crucial step in the polio eradication endgame. This trial examined the safety and immunogenicity of IPV given alongside the measles–rubella and yellow fever vaccines at
Dr. Ed Clarke, MBChB, Yauba Saidu, MD, Jane U Adetifa, MD, Ikechukwu Adigweme, MBBS, Mariama Badjie Hydara, MBBS, Adedapo O Bashorun, MBBS, Ngozi Moneke-Anyanwoke, MBBS, Ama Umesi, MBBS, Elishia Roberts, BSc, Pa Modou Cham, BSc, Michael E Okoye, MBBS, Kevin E Brown, MBBS, Prof. Matthias Niedrig, PhD, Panchali Roy Chowdhury, MSc, Ralf Clemens, MD, Ananda S Bandyopadhyay, MBBS, Jenny Mueller, MD, David J Jeffries, PhD, Prof. Beate Kampmann, MD   +18 more
doaj   +1 more source

Plant-made polio type 3 stabilized VLPs—a candidate synthetic polio vaccine

Nature Communications, 2017
Despite the success of current vaccination against poliomyelitis, safe, cheap and effective vaccines remain sought for continuing eradication effort. Here the authors use plants to express stabilized virus-like particles of type 3 poliovirus that can ...
Johanna Marsian, Helen Fox, Mohammad W. Bahar, Abhay Kotecha, Elizabeth E. Fry, David I. Stuart, Andrew J. Macadam, David J. Rowlands, George P. Lomonossoff   +8 more
doaj   +1 more source

Applying the Concept of Peptide Uniqueness to Anti-Polio Vaccination

Journal of Immunology Research, 2015
Background. Although rare, adverse events may associate with anti-poliovirus vaccination thus possibly hampering global polio eradication worldwide. Objective.
Darja Kanduc, Candida Fasano, Giovanni Capone, Antonella Pesce Delfino, Michele Calabrò, Lorenzo Polimeno   +5 more
doaj   +1 more source

A human monoclonal antibody binds within the poliovirus receptor-binding site to neutralize all three serotypes

Nature Communications, 2023
Global eradication of poliovirus remains elusive, and it is critical to develop next generation vaccines and antivirals. In support of this goal, we map the epitope of human monoclonal antibody 9H2 which is able to neutralize the three serotypes of ...
Andrew J. Charnesky, Julia E. Faust, Hyunwook Lee, Rama Devudu Puligedda, Daniel J. Goetschius, Nadia M. DiNunno, Vaskar Thapa, Carol M. Bator, Sung Hyun (Joseph) Cho, Rahnuma Wahid, Kutub Mahmood, Scott Dessain, Konstantin M. Chumakov, Amy Rosenfeld, Susan L. Hafenstein   +14 more
doaj   +1 more source

Evolution of global polio eradication strategies: targets, vaccines, and supplemental immunization activities (SIAs)

Expert Review of Vaccines
Background Despite multiple revisions of targets and timelines in polio eradication plans since 1988, including changes in supplemental immunization activities (SIAs) that increase immunity above routine immunization (RI) coverage, poliovirus ...
Kimberly M. Thompson, Kamran Badizadegan
doaj   +1 more source

A conserved glutathione binding site in poliovirus is a target for antivirals and vaccine stabilisation

Communications Biology, 2022
Cryo-EM structures reveal the role of glutathione (GSH) in poliovirus (PV) serotype 3 virus-like particle (VLP) stability, suggesting GSH or an analogous tight-binding antiviral offers potential for stabilizing VLP vaccines against PV.
Mohammad W. Bahar, Veronica Nasta, Helen Fox, Lee Sherry, Keith Grehan, Claudine Porta, Andrew J. Macadam, Nicola J. Stonehouse, David J. Rowlands, Elizabeth E. Fry, David I. Stuart   +10 more
doaj   +1 more source

Relationship Between Helicobacter pylori IgG Seroprevalence and the Immune Response to Poliovirus Vaccine Among School-Age Children From a Population With Near-Universal Immunity Level

Frontiers in Medicine, 2022
ObjectivesTo examine the association between Helicobacter pylori seroprevalence and serum pepsinogens (PGs) as markers of gastric inflammation), with high neutralizing antibody titers to poliovirus type 1 and 3 vaccine strains among children age 3–4 ...
Layaly Badran Abu Zher, Merav Weil, Eias Kassem, Nael Elias, Myron M. Levine, Khitam Muhsen   +5 more
doaj   +1 more source

Poliovirus Vaccine

Uirusu, 2012
To avoid the risk of vaccine-associated paralytic poliomyelitis (VAPP) and polio outbreaks due to circulating vaccine-derived polioviruses, an inactivated poliovirus vaccine (IPV) was introduced for routine immunization in a number of countries with a low risk of polio outbreaks.
openaire   +3 more sources

Development of enterovirus 71 vaccines

, 2010
[[abstract]]Enterovirus 71 (EV71) was first isolated in 1969 in California, USA. Several epidemic outbreaks with high mortality rates have occurred in European and Asian Countries (Bulgaria in 1975, Hungary in 1978, Malaysia in 1997, Taiwan in 1998 and ...
Lee, MS;Chang, LY
core   +1 more source