Results 101 to 110 of about 17,357,527 (148)

Polo-like kinase 4 is associated with advanced TNM stages and reduced survival and its inhibition improves chemosensitivity in colorectal cancer. [PDF]

Oncol Lett, 2022
Duan Z, Cai L, Cao J, Wu W.
europepmc   +1 more source

A Role for Polo-Like Kinase 4 in Vascular Fibroblast Cell-Type Transition. [PDF]

JACC Basic Transl Sci, 2021
Li J, Urabe G, Huang Y, Zhang M, Wang B, Marcho L, Shen H, Kent KC, Guo LW.   +8 more
europepmc   +1 more source

Polo-like kinase 3 is associated with poor prognosis and regulates proliferation and metastasis in prostate cancer

, 2019
Chunhao Lin,1,2,* Shoumin Bai,1,3,* Tao Du,4 Yiming Lai,2 Xianju Chen,5 Shengmeng Peng,2 Xiaoming Ma,2 Wanhua Wu,2 Zhenghui Guo,1,2 Hai Huang1,2 1Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial
Lai Y, Bai S, Lin C, Guo Z, Du T, Peng S, Huang H, Ma X, Chen X, Wu W   +9 more
core  

Purification and Cloning of a Protein Kinase That Phosphorylates and Activates the Polo-Like Kinase Plx1

, 1998
The Xenopus polo-like kinase 1 (Plx1) is essential during mitosis for the activation of Cdc25C, for spindle assembly, and for cyclin B degradation.
Eleanor Erikson, Yue-Wei Qian, James L. Maller   +2 more
core   +1 more source

Inhibiting Polo-like kinase 1 causes growth reduction and apoptosis in pediatric acute lymphoblastic leukemia cells

This study investigated Polo-like kinase 1, a mitotic regulator often over-expressed in solid tumors and adult hematopoietic malignancies, as a potential new target in the treatment of pediatric acute lymphoblastic leukemia.
Caron HN, Williamson D, Horstmann M, Allen M, Clifford SC, Exalto C, Hartsink-Segers SA, Pieters R, Den Boer ML   +8 more
core   +4 more sources

Polo-like Kinase 4: the Variation During Therapy and its Relation to Treatment Response and Prognostic Risk Stratification in Childhood Acute Lymphoblastic Leukemia Patients. [PDF]

J Pediatr Hematol Oncol, 2023
Xu J, Zhao L.
europepmc   +1 more source

Distinct pathophysiological mechanisms of CEP152 variants in microcephaly and brain abnormalities

EMBO Molecular Medicine
CEP152 is essential for centriole function and neurodevelopment, and pathogenic recessive variants in CEP152 cause primary microcephaly. We identified new compound heterozygous CEP152 variants, c.314 G > A,p.(W105*) and c.2689 A > T,p.(K897*), in a ...
Nanako Hamada, Lama AlAbdi, Tomoko Uehara, Looprasertkul Sasikarn, Takuma Nishijo, Reut Suliman-Lavie, Mais O Hashem, Majid Alfadhel, Shatha Alhefdhi, Brahim Tabarki, Malak Alghamdi, Ikuko Iwamoto, Toshiki Takenouchi, Kenjiro Kosaki, Sagiv Shifman, Seiji Mizuno, Nobuhiko Ohno, Fowzan S Alkuraya, Koh-ichi Nagata   +18 more
doaj   +1 more source

Tipping the balance: synthesis and evaluation of centrinone-based degraders of polo-like kinase 4. [PDF]

RSC Chem Biol
Kovacevic A, Salim A, Borges C, Meraldi P, Hoogendoorn S.   +4 more
europepmc   +2 more sources

Centrosome amplification and aneuploidy driven by the HIV-1-induced Vpr•VprBP•Plk4 complex in CD4+ T cells

Nature Communications
HIV-1 infection elevates the risk of developing various cancers, including T-cell lymphoma. Whether HIV-1-encoded proteins directly contribute to oncogenesis remains unknown.
Jung-Eun Park, Tae-Sung Kim, Yan Zeng, Melissa Mikolaj, Jong Il Ahn, Muhammad S. Alam, Christina M. Monnie, Victoria Shi, Ming Zhou, Tae-Wook Chun, Frank Maldarelli, Kedar Narayan, Jinwoo Ahn, Jonathan D. Ashwell, Klaus Strebel, Kyung S. Lee   +15 more
doaj   +1 more source

Exploring the potential mechanisms of sorafenib resistance in hepatocellular carcinoma cell lines based on RNA sequencing

Cancer Cell International
Background Exploring the mechanisms underlying sorafenib resistance that arises in hepatocellular carcinoma (HCC) may provide new treatment perspectives.
Minghui Sun, Zhi Zhang, Chunyan Chen, Juan Zhong, Zhongrong Long, Ling Shen, Hai Huang, Jianxun Lu   +7 more
doaj   +1 more source