Results 41 to 50 of about 218,086 (209)

Impact of polio vaccines (oral polio vaccine - OPV or inactivated polio vaccine - IPV) on rotavirus vaccine-associated intussusception

Human Vaccines & Immunotherapeutics, 2022
Although safe, rotavirus vaccines have been associated with increased intussusception risk. In Brazil, after the oral human rotavirus vaccine (OHRV) introduction in the childhood immunization, in 2006, increased intussusception risk was identified after ...
Camila Cristina Martini Rodrigues, Eder Gatti Fernandes, Paulo Piva dos Santos, Renato Yoshio Eguti, Antonio Carlos Pedroso-de-Lima, Gisela Tunes da Silva, Ana Marli Christovam Sartori   +6 more
doaj   +1 more source

Protease-Independent Production of Poliovirus Virus-like Particles in Pichia pastoris: Implications for Efficient Vaccine Development and Insights into Capsid Assembly

Microbiology Spectrum, 2023
The production of enterovirus virus-like particles (VLPs) that lack the viral genome have great potential as vaccines for a number of diseases, such as poliomyelitis and hand, foot, and mouth disease.
Lee Sherry, Jessica J. Swanson, Keith Grehan, Huijun Xu, Mai Uchida, Ian M. Jones, Nicola J. Stonehouse, David J. Rowlands   +7 more
doaj   +1 more source

Recombination in enteroviruses is a biphasic replicative process involving the generation of greater-than genome length 'imprecise' intermediates [PDF]

, 2014
Recombination in enteroviruses provides an evolutionary mechanism for acquiring extensive regions of novel sequence, is suggested to have a role in genotype diversity and is known to have been key to the emergence of novel neuropathogenic variants of ...
David J Evans, Woodman, Andrew, Andrew Woodman, Kym Lowry (222718), Jonathan Cook (3435386), Andrew Woodman (577477), Cook, Jonathan, Cook, Jonathan P., David J. Evans (208308), Lowry, Kym, David J. Evans, Evans, David J., Kym Lowry, Jonathan Cook   +13 more
core   +1 more source

Advances and challenges in poliomyelitis vaccines: a comprehensive review of development, production, and global deployment

Frontiers in Public Health
Poliomyelitis has been a significant global health challenge for centuries. Since the launch of the Global Polio Eradication Initiative (GPEI) in 1988, remarkable progress has been achieved, with wild poliovirus (WPV) cases reduced by over 99%.
Jia Liang, Qi Zhang, Yanan Li, Lili Wang
doaj   +1 more source

The effect of HIV-exposure on immune responses to expanded programme on immunization vaccines and antigens [PDF]

, 2013
Includes abstract.Includes bibliographical references.Immunization against vaccine-preventable infections is essential to reducing childhood morbidity and mortality.
Kidzeru, Elvis Banboye
core   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Ascertainment of childhood vaccination histories in northern Malawi.

, 2008
OBJECTIVE: To assess factors related to recorded vaccine uptake, which may confound the evaluation of vaccine impact. METHODS: Analysis of documented vaccination histories of children under 5 years and demographic and socio-economic characteristics ...
Mwinuka, V, Mwagomba, D., Crampin, A.C., McGrath, N, J. Mwafilaso, A. Jahn, Karsulukuta, A., Khunga, A, P. E. M. Fine, Mkisi, RE, Branson, K, A. Katsulukuta, Floyd, S., A. C. Crampin, K. Branson, V. Mwinuka, Branson, K., Fine, P.E.M., Mwafilaso, J., McGrath, N., D. Mwagomba, Khunga, A., S. Floyd, Katsulukuta, A, A. Khunga, Mwafilaso, J, N. McGrath, Jahn, A, Jahn, A., Mwinuka, V., R. E. Mkisi, Crampin, AC, Mwagomba, D, Mkisi, R.E., Katsulukuta, A., Fine, PEM, Floyd, S   +36 more
core   +1 more source

Development of Thermostable Lyophilized Sabin Inactivated Poliovirus Vaccine

mBio, 2018
As oral poliovirus vaccine (OPV) causes vaccine-associated paralytic poliomyelitis, the polio endgame strategy introduced by the Global Polio Eradication Initiative calls for a phased withdrawal of OPV and an introduction of inactivated poliovirus ...
Woo-Jin Shin, Daiki Hara, Francisca Gbormittah, Hana Chang, Byeong S. Chang, Jae U. Jung   +5 more
doaj   +1 more source

Purification and concentration of model viruses using single‐pass tangential flow filtration

Biotechnology Progress, EarlyView.
Single‐pass TFF was developed for an enveloped and non‐enveloped virus for use in continuous downstream purification processes. Enveloped virus was concentrated and purified. Abstract The vaccine and viral vector industry is growing at an accelerated rate.
Luis Alberto Mejía‐Manzano, Lynn Manchester, Grace Wallis, Kan Wang, Bruce P. Lee, Michael Betenbaugh, Caryn L. Heldt   +6 more
wiley   +1 more source

Health System Resilience and Afghan Refugee Health in Pakistan: An Exploratory Study of Challenges and Pathways to Inclusion

The International Journal of Health Planning and Management, EarlyView.
ABSTRACT Pakistan has hosted Afghan refugees for more than four decades, in one of the world's most protracted displacements of people. Afghan refugees receive health services through United Nations High Commissioner for Refugees (UNHCR) and non‐governmental organisation (NGO) supported programmes alongside public sector facilities at every tier.
Zahid Ali Memon, Asma Ummad, Amina Olabi, Natasha Palmer, Sophie Witter   +4 more
wiley   +1 more source