Results 101 to 110 of about 15,343 (151)

Centrosome amplification and aneuploidy driven by the HIV-1-induced Vpr•VprBP•Plk4 complex in CD4+ T cells

Nature Communications
HIV-1 infection elevates the risk of developing various cancers, including T-cell lymphoma. Whether HIV-1-encoded proteins directly contribute to oncogenesis remains unknown.
Jung-Eun Park, Tae-Sung Kim, Yan Zeng, Melissa Mikolaj, Jong Il Ahn, Muhammad S. Alam, Christina M. Monnie, Victoria Shi, Ming Zhou, Tae-Wook Chun, Frank Maldarelli, Kedar Narayan, Jinwoo Ahn, Jonathan D. Ashwell, Klaus Strebel, Kyung S. Lee   +15 more
doaj   +1 more source

MicroRNA‑126 suppresses the proliferation and migration of endothelial cells in experimental diabetic retinopathy by targeting polo‑like kinase 4. [PDF]

Int J Mol Med, 2021
Zheng Y, Liu Y, Wang L, Xu H, Lu Z, Xuan Y, Meng W, Ye L, Fang D, Zhou Y, Ke K, Liu Y, An M.   +12 more
europepmc   +1 more source

Exploring the potential mechanisms of sorafenib resistance in hepatocellular carcinoma cell lines based on RNA sequencing

Cancer Cell International
Background Exploring the mechanisms underlying sorafenib resistance that arises in hepatocellular carcinoma (HCC) may provide new treatment perspectives.
Minghui Sun, Zhi Zhang, Chunyan Chen, Juan Zhong, Zhongrong Long, Ling Shen, Hai Huang, Jianxun Lu   +7 more
doaj   +1 more source

Role of Polo-Like Kinase 4 (PLK4) in Epithelial Cancers and Recent Progress in its Small Molecule Targeting for Cancer Management. [PDF]

Mol Cancer Ther, 2021
Garvey DR, Chhabra G, Ndiaye MA, Ahmad N.   +3 more
europepmc   +1 more source

Polo-like kinase 4 (PLK4; STK18) [PDF]

Science-Business eXchange, 2013
openaire   +1 more source

Fraxetin down-regulates polo-like kinase 4 (PLK4) to inhibit proliferation, migration and invasion of prostate cancer cells through the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway. [PDF]

Bioengineered, 2022
Ma Z, Sun Y, Peng W.
europepmc   +1 more source

Polo-like Kinase 4 Inhibitor CFI-400945 Fumarate [PDF]

, 2020
openaire   +1 more source

Inhibition of Aberrantly Overexpressed Polo-like Kinase 4 Is a Potential Effective Treatment for DNA Damage Repair-Deficient Uterine Leiomyosarcoma. [PDF]

Clin Cancer Res
Lee HHY, Chow KL, Wong HS, Chong TY, Wong AST, Cheng GHW, Ko JMK, Siu HC, Yeung MCF, Huen MSY, Tse KY, Bray MR, Mak TW, Leung SY, Ip PPC.   +14 more
europepmc   +1 more source

Polo-like kinase 4 and Stromal antigen 3 are not associated with recurrent pregnancy loss caused by embryonic aneuploidy. [PDF]

Hum Genome Var, 2020
Yoshihara H, Sugiura-Ogasawara M, Ozawa F, Kitaori T, Ozaki Y, Aoki K, Shibata Y, Ugawa S, Nishiyama T, Omae Y, Tokunaga K.   +10 more
europepmc   +1 more source

Use of the Polo-like kinase 4 (PLK4) inhibitor centrinone to investigate intracellular signalling networks using SILAC-based phosphoproteomics. [PDF]

Biochem J, 2020
Byrne DP, Clarke CJ, Brownridge PJ, Kalyuzhnyy A, Perkins S, Campbell A, Mason D, Jones AR, Eyers PA, Eyers CE.   +9 more
europepmc   +1 more source