Results 71 to 80 of about 17,357,527 (148)

Posttranslational Modifications of p62/SQSTM1 in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Schematic illustration of p62 as a posttranslational modifications (PTMs)‐programmed integrator in homeostasis, pathogenesis, and therapeutic targeting. (Left) Homeostasis: In physiological states, p62, through various PTMs such as phosphorylation, ubiquitination, and acetylation, coordinates essential cellular functions.
Weikai Wang, Xin Jiang, Runing Qiu, Chandra Sugiarto Wijaya, Miaoqin Chen, Jin Wang, Liyuan Zhu, Hongchuan Jin, Lifeng Feng   +8 more
wiley   +1 more source

Interdependency and phosphorylation of KIF4 and condensin I are essential for organization of chromosome scaffold. [PDF]

PLoS ONE, 2017
Kinesin family member 4 (KIF4) and condensins I and II are essential chromosomal proteins for chromosome organization by locating primarily to the chromosome scaffold.
Rawin Poonperm, Hideaki Takata, Susumu Uchiyama, Kiichi Fukui   +3 more
doaj   +1 more source

Oclacitinib for Controlling Pruritus and Associated Skin Lesions in 16 Horses With Allergic Dermatitis

Veterinary Dermatology, Volume 37, Issue 5, Page 672-680, October 2026.
Background: Oclacitinib is a Janus kinase inhibitor approved for the treatment of pruritus associated with allergic dermatitis in dogs and may be effective in horses. Objectives: To evaluate the efficacy of oclacitinib in reducing pruritus and skin lesions in horses with allergic dermatitis.
Maturawan Tunhikorn, Photchanun Maneephan, Natcha Tovanakasame, Chalidaporn Kampang, Pusprapa Jandee, Panpanga Sangsuriya, Nuttawut Nuchprayoon   +6 more
wiley   +1 more source

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, Volume 4, Issue 3, September 2026.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source

Organoids in Precision Radiotherapy: Methodological Foundations, Tumor‐Specific Evidence, and Translational Roadmaps

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Background Radiotherapy remains a cornerstone of cancer treatment, while its efficacy is often limited by tumor radioresistance and the risk of normal tissue toxicity. Conventional preclinical models, including two‐dimensional (2D) cell cultures and murine xenografts, exhibit significant limitations in recapitulating human tumor ...
Yixian Zhu, Yawei Jiao, Jiao Xue, Xiaoli Lv, Songbing Qin   +4 more
wiley   +1 more source

Marcadores moleculares e morfológicos da citocinese em Trypanosoma rangeli [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biotecnologia e Biociências, Florianópolis, 2013.O Trypanosoma rangeli é um protozoário que, embora estreitamente relacionado ao ...
Prestes, Elisa Beatriz
core  

Computational Design of Targeted Inhibitors of Polo-Like Kinase 1 (Plk1)

, 2012
Computational design of small molecule putative inhibitors of Polo-like kinase 1 (Plk1) is presented. Plk1, which regulates the cell cycle, is often over expressed in cancers. Down regulation of Plk1 has been shown to inhibit tumor progression.
Krupa S. Jani, D.S. Dalafave
core   +1 more source

Functional characterization of human NDR kinases : novel regulatory mechanisms and a path towards direct substrates [PDF]

, 2012
Protein kinases are important regulators of signal transduction pathways in both unicellular and multicellular organisms. They play critical roles in biological processes such as cell growth, division, differentiation, adhesion, motility and cell death ...
Kohler, Reto
core   +1 more source

Magnetic Nanomedicine for Cancer: Mechanisms, Modalities, and Translation

Nano Select, Volume 7, Issue 9, September 2026.
At the convergence of nanotechnology, precision oncology and intelligent therapeutics, magnetic nanoparticles (MNPs) are redefining how cancer is detected, targeted and treated. This review critically examines the mechanisms enabling their integration in imaging, targeted drug delivery and magnetic hyperthermia, while exploring how intelligent design ...
Shivani Kadam, Rahul M. Sonavale, Ratnesh Das, Jayant Pawar, Nutan Shukla, Zhengyou Li, Girish R. Pathade, Nishabh Kushwaha, Asha Patel, Sushilkumar A. Jadhav, Samuel B. Adeloju   +10 more
wiley   +1 more source

Investigating the cellular and molecular mechanisms involved in establishing and maintaining centrosome asymmetry in Drosophila neuroblasts [PDF]

, 2015
Centrosome asymmetry has been implicated in stem cell fate maintenance in both flies and vertebrates. Drosophila neuroblasts, the neural precursors of the fly’s central nervous system, contain molecularly and physically asymmetric centrosomes.
Nair, Anjana Ramdas
core   +1 more source