Results 91 to 100 of about 17,357,527 (148)

Polo-like Kinase 4: A Multifaceted Marker Linking Tumor Aggressiveness and Unfavorable Prognosis, and Insights into Therapeutic Strategies. [PDF]

Cancers (Basel), 2023
Kim Y, Hwang JY, Kim DK, Na K, Lee S, Baek S, Kang SS, Yang SM, Kim MH, Han H, Lee CY, Han YJ, Hong MH, Lee JB, Lim SM, Cho BC, Park Y, Pyo KH.   +17 more
europepmc   +1 more source

The balance of Polo-like kinase 1 in tumorigenesis [PDF]

, 2009
Polo-like kinase 1 (Plk1) belongs to a family of conserved serine/threonine kinases with a polo-box domain, which have similar but non-overlapping functions in the cell cycle progression. Plk1 plays a key role to ensure the normal mitosis. Interestingly,
Yu, Xiaochun, Lu Lin-Yu, Yu Xiaochun, Lin-Yu Lu, Xiaochun Yu, Lu, Lin-Yu   +5 more
core   +1 more source

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation

Nature Communications
The Eyes Absent proteins (EYA1-4) are a biochemically unique group of tyrosine phosphatases known to be tumour-promoting across a range of cancer types. To date, the targets of EYA phosphatase activity remain largely uncharacterised.
Christopher B. Nelson, Samuel Rogers, Kaushik Roychoudhury, Yaw Sing Tan, Caroline J. Atkinson, Alexander P. Sobinoff, Christopher G. Tomlinson, Anton Hsu, Robert Lu, Eloise Dray, Michelle Haber, Jamie I. Fletcher, Anthony J. Cesare, Rashmi S. Hegde, Hilda A. Pickett   +14 more
doaj   +1 more source

Polo-like kinase 4 homodimerization and condensate formation regulate its own protein levels but are not required for centriole assembly. [PDF]

Mol Biol Cell, 2023
Ryniawec JM, Buster DW, Slevin LK, Boese CJ, Amoiroglou A, Dean SM, Slep KC, Rogers GC.   +7 more
europepmc   +1 more source

Activation of PBK by Gal-3 contributes to pulmonary artery hypertension by promoting PRC1 activation

Respiratory Research
Background Galactose lectin-3 (Gal-3) has been shown to promote the progression of pulmonary arterial hypertension (PAH), yet the intricate molecular mechanisms are still unclear.
Jia Zhang, Jin Liu, Yuqian Chen, Huan Chen, Yihan Meng, Yan Wang, Yuanjie Qiu, Huizhong Hu, Wenhua Shi, Manxiang Li   +9 more
doaj   +1 more source

MT-4 suppresses resistant ovarian cancer growth through targeting tubulin and HSP27.

PLoS ONE, 2015
ObjectiveIn this study, the anticancer mechanisms of MT-4 were examined in A2780 and multidrug-resistant NCI-ADR/res human ovarian cancer cell lines.MethodsTo evaluate the activity of MT-4, we performed in vitro cell viability and cell cycle assays and ...
Hui Chen Pai, Sunil Kumar, Chien-Chang Shen, Jing Ping Liou, Shiow Lin Pan, Che Ming Teng   +5 more
doaj   +1 more source

Balancing the scales: fine-tuning Polo-like kinase 4 to ensure proper centriole duplication. [PDF]

Genes Dev, 2022
Ryniawec JM, Rogers GC.
europepmc   +1 more source

Aberrant expression of polo-like kinase 4 in renal cell carcinoma: Association with clinicopathological characteristics and long-term survival. [PDF]

Oncol Lett, 2022
Jiang W, Zhao Y, Zhang S, Zeng Y, Ma J.
europepmc   +1 more source

Combined Delivery of Temozolomide and siPLK1 Using Targeted Nanoparticles to Enhance Temozolomide Sensitivity in Glioma

International Journal of Nanomedicine, 2020
Hui Shi,1,2,* Shuo Sun,1,* Haoyue Xu,3,* Zongren Zhao,3 Zhengzhong Han,3 Jun Jia,3 Dongmei Wu,4 Jun Lu,4 Hongmei Liu,3,5 Rutong Yu1,3,5 1Clinical Medical College, Nanjing Medical University, Nanjing, People’s Republic of China; 2The Second People ...
Shi H, Sun S, Xu H, Zhao Z, Han Z, Jia J, Wu D, Lu J, Liu H, Yu R   +9 more
doaj  

Targeting PLK1-CBX8-GPX4 axis overcomes BRAF/EGFR inhibitor resistance in BRAFV600E colorectal cancer via ferroptosis

Nature Communications
Metastatic BRAFV600E colorectal cancer (CRC) confers poor prognosis and represents a therapeutic bottleneck. To identify resistance mechanisms of the mitogen-activated protein kinase (MAPK) pathway in BRAFV600E CRC, we perform genome-wide CRISPR-Cas9 ...
Zhan Zhao, Jiashuai He, Shenghui Qiu, Lu Wang, Shuchen Huangfu, Yangzhi Hu, Qing Wu, Yabing Yang, Xiaobo Li, Maohua Huang, Shijin Liu, Hanyang Guan, Zuyang Chen, Xiangwei Zhang, Yiran Zhang, Hui Ding, Xiaoxu Zhao, Guandi Xiao, Yunlong Pan, Tongzheng Liu, Yanping Wu, Jinghua Pan   +21 more
doaj   +1 more source